Clinical trials: Priming
HER2-positive Breast Cancer, Male Breast Cancer
Ex Vivo-Expanded HER2-Specific T Cells and Cyclophosphamide After Vaccine Therapy in Treating Patients With HER2-Positive Stage IV Breast Cancer
RATIONALE : Laboratory-treated T cells may stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor…
- Conditions
- HER2-positive Breast Cancer, Male Breast Cancer, Stage IV Breast Cancer
- Trial name
- NCT01219907
- Testing
- HER-2/neu peptide vaccine, cyclophosphamide, ex vivo-expanded HER2-specific T cells
- Where
- United States
- Sponsor
- University of Washington
Dengue Virus
Comparison of Tetravalent Dengue Virus Purified Inactivated Vaccine and Tetravalent Dengue Virus Live Attenuated Vaccine
This study is a Phase 1, randomized, open-label study of the prime-boost vaccine candidates given in the prime-boost regimen previously demonstrated to have a high level of immunogenicity and immune durability: Day 0 prime (PIV)…
- Trial name
- NCT03141138
- Testing
- TDENV-PIV, TDENV-LAV F17
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Non-Small Cell Lung Cancer Stage, Chemoradiation
Pre Radiotherapy Daily Exercise Training in Non-Small Cell Lung Cancer
The aim of this study is to evaluate the feasibility and the effect of daily, individual, supervised and structured exercise training before radiotherapy in patients diagnosed with Non-Small Cell Lung Cancer.
- Trial name
- PRIME (NCT03066271)
- Testing
- Exercise +, Control +
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertension in Dialysis Patients, Fluid Overload in Dialysis Patients
Prepared Meals to Prime and Perpetuate Reduced Dietary Sodium Intake in Hemodialysis
This is a randomized clinical trial in which maintenance hemodialysis patients will be provided with salt restricted 'dialysis friendly' meals and compared to a control arm receiving usual care.
- Trial name
- PEPPERDISH (NCT03990311)
- Testing
- Sodium Restricted Meals, Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Tufts Medical Center
Ebola Virus Disease, Hemorrhagic Fever
Phase 1 Trial of Ebola Vaccine in Mali
Ebola virus causes an infection known as Ebola virus disease (EVD). This is generally a severe disease which can also lead to death. The 2014 outbreak of EVD in West Africa is the largest ever.
- Trial name
- NCT02267109
- Testing
- Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO Z
- Where
- Mali
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Metabolic Syndrome, Anxiety
PRebiotic Intervention for Metabolic and MEntal Health (PRIME)
The purpose of the study is to determine whether a daily prebiotic fibre blend can reduce systemic inflammation, dyslipidemia, and self-report measures of mental health in individuals with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Anxiety, Mood, Stress
- Trial name
- PRIME (NCT06216626)
- Testing
- myota's prebiotic fibre blend
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Myota GmbH
Healthy Young Adult, Neurophysiology
Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- KME-TBS (NCT06799260)
- Testing
- Ketone Monoester (KME), iTBS, cTBS
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
COVID-19, Maternal Vaccine Exposure
Priming of the NEonatal Immune System by Transfer of Maternal Immunity
Newborn babies and infants are susceptible to infections as their immune system is still immature. Maternal immune factors for example antibodies and immune cells mitigate this vulnerability.
- Conditions
- COVID-19, Maternal Vaccine Exposure, Respiratory Infections in Children
- Trial name
- NEST (NCT05429047)
- Testing
- Tozinameran, COVID-19, No SARS-CoV-2 exposure
- Where
- Germany
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Safety, Immunogenicity
EMaBS TB Vaccine Study
The study will commence with a dose-escalation and age de-escalation study in healthy adults and adolescents from the previous Entebbe Mother and Baby Study (EMaBS) in Entebbe, Uganda, focusing on ChAdOx1 85A, to provide safety…
- Trial name
- NCT03681860
- Testing
- ChAdOx185A, MVA85A, BCG
- Where
- 2 sites in Uganda, United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
ST Elevation Myocardial Infarction
MGuard™ Prime Stent System Clinical Trial in Patients With Acute ST Elevation Myocardial Infarction
To evaluate the safety and efficacy of the MGuard™ Prime stent in the treatment of blocked arteries in coronary arteries in patients undergoing a stenting procedure due to having a heart attack.
- Trial name
- MASTER-II (NCT01869738)
- Testing
- MGuard Prime, (BMS/DES)
- Where
- 56 sites in United States, Belgium and 10 more
- Volunteers
- 310 people
- Sponsor
- InspireMD
Unspecified Adult Solid Tumor, Protocol Specific
Topotecan Plus Sargramostim in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow…
- Trial name
- NCT00002950
- Testing
- sargramostim, topotecan hydrochloride
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Healthy
A Study to Evaluate Safety, Tolerability, and Immunogenicity of Heterologous Prime-boost Regimens Using the Multivalent Filovirus Vaccines Ad26.Filo and MVA-BN-Filo Administered in Different Sequences and Schedules in Healthy Adults
The purpose of this study is to test the safety and immunogenicity of MVA-BN-Filo and Ad26.Filo as heterologous prime-boost vaccine regimens in healthy adult participants.
- Trial name
- NCT02860650
- Testing
- Ad26.Filo, MVA-BN-Filo, Ad26.ZEBOV
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Influenza, Vaccine
Safety and Immunogenicity of a Live-attenuated Universal Flu Vaccine Followed by an Inactivated Universal Flu Vaccine
The clinical study will evaluate safety and the immune response of a prime- boost regimen with a live attenuated influenza vaccine (LAIV) prime and an inactivated split influenza vaccine (IIV) boost with or without adjuvant.
- Trial name
- NCT03300050
- Testing
- cH8/1N1 LAIV, AS03-adjuvanted cH5/1N1 IIV, cH5/1N1 IIV
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults
This is a single centre, randomized, placebo-controlled phase 1/2 study comparing two malaria vaccine candidates. The first vaccine candidate PfSPZ-CVac (Plasmodium falciparum sporozoites (PfSPZ) challenge administered with a…
- Trial name
- NCT05441410
- Testing
- Pyronaridine Tetraphosphate, Artesunate Drug Combination, PfSPZ Challenge (NF54), MVA ME-TRAP
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Sterility
Endometrial Priming for Embryo Transfer
The aim of this trial is compare two different endometrial priming protocols women that receive oral estrogens women that receive transdermal estrogens
- Trial name
- NCT01430650
- Testing
- Oral strogen, Transdermal strogen
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Parc de Salut Mar
Malaria
Clinical Trial for Malaria Vaccines to Test for Safety, Immune Response and Protection Against Malaria
The purpose of this study is to test the safety and effectiveness of a new malaria vaccine, the DNA-Ad vaccine. The study is specifically looking at a vaccine regimen against Plasmodium falciparum, the most deadly form of malaria.
- Trial name
- DNA-Ad (NCT00870987)
- Testing
- DNA vaccine prime, adenovirus type 5 vaccine boost
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Safety Issues
Safety and Tolerability Trial (MVA-BN-Brachyury/FPV-Brachyury)
An open-label Phase 1 trial to evaluate the safety and tolerability of MVA-BN-Brachyury priming and FPV-Brachyury boost vaccines modified to express brachyury and T-cell costimulatory molecules in patients with a metastatic or…
- Trial name
- NCT03349983
- Testing
- MVA-BN-Brachyury/ FPV-Brachyury
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Bavarian Nordic
Neuroendocrine Tumor of Pancreas, Multiple Endocrine Neoplasia Type 1
Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients
Patients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET).
- Trial name
- PRIME (NCT05037461)
- Testing
- High-dose-high precision MR-guided radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- J.M. de Laat
Rapid Sequence Induction, Rapid Sequence Intubation
Rapid Sequence Intubation With Rocuronium in Elderly Patients
With the prolongation of life expectancy, the frequency of surgical intervention and anesthesia increases in elderly patients. The rapid Sequence Intubation(RSI) technique is preferred in patients with aspiration risk and who…
- Conditions
- Rapid Sequence Induction, Rapid Sequence Intubation, Rocuronium
- Trial name
- NCT05067829
- Testing
- Train of four(TOF)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Disease
Coronary CT Angiography as the Primary Initial Method of Evaluating Patients With Subacute Chest Pain (CT PRIME)
This study is designed to evaluate a new approach to the diagnosis of chronic or sub-acute chest pain patients in the out-patient setting.
- Trial name
- CTPRIME (NCT00584337)
- Where
- United States
- Sponsor
- Corewell Health East