Clinical trials: Priming
Dengue Fever
A Study to Monitor the Adverse Events of QDENGA Vaccine in Participants in Malaysia
The main aim of this study is to collect the number and type of medical problems (adverse events) after vaccination with QDENGA in Malaysia and to learn more about such medical problems after vaccination.
- Trial name
- PRIME-Q (NCT06388785)
- Testing
- No Intervention
- Where
- 2 sites in Malaysia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Takeda
Multiple Myeloma and Plasma Cell Neoplasm
Filgrastim Compared With Sargramostim Plus Chemotherapy, Peripheral Stem Cell Transplantation, and Interferon Alfa in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and…
- Trial name
- NCT00005987
- Testing
- carmustine, cyclophosphamide, dexamethasone
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Heart Failure, Systolic
Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction（PRIME-HFrEF Study）
This study is an exploratory clinical study to observe the safety and efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in the heart failure patients with reduced ejection fraction.
- Trial name
- PRIME-HFrEF (NCT04992832)
- Testing
- human umbilical cord mesenchymal stem cells, human serum albumin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai East Hospital
Corona Virus Infection
BBV152/BBV154 Heterologus Prime-Boost Study
All participants will be assessed for immunogenicity and safety endpoints and provide a blood sample before the administration of the first dose of IP.
- Trial name
- BBV152BBV154 (NCT05639998)
- Testing
- COVAXIN(BBV152), BBV154 Intranasal Vaccine
- Where
- 11 sites in India
- Volunteers
- 608 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
Anemia, Cognitive; Disorder, Due to General Medical Condition
Haemo-autologous Antegrade Repriming (HAR) as Minimum Impact Perfusion Strategy for Cardiopulmonary Bypass
Haemo-autologous Antegrade Repriming (HAR) is a procedure based in the combination of evidence proven measures designed to reduce the haemodilution caused by establishing the cardiopulmonary bypass (CPB) during cardiac surgery.
- Conditions
- Anemia, Cognitive; Disorder, Due to General Medical Condition, Embolism, Air, Transfusion
- Trial name
- HARjbm1 (NCT03720184)
- Testing
- HAR
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Juan Blanco Morillo
Fluid Overload and Hypertension in Hemodialysis Patients
Effect of Sodium Concentration of Priming and Rinsing Fluids on Weight Gain
Sodium loading during hemodialysis treatment is common and may contribute to increased interdialytic weight gain and hypertension.
- Trial name
- NCT01168947
- Testing
- 5% dextrose solution
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Renal Research Institute
Coronary Heart Disease
ORSIRO Stents Versus Xience PRIME Stents Assessed by Optical Coherence Tomography
This prospective, randomized trial will compare the extent of covered stent strut segments by assessed by Optical Coherence Tomography (OCT) of the ORSIRO DES with that of the XIENCE PRIME DES, which is the standard of choice of…
- Trial name
- ORSIRO_OCT (NCT01594736)
- Testing
- ORSIRO, XIENCE PRIME DES
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Alpha-1 Antitrypsin Deficiency, Alpha-1 Antitrypsin Deficiency-associated Lung Disease
A Study of the Safety and Efficacy of Prime Editing (PM647a) in Participants With Alpha-1 Antitrypsin Deficiency
The purpose of this study is to evaluate the safety, tolerability, biological activity, and initial efficacy of PM647a, an investigational Prime Editing therapy, in adults and adolescents with Alpha-1 Antitrypsin Deficiency…
- Conditions
- Alpha-1 Antitrypsin Deficiency, Alpha-1 Antitrypsin Deficiency-associated Lung Disease, Alpha-1 Antitrypsin Deficiency (AATD), AATD
- Trial name
- PM647a (NCT07887347)
- Testing
- PM647a
- Volunteers
- 54 people
- Sponsor
- Prime Medicine, Inc.
COVID-19, SARS-CoV-2
Safety and Immunogenicity of COVI-VAC as a Booster Dose in Adults Previously Vaccinated Against COVID-19
The purpose of this study is to to evaluate the safety and immune response of COVI-VAC given as a single booster dose in healthy adults previously vaccinated against COVID-19 with an authorised mRNA or adenovirus-vectored…
- Trial name
- NCT05233826
- Testing
- COVI-VAC
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Codagenix, Inc
In-stent Restenosis
DARE-trial: A Trial Studying the Effect of the SeQuent Please Drug-eluting Balloon Compared to the Xience Prime Drug-eluting Stent for the Treatment of Stenosis of an Earlier Implanted Stent.
The main objective of the study is to determine whether PCI for in-stent restenosis with a drug eluting balloon is angiographically non-inferior to PCI with a drug eluting stent at 6 month follow up.
- Trial name
- NCT01127958
- Testing
- PCI with a drug-eluting balloon, PCI with a drug-eluting stent
- Where
- 8 sites in Netherlands
- Volunteers
- 270 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Myeloid Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Clofarabine, Cytarabine, and G-CSF in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy, such as clofarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or stopping them from dividing.
- Conditions
- Acute Myeloid Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Trial name
- NCT00602225
- Testing
- clofarabine, cytarabine, filgrastim
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Coronary Artery Disease
Assessment of Stent Malapposition and Neointimal Coverage on Optical coHerence Tomography at Post-procedure and 3 Months After Platinum Chromium Alloy Of the Element™ Stent Implantation
The purpose of this study is to compare the degree of stent malapposition on an immediate optical coherence tomography (OCT) after nominal stent pressure and at a final post-procedure OCT (ANCHOR-I) and the neointimal coverage on…
- Trial name
- ANCHOR (NCT01581515)
- Testing
- Promus Element everolimus eluting coronary stent, Xience Prime everolimus eluting coronary stent
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
HIV Infections
Study of Boosting Strategies After Vaccination With ALVAC-HIV and AIDSVAX® B/E
The primary purpose of the study is to better define the relative contributions of AIDSVAX® B/E alone, ALVAC-HIV alone, or ALVAC-HIV plus AIDSVAX® B/E combination to the observed immune profile in the weeks and months after…
- Trial name
- NCT01931358
- Testing
- ALVAC-HIV, AIDSVAX B/E
- Where
- 3 sites in Thailand
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
HIV Infections
Evaluating the Safety and Immune Response to Three Different Prime-Boost HIV Vaccine Regimens in Healthy, HIV-Uninfected Adults
The purpose of this study is to test the safety and immune response to three different sets of HIV vaccines in healthy, HIV-uninfected adults.
- Trial name
- NCT01970449
- Testing
- DNA Nat-B env vaccine, NYVAC Nat-B env vaccine, DNA CON-S env vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HPV Infection, CIN1
Prime-boost Vaccine Study in Women With Low-grade Cervical HPV Lesions
A Phase 1b/2 multi-centre study evaluating the safety, efficacy and immunogenicity of prime-boost vaccines ChAdOx1-HPV and MVA-HPV in women with HPV related low grade cervical lesions.
- Trial name
- NCT04607850
- Testing
- ChAdOx1-HPV, MVA-HPV
- Where
- 16 sites in Belgium, Estonia and 1 more
- Volunteers
- 108 people
- Sponsor
- Barinthus Biotherapeutics
Pathological Gambling
D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement
To determine if: 1. pathological gambling is similar to psychostimulant addiction as reflected by parallel roles for D1 and D2 receptors in gambling and stimulant reinforcement. 2.
- Trial name
- HFDEX (NCT02203786)
- Testing
- Haloperidol, Fluphenazine, Dexedrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Depression
Priming Attachment Security Within an IAPT Setting
There is growing evidence that priming attachment security is associated with improved attitudes towards therapy, increased engagement and decreased levels of depression and anxiety.
- Trial name
- NCT04022759
- Testing
- Treatment as Usual with Security Prime, Treatment as Usual (Behavioural Activation)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Chronic Hepatitis B
Prednisolone Priming Study in Patients With Chronic Hepatitis B
Study purpose: To investigate whether ALT rebound following corticosteroid priming enhances response to telbivudine therapy. Efficacy assessments: The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without…
- Trial name
- NCT00778596
- Testing
- Prednisolone
- Where
- 4 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- Yun-Fan Liaw
IVF, PCO
Progesterone Primed Protocol Versus GnRH Antagonist in With PCO Undergoing ICSI
To compare the effectiveness and safety of Progesterone Primed Ovarian Stimulation protocol (PPOS) using Dydrogestrone vs GnRH Antagonist Protocol in patients with expected high ovarian response undergoing ICSI cycle
- Trial name
- NCT05951400
- Testing
- Dydrogesterone Tablets, Cetrorelix
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
COVID-19
Safety and Immunogenicity Study in Adults of AZD1222 and rAd26-S Administered as Heterologous Prime Boost Regimen for the Prevention of Coronavirus Disease 2019 (COVID-19)
This is a Phase I/II, parallel group, single blinded (participant blinded), randomised study assessing the immunogenicity and safety of AZD1222 and rAd26-S administered as heterologous prime-boost in alternating order in 2 study…
- Trial name
- NCT04760730
- Testing
- AZD1222, rAd26-S
- Where
- United Arab Emirates
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- R-Pharm