Clinical trials: Priming
Hepatocellular Carcinoma (HCC)
Electronic Symptom Monitoring of Patient-Reported Outcomes Among Patients With Hepatocellular Carcinoma During Immunotherapy (PRIME-HCC): Protocol for a Randomised Controlled Trial
The goal of this clinical trial is to design a digital PRO intervention model applicable to patients with hepatocellular carcinoma, and The main questions it aims to answer are: Can symptom management through patients' regular…
- Trial name
- NCT06938945
- Testing
- Digitized patient-reported outcomes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Wei Xiaoping
Stroke, Hemiparesis After Stroke
Optimizing Cortical Priming
Each year over 795,000 people suffer from stroke resulting in the primary cause of adult disability. Persistent upper limb dysfunction due to stroke significantly impairs performance and results in a serious decline of quality of…
- Trial name
- NCT07860073
- Testing
- 5 Hz Repetitive transcranial magnetic stimulation (rTMS) on the contralesional dorsal premotor cortex (cPMd), 5 Hz Repetitive transcranial magnetic stimulation (rTMS) on the ipsilesional primary motor cortex (iM1)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wan-Wen Liao
Prehabilitation, Preoperative Care
Prehabilitation Before Major Surgery
The goal of this clinical trial is to learn if a virtually monitored, home-based prehabilitation program is feasible and acceptable for adults undergoing major elective surgery. The main questions it aims to answer are: 1.
- Conditions
- Prehabilitation, Preoperative Care, Elective Surgical Procedures, Postoperative Complications
- Trial name
- PRIME (NCT07590141)
- Testing
- Virtually Monitored Home-Based Prehabilitation Program
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Avian Influenza, Influenza Immunisation
2013/2017 H7N9 Prime-Boost Interval
This is a trial designed to assess the safety, reactogenicity and immunogenicity of one or two doses of monovalent inactivated split influenza 2013 and 2017 A/H7N9 virus vaccines administered intramuscularly at different dosages…
- Trial name
- NCT03589807
- Testing
- A/H7N9, AS03, Influenza Virus Vaccine, Monovalent A/H7N9 A/Shanghai/2/2013
- Where
- 6 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Haemophilus Influenzae Type b, Neisseria Meningitidis
Safety, Reactogenicity & Immunogenicity Study to Evaluate a Booster Dose of GSK Biologicals' Hib-MenC Given With Priorix™ in Toddlers (13-14 m) Primed With 3 Doses of Hib and MenC-CRM197
The purpose of this study is to evaluate the safety, reactogenicity and immunogenicity of a booster dose of the candidate Hib-MenC conjugate vaccine given concomitantly with measles, mumps and rubella (MMR) vaccine, versus…
- Trial name
- NCT00263653
- Testing
- Haemophilus influenzae type b- and meningococcal (vaccine)
- Where
- 16 sites in Spain
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cerebral Palsy, Spastic, Transcranial Magnetic Stimulation, Repetitive
Priming Effects of Ultra-high Frequency Quattro Pulse Transcranial Brain Stimulation Prior to Hand Motor Function Training in Children With Unilateral Spastic Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) leads to life-long impairment with a hemiparesis of the affected side of the body. Rehabilitation efforts combine evidence based methods such as constrained induced movement therapy (CIMT)…
- Trial name
- TRAINCP (NCT05165472)
- Testing
- Quadri-pulse theta burst stimulation
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Technical University of Munich
Pancreatic Cancer
DNA Mutation Detection in Circulating Tumor DNA and Tissue by mmADPS for Pancreatic Cancer
Based on the cell free nucleic acid analysis information of blood samples and genetic mutation profile of EUS-FNB tissue from pancreatic cancer, the concordance between them is evaluated.
- Trial name
- NCT05604573
- Testing
- cell free DNA in blood, genetic mutation in tissue
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cerebral Palsy (CP), Unilateral Cerebral Palsy
Carry-Over Effects of Lower Limb Cross-Training Priming on Upper Limb Function in Children With Unilateral Cerebral Palsy
PURPOSE: The purpose of this randomized controlled trial was to investigate the potential carry-over effects of a 6-week lower limb strengthening-based cross-training (CT) priming protocol, added to standard physical…
- Trial name
- CROSS-UP (NCT07525752)
- Testing
- Standard rehabilitation program, Lower Limb Cross-Training Priming
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Multiple Myeloma
Id-KLH Vaccine + T Cells in Subjects With Myeloma Undergoing Transplant
This study will enroll myeloma subjects undergoing autotransplantation. The primary objective of this study is to evaluate whether infusions of Id-KLH primed CD3/CD28 activated autologous lymphocytes mediate a more intense…
- Trial name
- NCT01426828
- Testing
- CD3/CD28
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
HIV-1-infection
A Study to Evaluate the Safety and Immunogenicity of the V3-region Directed Immunogens DV700P-RNA Followed by DV701B1.1-RNA in Adults Without HIV
This is a phase 1, first-in-human (FIH) trial for two vaccines, DV700P-RNA and DV701B1.1-RNA. This means it is the first time these study products are being tested in people.
