Clinical trials: Primary Prevention of Cardiovascular Disease
Angioedema
Study of Heparin Prophylaxis of Hereditary Angioedema Exacerbations
OBJECTIVES: I. Determine the safety and efficacy of inhaled and subcutaneously administered heparin in the treatment of hereditary angioedema.
- Trial name
- NCT00004694
- Testing
- heparin
- Volunteers
- 24 people
- Sponsor
- University of Iowa
Cardiovascular Diseases
The Indian POLYCAP Study (TIPS)
STUDY TITLE A randomized double-blind controlled trial of the efficacy and safety of the POLYCAP® versus its components in subjects aged 45 to 80 years of age with at least one additional cardiovascular risk factor.
- Trial name
- NCT00443794
- Testing
- Thiazides, Ramipril with Thiazide, Thiazide plus atenolol
- Where
- 54 sites in India
- Volunteers
- 2,050 people
- Sponsor
- St. John's Research Institute
Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection
Lung Cancer Prevention Screening Programme in Italy
This prospective randomized multicentered clinical study aims at implementing early diagnosis of lung cancer in high-risk heavy smokers in the Italian population.
- Conditions
- Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection, Cardiovascular Diseases
- Trial name
- RISP (NCT05766046)
- Testing
- early lung cancer detection, blood test
- Where
- Italy
- Volunteers
- 7,324 people, healthy volunteers welcome
- Sponsor
- Ugo Pastorino
Cardiovascular (CV) Risk, Metabolic Health
Advancing Health Equity and Preventive Cardiovascular Care in Indigenous and Remote Communities: a Mobile Healthcare Unit
Indigenous people living in Canada face significant healthcare inequities, particularly in basic, primary, and secondary prevention, leading to higher rates of cardiovascular disease and mortality.
- Conditions
- Cardiovascular (CV) Risk, Metabolic Health, Primary Prevention
- Trial name
- NCT07869069
- Testing
- Cardiovascular risk screening, Follow-up of cardiovascular risk factors
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypertension, Diabetes
mWELLCARE:An Integrated mHealth System for the Prevention and Care of Chronic Disease
Major barriers to controlling cardiovascular diseases (CVDs) in India and elsewhere are: low detection rates, inadequate use of evidence based interventions and low adherence with these interventions.
- Conditions
- Hypertension, Diabetes, Depression, Alcohol Use Disorder
- Trial name
- mWELLCARE (NCT02480062)
- Testing
- mWELLCARE, Usual Care
- Where
- 40 sites in India
- Volunteers
- 3,702 people
- Sponsor
- Public Health Foundation of India
PRS-based Primary Prevention of CVD
Polygenic Risk Driven Pragmatic Statin Trial for Heart Disease Prevention
This research investigates the potential advantages of intensive preventive statin treatment for healthy men aged 45-80 and women aged 55-80 who possess a high genetic predisposition to coronary artery disease (CAD).
- Trial name
- EE-PRS (NCT06820086)
- Testing
- Rosuvastatin 20mg
- Where
- 2 sites in Estonia
- Volunteers
- 2,714 people
- Sponsor
- Mikk JÜRISSON
Cardiovascular Diseases, Overweight
Enhancing Mental and Physical Health of Women Veterans 3.0
Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that…
- Conditions
- Cardiovascular Diseases, Overweight, Obesity, Hypertension
- Trial name
- EMPOWER (NCT07356479)
- Testing
- EBQI Booster (EBQI/B), EBQI Booster + External Facilitation (EBQI/B+EF)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Myocardial Ischemia, Coronary Disease
Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury
The purpose of the study is to evaluate whether FX06 is capable of limiting infarct size following balloon catheterization for acute myocardial infarction.
- Conditions
- Myocardial Ischemia, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00326976
- Testing
- FX06, Percutaneous coronary intervention
- Where
- 32 sites in Austria, Belgium and 9 more
- Volunteers
- 234 people
- Sponsor
- Fibrex Medical Research & Development GmbH
Sickle Cell Disease, Stroke
Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II
The overall goal of this proposal is to conduct a partial double-blind randomized Phase III clinical trial for primary stroke prevention in children with sickle cell anemia (SCA) in sub-Saharan Africa.
- Trial name
- SPRING (NCT02560935)
- Testing
- Hydroxyurea (Moderate Dose), Hydroxyurea (Low Dose)
- Where
- 3 sites in Nigeria
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Anti-platelet Therapy in the Prevention of Cardiovascular Disease in Patients With COPD (APPLE-COPD: ICON 2)
Patients with COPD (chronic bronchitis and/or emphysema) are known to be at an increased risk of heart disease and death due to heart attacks.
