Clinical trials: Priming
Rectal Cancer, Rectal Adenocarcinoma
A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer
PRIME-RT is an open label, multi-centre phase II randomised trial with 1:1 allocation between arm A and arm B. The principal research question is whether the addition of durvalumab to FOLFOX chemotherapy and radiation treatment…
- Conditions
- Rectal Cancer, Rectal Adenocarcinoma, Rectal Neoplasms
- Trial name
- PRIME-RT (NCT04621370)
- Testing
- Durvalumab, FOLFOX, Short Course Radiotherapy (Arm A)
- Volunteers
- 48 people
- Sponsor
- Liz-Anne Lewsley
Readmission, mHealth
Mhealth and Teach-Back Effectiveness In 30-Day Readmissions Reduction
The Study is a feasibility randomized controlled trial aiming to assess the feasibility of mHealth (voice call and SMS) and teach-back interventions on reducing the 30 days readmission rate in the patients enrolled in the Sehat…
- Conditions
- Readmission, mHealth, Teach-Back Communication
- Trial name
- NCT04738669
- Testing
- mHealth, Teach-back
- Where
- Pakistan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Health Services Academy, Islamabad, Pakistan
Workplace Wellbeing
Primed to Thrive: Investigating the Combined Impact of Mindfulness Education and Meditation Practice on Psychological and Workplace Outcomes
Employees commonly experience stress and reduced well-being that can affect workplace functioning. This interventional study will evaluate whether combining mindfulness-related educational materials with a brief daily guided…
- Trial name
- BEGIN III (NCT07534683)
- Testing
- Meditation, Mindful Educational Material
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Stroke, Stroke Rehabilitation
Optimization of Time Parameters of Priming iTBS for Poststroke Motor Rehabilitation
The goal of this clinical trial is to identify the effect of different time intervals between continuous theta burst stimulation (cTBS) and intermittent theta burst stimulation(iTBS), on top of a standard robot-assisted training…
- Trial name
- TMS (NCT06612437)
- Testing
- continuous theta burst stimulation (cTBS), intermittent theta burst stimulation (iTBS), Robot-assisted training
- Where
- 2 sites in Hong Kong
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Covid19
Clinical Trial of the Immunogenicity, Safety, and Efficacy of the Gam-COVID-Vac Vaccine Against COVID-19 in Venezuela
Randomized, double-blind, placebo controlled clinical trial of immunogenicity, safety and efficacy of the Gam-COVID-Vac combined vector vaccine against the SARS-CoV-2-induced coronavirus infection in adults.
- Trial name
- VENEZUELA (NCT04642339)
- Testing
- Gam-COVID-Vac
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
To Determine Safety, Tolerability and Efficacy of ONCOS-102 in Combination With Chemotherapy
A Randomised Phase II Open-label Study With a Phase Ib Safety lead-in Cohort of ONCOS-102, an Immune-priming GM-CSF Coding Oncolytic Adenovirus, and Pemetrexed/Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma
The trial is an open-label, parallel group, multicentre trial that will recruit a total of 30 patients with malignant pleural mesothelioma.
- Trial name
- NCT02879669
- Testing
- ONCOS-102, Pemetrexed/cisplatin (carboplatin), Cyclophosphamide
- Where
- 7 sites in France, Spain
- Volunteers
- 31 people
- Sponsor
- Targovax Oy
People Living With HIV, Antibody Response
RENEW-SHCS: Safety and Immunogenicity of a Recombinant HIV Env Protein Vaccine in ARV-treated Adults Living With HIV in the SHCS
A vaccine trial in which people with HIV-1 participating in the Swiss HIV Cohort Study will receive a HIV-specific vaccine to stimulate antibodies against HIV while continuing their standard antiretroviral therapy
- Trial name
- RENEW-SHCS (NCT07769983)
- Testing
- The Patients will all receive a vaccination with a recombinant HIV-1 envelope protein BG505 SOSIP.GT1.1 gp140 vaccine, adjuvanted,.
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Patients With Cancer, Vaccine Reaction
Safety and Immunogenicity of Prime-boost Vaccination of SARS-CoV-2 in Patients With Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a global pandemic since late 2019 that resulted in more than 360 million population infection.
