Clinical trials: Primary Total Knee Arthroplasty
Knee Osteoarthritis (Knee OA), Total Knee Anthroplasty
Drain Removal Before Versus After CPM in Primary Total Knee Arthroplasty
The aim of this prospective randomized controlled study was to determine whether the timing of drain removal in relation to continuous passive motion (CPM) application influences postoperative residual hematoma formation…
- Conditions
- Knee Osteoarthritis (Knee OA), Total Knee Anthroplasty, Postoperative Hematoma
- Trial name
- NCT07302724
- Testing
- Drain Removal Before CPM, Drain Removal After CPM
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Ankara Etlik City Hospital
Total Knee Arthroplasty
Personalized Information Before and After Total Knee Arthroplasty: PAK-study
Despite positive results following total knee arthroplasty (TKA), some patients are dissatisfied after recovery. Unfulfilled expectations is a key predictor of dissatisfaction.
- Trial name
- PAK (NCT05266482)
- Testing
- Personal report
- Where
- Netherlands
- Volunteers
- 461 people
- Sponsor
- Kliniek ViaSana
Knee Arthroplasty, Total
The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)
This is a perspective, randomized, blinded study with a parallel design and an allocation ratio of 1 to 1 for the treatment groups to assess the analgesic efficacy of adding the iPACK (injection between the popliteal artery and…
- Trial name
- NCT03703206
- Testing
- ultrasound guided injection of local anesthetic between the popliteal artery and the capsule of the knee (iPACK)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Osteoarthritis, Total Knee Replacement
Static and Dynamic Balance in Correlation With Quality of Life, in Primary Total Knee Replacement
Knee osteoarthritis (OA) is one of the most prevalent musculoskeletal complaints worldwide, affecting 30-40% of the population by the age of 65 yr.Individuals with knee OA suffer progressive loss of function.Balance is an…
- Trial name
- NCT00256958
- Testing
- total knee replacement
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Joint Diseases, Joint Pain
Subsartorial Nerve Block and Femoral Nerve Block in Total Knee Arthroplasty
The goal of this clinical trial is to compare two different types of nerve blocks in patients undergoing surgery for primary Total Knee Arthroplasty.
- Trial name
- NCT06074744
- Testing
- SSNB + IPACK, FNB + IPACK
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- Luzerner Kantonsspital
Arthropathy of Knee Joint
Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (the knee joint) is more effective at obtaining adequate tissue levels of the antibiotic than…
- Trial name
- NCT03506347
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee, Osteoarthritis, Hip
Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty
The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of Hip
- Trial name
- NCT05972603
- Testing
- 1.0 g Vancomycin powder into the wound, 0,35% povidone-iodine solution lavage
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Independent Public Healthcare Center in Rypin
Thromboembolism
A Cohort Study With 100 Subjects Having a Primary Total Knee Replacement, Taking Pradax Post Discharge for Ten Days
Currently standard of care for preventing blood clots in total knee replacement patients is the drug Fragmin which is a daily injection for 10 days after surgery.
- Trial name
- NCT00868179
- Testing
- Pradax
- Where
- Canada
- Sponsor
- Ross Leighton
Knee Osteoarthritis, Hip Osteoarthritis
Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
This research is being done to see if there is a difference between two different spinal anesthetics (Mepivacaine vs. Bupivacaine) as it relates to reducing post-operative complications and the time it takes for subjects to…
- Trial name
- NCT03838874
- Testing
- Low-Dose Bupivacaine, Mepivacaine
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Mayo Clinic
Total Knee Arthroplasty
Analysis of Patient Outcome Questionnaire Following Primary Knee Replacement
The intention is to explore whether there are factors which help us to understand why some patient outcomes are not successful and identify prediction factors for progression.
- Trial name
- NCT03132077
- Testing
- total knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 1,301 people
- Sponsor
- University of Salford
Sleep Quality Post-TKA, Postoperative Knee Function
Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty
Many patients experience poor sleep during recovery after total knee arthroplasty (TKA). Disturbed sleep can last weeks to months and may worsen pain, slow healing, and reduce overall quality of life.
- Conditions
- Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
- Trial name
- NCT07598734
- Testing
- Doxepin 6 mg, Ramelteon 8 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Washington
Acute Pain, Regional Anesthesia Morbidity
Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty
The study is a prospective randomized controlled trial comparing local infiltration of analgesia in the knee joint and adductor canal catheters for postoperative analgesia following a primary Total Knee Arthroplasty (TKA).
- Trial name
- NCT02603900
- Testing
- ropivacaine, bupivacaine, Adductor Canal Catheter
- Where
- United States
- Sponsor
- Thomas Jefferson University
Knee Osteoarthritis, Multimorbidity
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This prospective observational cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis.
- Trial name
- NCT07882316
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Balikesir Ataturk City Hospital
Total Knee Arthroplasty
Clinical and Functional Outcomes of Tourniquet Use in Primary Total Knee Arthroplasty
Many surgeons choose to perform total knee arthroplasty (TKA) surgery with the aid of a tourniquet. A tourniquet is a device that fits around the leg and restricts blood flow to the limb.
- Trial name
- NCT05581563
- Testing
- total knee arthroplasty(TKA)
- Volunteers
- 100 people
- Sponsor
- Mongi Slim Hospital
Osteoarthritis, Knee, Total Knee Arthroplasty
Oral Fluid vs IV Fluid After Primary TKA
The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Oral Fluid Replacement
- Trial name
- NCT06288815
- Testing
- Oral fluid, IV fluid
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Thammasat University Hospital
Hip-surgery, Knee-surgery
Prospective, Randomized Study of 2 Different Wound Dressings
The primary objective of this investigation is to evaluate the performance of a self-adhesive absorbent post-operative dressing coated with a soft silicone layer in minimize the risk of the development of blistering in subjects…
- Conditions
- Hip-surgery, Knee-surgery, Spinal-surgery
- Trial name
- Close (NCT01988818)
- Testing
- Mepilex® Border Post-Op, standard wound dressing
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Cologne
Knee Osteoarthritis
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee…
- Trial name
- NCT02863120
- Testing
- liposomal bupivacaine, bupivacaine HCl, Ropivacaine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Texas Orthopaedics, Sports and Rehabilitation Associates
Osteo Arthritis Knee
Post-op Ketamine Study
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption.
- Trial name
- NCT03865550
- Testing
- Isotonic saline, Ketamine Injectable Solution
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Contracture
Reducing Recurrent Knee Flexion Contracture by Correcting Leg Length Discrepancy After Total Knee Arthroplasty for OA
Moving one's joints through their full range of motion (ROM) is crucial for health and wellbeing. Those who are unable to do so have difficulty carrying out simple activities like walking or feeding themselves.
- Trial name
- NCT02861521
- Testing
- Shoe lift
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Ottawa Hospital Research Institute
Arthroplasties, Hip Replacement, Arthroplasties, Knee Replacement
Self-adherent Absorbent Silver Dressing in Adults After Hip or Knee Arthroplasty
The overall rationale for this investigation is to evaluate the clinical performance potential for Mepilex Border Post-Op Ag in the ability to minimize the risk of skin related post-operative wound complications such as…
- Trial name
- NCT03016078
- Testing
- Mepilex Border Post-Op Ag
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Molnlycke Health Care AB