Clinical trials: Probiotic
Common Infectious Diseases
Effect of the Consumption of a Fermented Milk on Common Infections in Children Aged 3-6 Years, Attending Day Care Centers
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Trial name
- NCT01200173
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- Russia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Respiratory Tract Infections
Measuring the Influence of Kefir on Children's Stools on Antibiotics (MILK)
The purpose of this study is to determine the effectiveness of commercially available kefir on preventing antibiotic-associated diarrhea compared to placebo in children ages 1-5.
- Trial name
- MILK (NCT00481507)
- Testing
- Kefir
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Healthy
Probiotics to Enhance Immunogenicity of Influenza Vaccine in Healthy Adults
The purpose of this study is to determine whether the food supplement called Lactobacillus rhamnosus GG (LGG) may help boost the effectiveness of the nasal flu vaccine.
- Trial name
- NCT00620412
- Testing
- Lactobacillus rhamnosus, Influenza Virus Vaccine Live, Intranasal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Probiotic Intervention
Probiotic Intervention, Bile Acids and Lipid Metabolism Metabolic Profile in Healthy Overweight Subjects.
Moderate hypercholesterolemia, metabolic alterations derived from overweight or obesity, and consequently and their related cardiovascular risks can be reduced through changes in lifestyle.
- Trial name
- PROBILIP (NCT05378230)
- Testing
- Probiotic preparation of three Lactobacillus plantarum strains (CECT 7527, CECT 7528, CECT 7529)
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stool Frequency
A Prospective, Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy of Bacillus Coagulans Unique IS2 on Improving Bowel Movement Characteristics, Gastrointestinal-related Symptoms and Quality of Life in Healthy Adult Participants
This prospective, randomized, placebo-controlled, double-blind study will be conducted to assess the efficacy of 2 billion CFU/day of B.
- Trial name
- NCT05123664
- Testing
- Capsule
- Where
- Canada
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Functional Constipation
Probiotics for Constipation Relief in Adults
This study aims to evaluate the efficacy and safety of Bifidobacterium animalis subsp. lactis BLa36 in adults with functional constipation.
- Trial name
- NCT07507955
- Testing
- Probiotic, Maltodextrin, High-activity probiotic group
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Mental Health Wellness
Effects of a Probiotic on Aspects of Mental Wellness
The goal of this clinical trial is to compare the effect of a probiotic strain on mental wellbeing in moderately stressed, healthy, adults in the general population.
- Trial name
- NCT05905679
- Testing
- Dietary Supplement: Probiotics
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Premature; Infant, Light-for-dates, Breastfeeding
Probiotics and Early Microbial Contact in Preterm Neonates
Probiotics are live microbes which, when administered in sufficient amounts, confer a health benefit to the host. According to recent clinical trials, administration of probiotics to very low birth weight infants significantly…
- Trial name
- ProPre (NCT01454661)
- Testing
- LGG, LGG+Bb-12
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Bacterial Vaginosis Treatment
Vaginal Clindamycin Cream Plus Vaginal Probiotic for Bacterial Vaginosis
Vaginal Clindamycin Cream Plus Vaginal probiotic for treatment of Bacterial Vaginosis
- Trial name
- NCT03234517
- Testing
- Vaginal Clindamycin Cream, Vaginal Probiotic
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Vaginal Infection
Interventional Study to Evaluate the Effect of the Oral Administration of L.Plantarum on Vaginal Microbiota
Vaginal microbiota is abundantly colonized by Lactobacillus genera. When vaginal microbiota gets altered, opportunistic microorganisms may proliferate and become abundant species giving rise to dysbiosis.
