Clinical trials: Primary Prevention of Cardiovascular Disease
Moderate Risk of CVD
A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease
The use of acetylsalicylic acid in the primary prevention of cardiovascular events has been extensively studied but to a lesser extent in patients with moderate levels of cardiovascular risk.
- Trial name
- ARRIVE (NCT00501059)
- Testing
- Aspirin (Acetylsalicylic acid, BAYE4465)
- Where
- 466 sites in United States, Germany and 6 more
- Volunteers
- 12,546 people
- Sponsor
- Bayer
Cardiomyopathies
Assessment of Appropriate ICD Implantation for Primary Prevention of Sudden Cardiac Death
Prophylactic implant of an ICD (implantable cardioverter defibrillator) for prevention of sudden cardiac death from a life-threatening heart rhythm abnormality is a standard recommendation for patients with ejection fractions…
- Trial name
- NCT00926159
- Volunteers
- 549 people
- Sponsor
- University of Minnesota Physicians Heart at Fairview
Atherosclerotic Cardiovascular Disease, Cardiovascular Disease
Intima-Medial Thickness Guidance of Primary Prevention in Relatives of Patients With Early onSet Atherosclerosis
The primary objective of this study is, to instigate a reduction in atherosclerotic burden within the carotid arteries in the intervention group compared to the control group and to demonstrate parallel improvements in…
- Trial name
- IMPRESS (NCT01330602)
- Testing
- IMPRESS intervention
- Where
- 3 sites in Singapore
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Cardiovascular Diseases
Pharmaco-metabolomic Effects of Statins: METASTATINE
Statins are effective in cardio-vascular prevention by lowering LDL-Cholesterol levels but also through other mechanisms poorly understood.
- Trial name
- METASTATINE (NCT03837925)
- Testing
- Atorvastatin 40mg Tablet
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- French Cardiology Society
Stroke
Hydroxyurea to Prevent Stroke in Children With Sickle Cell Anemia and Elevated TCD Flow Velocity
The purpose of this study is to assess prospectively the efficacy of hydroxyurea therapy in the setting of cerebrovascular disease, manifest as conditional or abnormal transcranial doppler ultrasonography (TCD) flow velocities…
- Trial name
- NCT00402480
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University