Clinical trials: Primary Parkinsonism
Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis
Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases
The etiology of many neurodegenerative diseases is unknown. A few studies have suggested the role of infection in the gastrointestinal tract in the etiology and pathogenesis of neurological diseases such as idiopathic Parkinson.
- Conditions
- Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT01954875
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Parkinson Disease
Emotional Prosody Treatment in Parkinson's
This study investigates a treatment protocol which holds the potential to significantly improve communication and quality of life for individuals affected by Parkinson's disease (PD).
- Trial name
- NCT01956266
- Testing
- Emotional prosodic treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Exploring the Relationship Between L-dopa Responsiveness and Small Intestinal Microbiome in Parkinson's Disease
The investigators hypothesize that small intestinal (SI) microbiome biomarkers predict the responsiveness to oral levodopa/carbidopa in people with Parkinson's disease (PwPD).
- Trial name
- LENSER (NCT06762028)
- Testing
- SIMBA capsule
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Parkinson Disease, PARK8, Parkinson Disease
Molecular Pathology and Neuronal Networks in LRRK2 Parkinson's Disease
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized clinically by bradykinesia, resting tremor, rigidity, and postural instability.
- Conditions
- Parkinson Disease, PARK8, Parkinson Disease, Idiopathic Parkinson Disease
- Trial name
- NCT03782753
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- King's College London
Parkinson s Disease
Primary Parkinsonian Pain: Clinical Association and Phenotype
Among the different types of pain observed in Parkinson's disease, primary parkinsonian pain (PPP) is the most severe, the most difficult to treat, but also the least well characterized and the hardest to describe, not only by…
- Trial name
- PHENOPAIN (NCT07702266)
- Testing
- Online self-administered questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acoustic Stimulation, Parkinson Disease
Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life.
- Conditions
- Acoustic Stimulation, Parkinson Disease, Electroencephalography
- Trial name
- NCT05782322
- Testing
- Upper-limb training involving RAS, Upper-limb training without the aid of RAS
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Parkinson's Disease, Off Episodes of Parkinson Disease
A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes
A cardiac safety study of an investigational drug to see how it affects the heart in people with Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes)
- Trial name
- NCT03187301
- Testing
- APL-130277, Moxifloxacin
- Where
- 15 sites in United States, Italy
- Volunteers
- 48 people
- Sponsor
- Sumitomo Pharma America, Inc.
Movement Disorders, Parkinson's Disease
A Study of Movement Disorders Using the QMAT At-Home Testing Device
Background: Parkinson s disease (PD) affects half a million Americans, causing slow movements, tremors, stiffness, and trouble walking.
- Trial name
- NCT01905839
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
Rock Steady Boxing vs. Sensory Attention Focused Exercise
This study evaluates the effect on Rock Steady Boxing (RSB) and PD SAFEx on Parkinson's disease.
- Trial name
- NCT03618901
- Testing
- Rock Steady Boxing, PD SAFEx
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Advanced Idiopathic Parkinson's Disease
A Phase 4, Open-label Study to Assess the Feasibility and Efficacy on Motor and Non-motor Symptoms of Switching From Pramipexole or Ropinirole to Rotigotine Transdermal Patch in Subjects With Advanced Idiopathic Parkinson's Disease
The purpose of this study is to assess the safety and feasibility of switching subjects with advanced Parkinson's Disease (PD) from Pramipexole or Ropinirole to Rotigotine and to assess the effects of Rotigotine on motor and…
- Trial name
- NCT01711866
- Testing
- Rotigotine
- Where
- 21 sites in United States, Malaysia and 3 more
- Volunteers
- 87 people
- Sponsor
- UCB BIOSCIENCES GmbH
Hyposmia, Parkinson Disease
The Vietnamese Smell Identification Test in the Diagnosis of Parkinson's Disease
The goal of this observational study is to assess the value of the Vietnamese smell identification test (VSIT) in the diagnosis of Parkinson's disease, and compare it with the commonly used test in the world, Brisk smell…
- Trial name
- NCT05837637
- Testing
- The Vietnamese Smell Identification test (VSIT), the Brief Smell Identification test (BSIT)
- Where
- Vietnam
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Parkinson's Disease Psychosis, Dementia With Lewy Bodies
Comparing Antipsychotic Medications in LBD Over Time
The primary objective of this study is to determine whether treatment with pimavanserin or quetiapine is associated with a greater improvement in psychosis when used in a routine clinical setting to treat hallucinations and/or…
- Trial name
- CAMELOT (NCT05590637)
- Testing
- Pimavanserin, Quetiapine
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Parkinson's Disease
Prospective Evaluation of Forceplate Measured Levodopa-Induced Dyskinesia
Nearly all Parkinson's disease (PD) patients eventually develop abnormal and unwanted movements (dyskinesias; LID) caused by the gold standard treatment, Levodopa.
- Trial name
- NCT00912977
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking.
- Trial name
- NCT06911229
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Parkinson's Disease
Development of a Face Valid Executive Functioning Task
The purpose of this study is to develop a task to measure executive thinking skills that can be performed in a laboratory setting, but has clear parallels to the thinking demands of real life situations, and can be administered…
- Trial name
- MedTask (NCT00918112)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson's Disease
Use and Misuse of Domperidone in Parkinson's Disease in France - Dump Investigation
Parkinson disease is the second most frequent neurodegenerative disease after Alzheimer disease and affect 1% of the population over 60 years. The treatment of PD is based on dopamine replacement therapies (DRT).
- Trial name
- DUMP-invest (NCT03837067)
- Where
- France
- Volunteers
- 2,300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson''s Disease
Pilot Study of Safety and Efficacy of Spheramine
Tolerability and Efficacy of Spheramine will be evaluated after operative implantation (Stereotactic Intrastriatal Implantation) in patients with advanced Parkinson's Disease
- Trial name
- NCT00761436
- Testing
- Spheramine (BAY86-5280)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Bayer
Parkinson Disease, Parkinson's Disease
An Open-label Continuation Study Evaluating the Long-term Safety of Extended Release Ropinirole XL (Formerly CR) in Parkinson''s Disease
To evaluate the safety profile of ropinirole XL during long-term treatment in subjects with early and advanced Parkinson's disease
- Trial name
- NCT00632736
- Testing
- Ropinirole XL (formerly CR)
- Where
- 75 sites in United States, Belgium and 7 more
- Volunteers
- 419 people
- Sponsor
- GlaxoSmithKline
Parkinson Disease
Clinical Trial for Parkinson's Disease Using Allogeneic HB-adMSCs (Early and Moderate PD)
This is a randomized, double-blind, single center, phase 2 study to assess efficacy and safety of multiple allogeneic HB-adMSCs vs Placebo for the treatment of Parkinson's disease.
- Trial name
- NCT04995081
- Testing
- Biological/Vaccine: Allogeneic HB-adMSCs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hope Biosciences Research Foundation
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
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