- Conditions
- Patients With Cancer, Vaccine Reaction, COVID-19
- Trial name
- NCT05273541
- Testing
- Coronavirus vaccination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing 302 Hospital
Infections, Meningococcal
Study to Asses DTPw-HBV/Hib at 15-18 Months (m) and Mencevax™ ACW at 24 to 30 m in Primed Subjects
The purpose of this study is to assess the safety and reactogenicity of a booster dose of diphtheria-tetanus-whole cell pertussis-hepatitis B virus/Haemophilus influenzae type b vaccine (DTPw-HBV/Hib) at 15-18 m and to assess the…
- Trial name
- NCT00317109
- Testing
- Tritanrix™- HepB, Hiberix™, Mencevax™ ACW
- Where
- 3 sites in South Africa
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation
This phase II trial studies how well olaparib works in treating patients with acute myeloid leukemia that has come back (relapsed) or does not respond to treatment (refractory), or myelodysplastic syndrome.
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia Post Cytotoxic Therapy, Recurrent Acute Myeloid Leukemia
- Trial name
- NCT03953898
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Olaparib
- Where
- 11 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Cancer Institute (NCI)
Focal Epilepsy
Priming the Epileptic Brain: tVNS to Improve Efficacy of add-on AED in Patients With Focal Epilepsy
The most prevalent neurological disorder with also immense burden of disease, epilepsy, is in over 30 percent of patients difficult to treat.
- Trial name
- PREP (NCT05180916)
- Testing
- TVNS
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Eindhoven University of Technology
Stress, Quality of Life
Caregiver Protocol for Remotely Improving, Monitoring, and Extending Quality of Life
The purpose of this study is to test an intervention to improve health promoting behaviors in family caregivers of patients receiving cancer therapy
- Conditions
- Stress, Quality of Life, Sleep Disturbance
- Trial name
- C-PRIME (NCT05379933)
- Testing
- Remote health coaching to improve self-care behaviors
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer
Biological Therapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Breast Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Peripheral stem cell transplantation combined with biological therapy may be an effective treatment for breast…
- Trial name
- NCT00002616
- Testing
- aldesleukin, filgrastim, carboplatin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Illinois Chicago
Type 2 Diabetes
Evaluating an Analogy-Based Consultation Approach for Insulin-Treated Type 2 Diabetes Patients
The goal of this retrospective interventional study is to learn whether a new consultation approach called M2-PRIME can help improve blood sugar control in people with type 2 diabetes who use insulin and have high blood sugar…
- Trial name
- ANALOGIES01 (NCT07265245)
- Testing
- M2-PRIME
- Where
- Malaysia
- Volunteers
- 106 people
- Sponsor
- Ministry of Health, Malaysia
in Vitro Maturation, FSH Priming
Non-FSH vs FSH-priming in Cycles With CAPA-IVM Treatment
In vitro oocyte maturation (IVM) is an assisted reproductive technology requiring minimal or no ovarian stimulation. In this technique, the immature oocytes were retrieved from follicles and subsequently cultured matured, meaning…
- Trial name
- NCT05600972
- Testing
- FSH priming
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- Mỹ Đức Hospital
HIV, Therapeutic Vaccine
Therapeutic Vaccine for HIV
Background: In most people who have human immunodeficiency virus (HIV), the immune system cannot control or cure the infection. Antiretroviral therapy drugs can keep the amount of HIV virus low for a long time.
- Trial name
- NCT01859325
- Testing
- rVSV, IL-12 pDNA adjuvant, HIV-Mag pDNA
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
High-Risk Cancer, Locally Advanced Breast Cancer
Three Fraction Radiation to Induce Immuno-Oncologic Response
Patients with high risk breast cancers (any locally advanced breast cancer patient defined as Stages IIB-III [excluding inflammatory breast cancer] with stage IIA being eligible for triple negative and HER2-positive breast…
- Trial name
- TRIO (NCT03978663)
- Testing
- Neoadjuvant radiotherapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetic Foot Ulcer
GrafixPL PRIME Evaluation Case Study
The investigators plan to evaluate healing in a cohort of patients with chronic wounds (n=40) that receive optimal treatment including serial wound debridement and off-loading with total contact casts or a boot and GrafixPL…
- Trial name
- NCT03742440
- Testing
- GrafixPL PRIME
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
IVF
Euploid Rate of Blastocyst Derived From PPOS VS Antagonist Protocol
In-vitro fertilization (IVF) involves multiple follicular development, oocyte retrieval and embryo transfer after fertilization.
- Trial name
- NCT04989348
- Testing
- Gonadotrophin releasing hormone antagonist protocol, Progestin-primed ovarian stimulation protocol
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
HIV Infections
Safety of and Immune Response to Polyvalent HIV-1 Vaccine in HIV Uninfected Adults
This study will evaluate the safety of and immune response to a new HIV vaccine. The vaccine in this trial uses pieces of HIV DNA and HIV proteins. The vaccine itself cannot cause HIV infection or AIDS.
- Trial name
- NCT00061243
- Testing
- HIV-1 DNA vaccine with protein vaccine boost
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)