- Trial name
- NCT03487406
- Testing
- Ticagrelor, Aspirin
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Cardiovascular Disease, Stroke
Effects of Message Framing and Time Discounting on Health Communication for Optimum Cardiovascular Disease and Stroke Prevention
Effects of Message framing and Time discounting on heath communication for Optimum Cardiovascular disease and Stroke Prevention（EMT-OCSP）is a pragmatic, 2 × 2 factorial, randomized, controlled, observer blinded, multicenter trial…
- Conditions
- Cardiovascular Disease, Stroke, Primary Prevention
- Trial name
- EMT-OCSP (NCT04450888)
- Testing
- The strategic use of messages in risk communication
- Where
- China
- Volunteers
- 13,114 people
- Sponsor
- West China Hospital
Obesity, Sedentary Lifestyle
The Healthy Options Feasibility Study
The investigators hypothesize that having health care providers other than physicians within a "Groupe de Médecine de Famille" conduct cardiovascular risk assessments and teach lifestyle interventions to primary prevention…
- Conditions
- Obesity, Sedentary Lifestyle, Dyslipidemia, Hypertension
- Trial name
- NCT00746460
- Testing
- CVD risk profile
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University
Medication Adherence
A BCT Intervention for Medication Adherence Among Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among participants on primary prevention statin…
- Trial name
- NCT05273736
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cardiovascular Diseases, Type 2 Diabetes
Health Dialogue Intervention Versus Opportunistic Screening for Type 2 Diabetes and Cardiovascular Disease Prevention
Chronic diseases such as cardiovascular disease and diabetes type 2 are major causes of death worldwide. Preventive interventions can be delivered through primary care, as this is the first-line healthcare with which a…
- Trial name
- NCT06067178
- Testing
- Health Dialogue Intervention, Opportunistic Screening
- Where
- Sweden
- Volunteers
- 1,206 people
- Sponsor
- Region Stockholm
Hereditary Angioedema (HAE)
Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks
The primary objectives of the study are to evaluate the safety, tolerability, and efficacy of two doses of CINRYZE with recombinant human hyaluronidase (rHuPH20) administered by subcutaneous (SC) injection to prevent angioedema…
- Trial name
- NCT01756157
- Testing
- CINRYZE with rHuPH20
- Where
- 23 sites in United States, Germany and 2 more
- Volunteers
- 47 people
- Sponsor
- Shire
ST Segment Elevation Myocardial Infarction (STEMI), No Reflow Phenomenon
The Investigator Administers Intracoronary Adrenaline Via the Catheter in STEMI Patients During Primary PCI, After Flow Restoration and Before Stenting, and Studies Its Effect in Prevention of No Reflow
The aim of this work is to study the role of intracoronary adrenaline administration as a preventive tool for no reflow in patients undergoing primary PCI.
- Trial name
- NCT06847568
- Testing
- Adrenaline
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- Ain Shams University
Cardiovascular Disease
Simplified Cardiovascular Management Study
The goal of this study is to develop, pilot test, and evaluate a highly simplified but guideline-based program for cardiovascular management for application in resource-scarce settings.
- Trial name
- SimCard (NCT01503814)
- Testing
- Simplified cardiovascular disease management
- Where
- 3 sites in China, India
- Volunteers
- 2,086 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Primary Prevention of Cardiovascular Diseases
Peer-led Digital Health Lifestyle Intervention for a Low Income Community at Risk for Cardiovascular Diseases (MYCardio-PEER)
The goal of this interventional study is to develop and assess the effectiveness of a peer-led digital health program (MYCardio-PEER) for primary prevention of cardiovascular disease (CVD) in a low-income community at-risk of…
- Trial name
- NCT06408493
- Testing
- MYCardio-PEER
- Where
- Malaysia
- Volunteers
- 63 people
- Sponsor
- Monash University Malaysia
Coronary Disease, Cardiovascular Diseases
Evaluating a Web-Based Educational Program for Adults at Risk for Coronary Heart Disease (The Heart to Heart Feasibility Study)
Coronary heart disease (CHD) is the leading cause of death in the United States, but fewer than half of all individuals at risk for CHD take advantage of proven strategies to lower their chances of developing this disease.
- Trial name
- NCT00494052
- Testing
- Heart to Heart (Web-Based Decision Aid), Physician Education Session
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Stroke
Hydroxyurea to Prevent Stroke in Children With Sickle Cell Anemia and Elevated TCD Flow Velocity
The purpose of this study is to assess prospectively the efficacy of hydroxyurea therapy in the setting of cerebrovascular disease, manifest as conditional or abnormal transcranial doppler ultrasonography (TCD) flow velocities…
- Trial name
- NCT00402480
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University