- Trial name
- NCT04461782
- Testing
- Lactobacillus plantarum
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Gut Microbiota Diversity and Composition, Gut Microbiota Modulation
Effects of Barley and Kefir on Gut Microbiota in Physically Active Adults
The purpose of this randomized controlled clinical trial is to investigate whether a four-week dietary intervention consisting of a daily meal with barley and kefir can influence gut microbiota diversity and composition in…
- Conditions
- Gut Microbiota Diversity and Composition, Gut Microbiota Modulation, Probiotic, Prebiotic
- Trial name
- GUTS (NCT07864779)
- Testing
- Barley, Kefir
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western Norway University of Applied Sciences
Influenza Vaccination, Immune Response
Effects of Lactobacillus Coryniformis CECT5711 on Immune Response to Influenza Vaccination in Adults Over 65.
The objective of the present study is to evaluate the capability of the probiotic strain Lactobacillus coryniformis K8 CECT5711 (Lc K8) to enhance the immune response to influenza vaccine in elderly and the effect on respiratory…
- Conditions
- Influenza Vaccination, Immune Response, Probiotics
- Trial name
- NCT03167593
- Testing
- Lactobacillus coryniformis K8 CECT5711
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Safety Issues
Tolerance of a Probiotic Formula
Evaluate the tolerance of a probiotic formula in infants
- Trial name
- NCT03925558
- Testing
- Probiotics
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Probi AB
Allergic Conditions
Primary Prevention of Allergic Disease in Early Child by Lactobacillus Reuteri
An altered microbial exposure may be partly responsible for the increase of allergic diseases in populations with a western lifestyle.
- Trial name
- NCT01285830
- Testing
- Lactobacillus reuteri
- Where
- 3 sites in Sweden
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Antibiotic Associated Diarrhea, Acute Otitis Media
Effects of Saccharomyces Boulardii CNCM I-745 on Antibiotic-Associated Perturbation in Children Treated for Acute Respiratory Infections (RESTORE Study)
This study aims to evaluate the effect of co-administering the probiotic Saccharomyces boulardii CNCM I-745 with amoxicillin-clavulanic acid on the intestinal and nasopharyngeal microbiota in children diagnosed with acute otitis…
- Conditions
- Antibiotic Associated Diarrhea, Acute Otitis Media, ACUTE SINUSITIS
- Trial name
- RESTORE (NCT07015736)
- Testing
- Amoxicillin-Clavulanic acid 600mg - 42.9 mg/ 5 mL oral suspension, Saccharomyces boulardii CNCM I-745
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Obesity
Effect of a Synbiotic Supplement on a High-protein Diet
The objective of the trial is to study how a synbiotic treatment will affect weight loss and management in individuals enrolled in weight loss diet Profile®.
- Trial name
- NCT03123510
- Testing
- Bifidobacterium spp plus bimuno- galacto-oligosaccharides
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Sarcopenia
The Characteristics of Gut Microbiota in Patients With Sarcopenia and the Development of Probiotics
The primary aim of this study is to identify the composition and characteristics of the gut microbiota in patients with sarcopenia in older adults, and compare these with the gut microbiota characteristics of older adults and…
- Trial name
- NCT07334210
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Obesity
Effects of a Probiotic on Body Weight
Probiotics administration is associated with health benefits on gut barrier integrity and immunological functions of the gastrointestinal tract.
- Trial name
- NCT01106924
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Laval University
Gestational Diabetes Mellitus in Pregnancy
Impact of Oral Probiotic Blend on Pregnancy Outcome
The aim of this study is, to investigate the effect of oral intake of Lactobacillus rhamnosus GG (ATCC 53103), Lactobacillus crispatus Lbv88, Lactobacillus rhamnosus Lbv96, Lactobacillus jensenii Lbv116 Lactobacillus gasseri…
- Trial name
- NCT04009889
- Testing
- capsule containing a probiotic blend of 5 different Lactobacilli, capsule containing Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, but no probiotics.
- Where
- Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- i-Health, Inc.
Obesity, Childhood
Gut Microbiome, Adiposity, and Probiotics (GMAP)
Recent studies have shown that the bacteria in the gut (gut microbiome) can affect adiposity levels and inflammation. In animal studies, changing these bacteria has been linked with decreased fat mass and inflammation as well as…
- Trial name
- GMAP (NCT03533621)
- Testing
- Probiotic - VSL#3
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
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