Clinical trials: Probe-based Confocal Laser Endomicroscopy
Undifferentiated Gastric Cancer
Role of Probe-based Confocal Laser Endomicroscopy Targeted Biopsy in the Molecular Study of Undifferentiated Gastric Cancer
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02799420
- Testing
- GastroFlex UHD, Cellvizio; Mauna Kea Technologies, Paris, France, white light endoscopy (WLE)
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Pancreatic Cysts
Confocal Endomicroscopy of Pancreatic InVivo
Confocal laser endomicroscopy (CLE) is a novel and highly promising imaging method for that allows in vivo imaging of the mucosal layer at resolution of approximately 1 micron.
- Trial name
- NCT01035008
- Testing
- Endoscopic Ultrasound (EUS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Esophageal Neoplasms, Artificial Intelligence
Automatic Diagnosis of Early Esophageal Squamous Neoplasia Using pCLE With AI
Detection and differentiation of esophageal squamous neoplasia (ESN) are of value in improving patient outcomes. Probe-based confocal laser endomicroscopy (pCLE) can diagnose ESN accurately.However this requires much experience…
- Conditions
- Esophageal Neoplasms, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04136236
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Shandong University
Pleural Carcinomatosis
Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Malignancies Diagnosis.
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies").
- Trial name
- NCT03805971
- Testing
- Study of the pleural cavity with a confocal laser endomicroscope.
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University of Liege
Gastric Cancer, Intestinal Metaplasia
New Classification of Stomach Using Probe-based Confocal Laser Endomicroscopy
The aim of the present study was to propose a new pCLE classification of gastric pit patterns and vessel architecture, and to assess the accuracy and interobserver agreement of this new pCLE classification system in the stomach.
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis, Inflammation
- Trial name
- NCT01896310
- Testing
- probe-based confocal laser endomicroscopy
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Shandong University
Ulcerative Colitis, Artificial Intelligence
Automatic Evaluation of Inflammation Activity in Ulcerative Colitis Using pCLE With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables to evaluate the inflammation activity of ulcerative colitis with excellent correlation with histopathology.
- Conditions
- Ulcerative Colitis, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04131530
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Intestinal Dysplasia
Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy
The investigators hypothesis that 1. clinical applicability and overall diagnostic sensitivity and specificity of pCLE for diagnosing gastric preneoplastic and neoplastic lesions is acceptable 2.
- Trial name
- pCLE-GCEP (NCT01398579)
- Testing
- Gastroscopy
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Flow Determination
Real-time Observation of Microcirculatory Hemodynamics in Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The morphologic change of microvessels has the clinical value to distinguish cancerous from non-cancerous mucosa. The aim of this study was to observe gastric mucosa microcirculatory hemodynamic changes real-time using pCLE…
- Trial name
- NCT02595151
- Testing
- CLE
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shandong University
Gastric Cancer
A Pilot Study on Usefulness of Probe-based Confocal Laser Endomicroscopy Targeted Gastric Biopsy
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02089373
- Testing
- Probe-based confocal laser endomicroscopy, White light endoscopy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Gastrointestinal Imaging With pCLE
Effect of Buscopan on Gastrointestinal Imaging Quality With Probe-based Confocal Laser Endomicroscopy
Gastrointestinal cancer has developed into a serious health problem in China. 80%-90% patients were detected at middle and later stage. The five-year survival rate for advanced cancer patients is less than 10%.
- Trial name
- NCT02725398
- Testing
- Buscopan, Scopolamine, physiological saline
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Early Gastric Cancer
Usefulness of Probe-based Confocal Laser Endo-microscopy in Delineation of Margin of Early Gastric Cancer for Endoscopic Submucosal Dissection
The aim of this study is to evaluate the usefulness of pCLE (probe-based confocal laser endomicroscopy) compared with conventional chromoendoscopy (CE) for delineating the margin of early gastric cancer (EGC) with endoscopic…
- Trial name
- NCT02189226
- Testing
- Endoscopic submucosal dissection (ESD) with or without probe-based confocal laser endomicroscopy (pCLE)
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Yonsei University
Lower Gastrointestinal Disorders
Validation of Clinical Efficacy and Development of New Diagnostic Algorithm of Probe-based Confocal Laser Endomicroscopy in Patients With Lower Gastrointestinal Disorder
The aims of this research are to validate and develop of therapeutic strategies for patients with colorectal lesions in real time through pCLE(probe-based confocal laser endomicroscopy).
- Trial name
- NCT02091895
- Testing
- probe-based confocal laser endomicroscopy
- Where
- South Korea
- Volunteers
- 311 people
- Sponsor
- Yonsei University
Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence
Automatic Classification of Colorectal Polyps Using Probe-based Endomicroscopy With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables real-time histological evaluation of gastrointestinal mucosa during ongoing endoscopy examination.
- Conditions
- Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence, Colorectal Polyps
- Trial name
- NCT03787784
- Testing
- AI presentation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Diffuse Parenchymal Lung Diseases
Validation of Alveolar Probe-based Confocal Laser Endomicroscopy Descriptors in Diffuse Parenchymal Lung Diseases
Diffuse parenchymal lung diseases (DPLD) include a variety of respiratory conditions that affect either the pulmonary interstitium or the alveolar space .
- Trial name
- Microsemio-PI (NCT02961335)
- Testing
- Bronchoscopy, Confocal microendoscopy, Biopsy sampling
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Rouen
Cervix Cancer, Endometrium Cancer
Probe-based and Needle-based Confocal Laser Endomicroscopy During Gynaecological Procedures.
The protocol aims at demonstrating the technical feasibility and safety of doing endomicroscopic imaging (both probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy, nCLE) during…
- Conditions
- Cervix Cancer, Endometrium Cancer, Ovarian Cancer, Carcinoma in Situ of Fallopian Tube
- Trial name
- NCT02221076
- Testing
- Confocal Laser Endomicroscopy (CLE)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Mauna Kea Technologies
Inflammation
Evaluation of Inflammation Activity in Ulcerative Colitis by pCLE
The aim:1) To test the correlation of pCLE-obtained features with histological findings in UC; comparing the real-time conventional colonoscopy Baron score with CLE assessment.
- Trial name
- NCT03788824
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shandong University
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Rectal Cancer
Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy.
- Trial name
- NCT05316103
- Testing
- Probe-based confocal laser endomicroscopy targeted optical biopsy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Colon Polyps, Adenomatous Polyps
Prospective Study for Evaluating Colon Polyp Histology With in Vivo Probe Based Confocal Laser Endomicroscopy
Chromoendoscopy (that involves spraying of dyes over the colonic mucosa) combined with magnification has been utilized for polyp histology identification.
- Conditions
- Colon Polyps, Adenomatous Polyps, Colon Cancer
- Trial name
- NCT01214031
- Testing
- Confocal laser endomicroscopy (CLE)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Midwest Biomedical Research
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
Endomicroscopy in Primary Sclerosing Cholangitis Related Inflammatory Bowel Disease Surveillance
Evaluation of the efficacy of laser-based endomicroscopy as a complement to white-light colonoscopy and chromoendoscopy for early detection of colon dysplasia in patients with PSC-IBD.
- Trial name
- pCLE-PSC-IBD (NCT01880606)
- Testing
- colonoscopy with endomicroscopy
- Where
- Sweden
- Volunteers
- 69 people
- Sponsor
- Karolinska University Hospital