- Trial name
- NCT06919016
- Testing
- DV700P-RNA, DV701B1.1-RNA
- Where
- 8 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Major Depression
PRIME Care (PRecision Medicine In MEntal Health Care)
The focus of this application is on the impact of providing depressed Veterans and their providers with the results of pharmacogenetic (PGx) testing for psychotropic medications.
- Trial name
- PRIME Care (NCT03170362)
- Testing
- Pharmacogenetic Test
- Where
- 24 sites in United States
- Volunteers
- 1,944 people
- Sponsor
- VA Office of Research and Development
Type 1 Diabetes Mellitis
Effectiveness of Artificial-Intelligence (AI) Bolus Priming Added to an Existing Fully Automated Control Algorithm (AIDANET)
Bolus Priming (BP) based on Artificial Intelligence (AI) learning of meal patterns, added to our established Automated insulin delivery as Adaptive Network (AIDANET) algorithm and running on iPhone Diabetes Assistant (iDiAs)…
- Trial name
- AIDANET AI (NCT07517770)
- Testing
- Hybrid Closed Loop (HCL) x 2 weeks, AIDANET x 2 weeks, AIDANET AI x 4 weeks
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sue Brown
Cardiovascular Diseases, Stroke
Hybrid Stroke Rehab With Mirror Priming
This trial aims to examine the effects of enhanced mirror priming, overcoming the limitations of traditional mirror therapy, to achieve optimization and personalized intervention.
- Conditions
- Cardiovascular Diseases, Stroke, Cerebrovascular Disorders
- Trial name
- NCT07324278
- Testing
- Mirror priming, Conventional therapy
- Where
- Taiwan
- Volunteers
- 81 people
- Sponsor
- I-Shou University
Infections, Streptococcal
Immunological Persistence After Priming With GSK1024850A Vaccine and Safety& Immunogenicity After Booster Dose
This primary purpose of this study is the evaluation of the immunological persistence following completion of the 3-dose primary vaccination course with either a clinical or a commercial lot of pneumococcal conjugate vaccine…
- Trial name
- NCT01119625
- Testing
- Pneumococcal vaccine GSK1024850A, Infanrix-IPV/Hib
- Where
- 3 sites in Singapore
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Controlled Ovarian Hyperstimulation, Polycystic Ovarian Syndrome
Progesterone Primed Ovarian Stimulation Versus GnRH Antagonist Protocols in Women With Polycystic Ovarian Syndrome
The purpose of this study is to compare the use of the progesterone-primed ovarian stimulation protocol versus GnRH antagonist protocol in women with polycystic ovarian syndrome (PCOS) regarding the number of oocytes retrieved…
- Trial name
- NCT06812559
- Testing
- Progesterone, GnRH antagonist (Cetrorelix)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- El Shatby University Hospital for Obstetrics and Gynecology
Plasmodium Falciparum Malaria
CS DNA MVA Trial in Mampong, Ghana
The purpose of this study is to evaluate the safety, tolerability, and effectiveness of 2 doses of a malaria vaccine (DNA) followed by a dose of another type of malaria vaccine (MVA) given as a "booster." Forty-eight adults in…
- Trial name
- NCT00377494
- Testing
- MVA-CSO Vaccine, PfCSP DNA (VCL-2510) Vaccine
- Where
- 2 sites in United States, Ghana
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Leukemia, Myelodysplastic Syndromes
Interferon γ-Primed Mesenchymal Stromal Cells as Prophylaxis for Acute Graft v Host Disease
The protocol is a phase I open label study evaluating the safety and feasibility of peri-transplant infusion of freshly expanded interferon gamma primed MSCs in adult and pediatric patients undergoing HCT for acute leukemia and…
- Trial name
- NCT04328714
- Testing
- Interferon gamma (IFNγ)-primed human bone marrow-derived mesenchymal stromal cells
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Edwin Horwitz
Healthy
A Safety and Immunogenicity Study of Heterologous and Homologous Prime-Boost Ebola Vaccine Regimens in Healthy Participants
The purpose of this study is to test the safety and immunogenicity of MVA-BN-Filo and Ad26.ZEBOV as heterologous and homologous prime-boost vaccine regimens in healthy adult participants.
- Trial name
- NCT02325050
- Testing
- MVA-BN-Filo, Ad26. ZEBOV
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Meningococcal Immunisation, Healthy Volunteers
Study on an Investigational Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Administered as a 5- and/or 10-year Booster Doses in Children and Adolescents Vaccinated 5 or 10 Years Earlier as Toddlers
The purpose of the MEQ00073 study is to describe the immunogenicity and safety of a booster dose and persistence of a priming dose of MenACYW conjugate vaccine (MenQuadfi®) in adolescents who had been vaccinated approximately 10…
- Trial name
- NCT04936685
- Testing
- Meningococcal Polysaccharide (Serogroups A, C, W, and Y) Tetanus Toxoid Conjugate Vaccine
- Where
- 27 sites in Finland, Germany and 2 more
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Missed Menstrual Period
Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills"
This study will assess the effectiveness and acceptability of a 3-day missed period pill regimen.
- Trial name
- NCT04676776
- Testing
- Levonorgestrel, Mifepristone
- Where
- Mexico
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects