Clinical trials: Priming
Chronic Hepatitis B
Prednisolone Priming Study in Patients With Chronic Hepatitis B
Study purpose: To investigate whether ALT rebound following corticosteroid priming enhances response to telbivudine therapy. Efficacy assessments: The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without…
- Trial name
- NCT00778596
- Testing
- Prednisolone
- Where
- 4 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- Yun-Fan Liaw
Acute Respiratory Failure
Effects of Different Crystalloid Solutions for Extra-corporeal Membrane Oxygenator (ECMO) Priming
Crystalloid solutions modify acid-base equilibrium according to their electrolyte composition. Moreover, it has been suggested that these alterations are generated by the difference between the solution strong ion difference…
- Trial name
- NCT02609360
- Testing
- Priming of ECMO circuit with 0.9% NaCl, Priming of ECMO circuit with Ringer Lactate, Priming of ECMO circuit with Balanced Solution
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bladder Cancer, Muscle-Invasive Bladder Carcinoma
Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer
This phase Ib/II trial studies the side effects, best dose, and effectiveness of enfortumab vedotin (EV) in combination with pembrolizumab and radiation therapy for treating patients with muscle invasive bladder cancer.
- Conditions
- Bladder Cancer, Muscle-Invasive Bladder Carcinoma, Stage II Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8
- Trial name
- NCT06470282
- Testing
- Enfortumab Vedotin, Pembrolizumab, Intensity Modulated Radiation Therapy (IMRT)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of California, San Francisco
Meningococcal Disease
PRIME Follow up - Quadri Meningo Vacinees
A previous cohort of 93 clinical trial participants received quadrivalent meningococcal conjugate vaccine, which includes strains ACW and Y, in their teenage years.
- Trial name
- PRIMEfollowup (NCT02811120)
- Testing
- venepuncture only
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Public Health England
Stroke
Virtual Reality as a Motor Priming Tool for Cognitive-Motor Rehabilitation Among Sub-Acute Stroke Patients
Stroke is the second leading global cause of mortality counting for 6.5 million deaths per annum. The global prevalence of stroke is increasing with an estimated prevalence of 33 million per year, affecting 1 out of 6 individuals…
- Trial name
- NCT04443127
- Testing
- Virtual Reality Training Session, Motor-Relearning Program
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Ziauddin University
Prehabilitation, Preoperative Care
Prehabilitation Before Major Surgery
The goal of this clinical trial is to learn if a virtually monitored, home-based prehabilitation program is feasible and acceptable for adults undergoing major elective surgery. The main questions it aims to answer are: 1.
- Conditions
- Prehabilitation, Preoperative Care, Elective Surgical Procedures, Postoperative Complications
- Trial name
- PRIME (NCT07590141)
- Testing
- Virtually Monitored Home-Based Prehabilitation Program
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Abdominal Aortic Aneurysm
TriVascular Canadian LIFE Study: Least Invasive Fast-Track EVAR (Endovascular Aneurysm Repair)
The primary objectives of the LIFE Study are to demonstrate the clinical cost and benefits associated with using the Ovation Prime Abdominal Stent Graft System under the least invasive conditions defined in the Fast-Track EVAR…
- Trial name
- NCT02451566
- Testing
- Ovation Prime Abdominal Stent Graft System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- TriVascular, Inc.
Stroke
Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke
This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.
- Trial name
- NCT06681207
- Testing
- anodal transcranial direct current stimulation (a-tDCS)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Infections, Meningococcal
Study to Evaluate GlaxoSmithKline (GSK) Biologicals' MenC-TT and Hib-MenC-TT or Meningitec™ in Healthy Toddlers
The purpose of this booster vaccination study is to evaluate the persistence and immune memory induced by a three-dose primary vaccination course with GSK Biologicals' MenC-TT (Neisseria meningitidis group C…
- Trial name
- NCT00135564
- Testing
- MenC-TT, Hib-MenC-TT
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Abdominal Aortic Aneurysm
TriVascular Post-Market Registry
This is a prospective observational post-market study of subjects receiving the Ovation™ or Ovation Prime™ Abdominal Stent Graft System ("Ovation™ or Ovation Prime™ Abdominal Stent Graft System Post-Market Study") in the…
- Trial name
- NCT01372709
- Testing
- Ovation™ or Ovation Prime™ Abdominal Stent Graft System
- Where
- 30 sites in Austria, Belgium and 6 more
- Volunteers
- 501 people
- Sponsor
- TriVascular, Inc.
COVID-19
Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults
This Phase 1 clinical trial will evaluate the safety, reactogenicity, and immunogenicity of PepGNP-COVID19, a synthetic nanoparticle-based, T cell-priming peptide vaccine against SARS-CoV-2, when administered as a booster dose in…
- Trial name
- NCT07183709
- Testing
- PepGNP-COVID19, Sterile Water for Injection
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sterility
Endometrial Priming for Embryo Transfer
The aim of this trial is compare two different endometrial priming protocols women that receive oral estrogens women that receive transdermal estrogens
- Trial name
- NCT01430650
- Testing
- Oral strogen, Transdermal strogen
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Parc de Salut Mar
HIV-1-infection
A Study to Evaluate the Safety and Immunogenicity of the V3-region Directed Immunogens DV700P-RNA Followed by DV701B1.1-RNA in Adults Without HIV
This is a phase 1, first-in-human (FIH) trial for two vaccines, DV700P-RNA and DV701B1.1-RNA. This means it is the first time these study products are being tested in people.
- Trial name
- NCT06919016
- Testing
- DV700P-RNA, DV701B1.1-RNA
- Where
- 8 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Viral Diseases
Identification of Viruses Associated With Diseases of Unknown Cause
This study will try to identify new or known viruses responsible for diseases or conditions of unknown cause. Viruses are an important cause of illness.
- Trial name
- NCT00359268
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco
Breast Cancer
PRospective Study to Measure the Impact of MammaPrint on Adjuvant Treatment in Hormone Receptor-positive HER2-negative Breast Cancer Patients (PRIMe)
PRIMe is a prospective, case-only trial designed to measure the impact of MammaPrint on physician chemotherapy intention in the two discordant groups (ET/POOR, CT/GOOD) in stage 1 and 2 HR-positive HER2-negative breast cancer…
- Trial name
- PRIMe (NCT02269813)
- Testing
- MammaPrint, BluePrint, TargetPrint
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 452 people
- Sponsor
- Women's Cancer Study Group GmbH
Hemorrhagic Fever, Ebola
Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo
The purpose of this study is to assess the safety, tolerability and immunogenicity of different vaccination schedules of Ad26.ZEBOV and MVA-BN-Filo administered intramuscularly (IM) as 2-dose heterologous regimens in healthy and…
- Trial name
- NCT02598388
- Testing
- Ad26.ZEBOV, MVA-BN-Filo
- Where
- 7 sites in United States, Kenya and 4 more
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Carcinoma, Non-Small Cell Lung, Carcinoma, Small Cell Lung
Neoantigen-primed DC Vaccines Therapy for Refractory Lung Cancer
Various of immunotherapies are now widely applied in the treatment of lung cancer. Neoantigens arising from the mutations of the tumor genome expressed specifically on the tumor cell instead of normal cells, suggesting that…
- Trial name
- NCT03871205
- Testing
- Neoantigen loaded DC vaccine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen People's Hospital
Neuroendocrine Tumor of Pancreas, Multiple Endocrine Neoplasia Type 1
Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients
Patients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET).
- Trial name
- PRIME (NCT05037461)
- Testing
- High-dose-high precision MR-guided radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- J.M. de Laat
Tobacco Use Disorder
Modification of Goal-directed and Habitual Behavior in Addiction
This study aims to examine the modification of the hypothesized imbalance between goal-directed and habitual behavior and its neural correlates in smokers.
- Trial name
- NCT03764969
- Testing
- standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), Implicit computer-based habit-modifying training (ICHT)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Central Institute of Mental Health, Mannheim