Clinical trials: Probiotic Intervention
Cardiometabolic Risk Factors
Effect of Probiotics on Cardiometabolic Health
Atherosclerosis is a major risk factor for cardiovascular diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of atherosclerosis.
- Trial name
- NCT05005754
- Testing
- Probiotics
- Where
- 2 sites in China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infant, Newborn, Immunity
The Bloom Infant Probiotic (BIP) Study
The goal of this clinical trial is to investigate whether administering a probiotic (Infloran®) to infants who received antibiotics in the first 28 days of life can restore or enhance their immune response to routine vaccines.
- Conditions
- Infant, Newborn, Immunity, Immunisation, Antibiotic Treatment
- Trial name
- BIP (NCT07189390)
- Testing
- Probiotic
- Where
- 2 sites in Australia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- South Australian Health and Medical Research Institute
Healthy Adult Participants, Gut Microbiomes
DORA - A Study Using Digital Health Tools/Platform to Explore the Impact of the Consumption of Senior Milk Powder Containing Synbiotics on the Gut micRobiome in Healthy Aging Individuals
The DORA study is a single-arm, open-label, interventional exploratory study designed to evaluate the impact of a synbiotic-containing senior milk powder on the gut microbiome and selected biological, physiological, and digital…
- Conditions
- Healthy Adult Participants, Gut Microbiomes, AI
- Trial name
- DORA (NCT07575529)
- Testing
- Synbiotic Nutritional Product
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Healthy
Study on the Enhancement of Intestinal and Immune Functions Through Probiotic Intervention
Evaluate the effectiveness and safety of Bifidobacterium longum subsp. infantis BI45 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.
- Trial name
- NCT06863415
- Testing
- Probiotic
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Exercise Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS)
Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness
The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults.
- Trial name
- NCT07219498
- Testing
- Lactobacillus casei
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Microbiota
Origin of the Neonatal Gut Microbiota and Probiotic Intervention
This study aim to evaluate the composition and origin of the neonatal gut microbiota after birth and Probiotic intervention. Samples were obtained from a total of 30 pregnant individuals and their offspring, divided into control…
- Trial name
- NCT06241222
- Testing
- Probiotic Blend Oral Tablet
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Healthy Adults
Effect of Probiotic Intervention on Travel-Related Health Conditions During Short-Term Overseas Travel
International travel disrupts gut health through dietary changes, microbial exposure, and stress, often causing gastrointestinal symptoms like traveler's diarrhea and sleep disturbances.
- Trial name
- NCT07163819
- Testing
- Probiotic
- Where
- 2 sites in China, Malaysia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Cognitive Decline, Cognitive Change
Dairy Based Probiotic Intervention and Cognitive, Emotional, and Inflammatory Outcomes
The purpose of this study was to determine the effect of dairy-based probiotics on cognitive function, emotional wellbeing, and inflammation.
- Conditions
- Cognitive Decline, Cognitive Change, Inflammation, Emotions
- Trial name
- NCT04643080
- Testing
- Yogurt
- Where
- 4 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Intestinal Permeability
The Effect of Probiotic Intervention on Intestinal Permeability
This trial is a single-site, randomised, double blind, placebo-controlled, two-armed parallel-group trial in healthy adult volunteers.
- Trial name
- NCT03027583
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Healthy Aging, Anti Aging
iVS-1 Probiotic Intervention Targeting Biological Aging in Midlife Adults
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of Bifidobacterium adolescentis (iVS-1) supplementation on biological aging markers, metabolic health, and functional…
- Trial name
- VITAL (NCT07407894)
- Testing
- Bifidobacterium adolescentis iVS-1
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Synbiotic Health
Recurrent Kidney Stones With Colicky Pain
A Clinical Study to Determine the Safety and Efficacy of An Oral Probiotic. Supplementation in Reducing the Risk of Kidney Stone in Adults With Recurrent Kidney Stone Colic or Acute Episode of Colicky Pain.
A Preliminary Investigation of the Safety and Effectiveness of Oral Probiotics Supplementation for Reducing the Risk of Kidney Stone in Adults with Recurrent Kidney Stone Colic or Acute Episode of Colicky Pain: An Open-Label…
- Trial name
- NCT06477471
- Testing
- MetProrenes
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Vaginal Infection
Interventional Study to Evaluate the Effect of the Oral Administration of L.Plantarum on Vaginal Microbiota
Vaginal microbiota is abundantly colonized by Lactobacillus genera. When vaginal microbiota gets altered, opportunistic microorganisms may proliferate and become abundant species giving rise to dysbiosis.
- Trial name
- NCT04461782
- Testing
- Lactobacillus plantarum
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Colonization, Asymptomatic, Probiotic Intervention
Probiotic in Fruit Snack
The aim of this study is to investigate whether a fruit snack containing probiotic ''Lactobacillus rhamnosus'' can survive and establish itself more effectively in the gut when it is protected inside a natural plant-protein…
- Conditions
- Colonization, Asymptomatic, Probiotic Intervention, Gut Microbiota Diversity and Composition, Gut-brain Axis
- Trial name
- Probiotics (NCT07679490)
- Testing
- Microencapsulated Lactobacillus rhamnosus Fruit Snack
- Where
- Ireland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Overweight, Obesity
Effect of Study Probiotics on Body Fat Mass in Overweight and Obese Individuals Following Healthy Lifestyle Intervention
A randomized, double-blind, placebo-controlled, multi-center, parallel group study on overweight and obese individuals following healthy lifestyle consisting of calorie-reduced diet (20% calorie restriction) and increase in daily…
- Trial name
- QLSlimCapHL (NCT03934229)
- Testing
- Daily intake of study product
- Where
- 7 sites in France, Spain
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Danisco France SAS
Aflatoxicosis
Probiotics and Its Associated Factors on Aflatoxin Biomarkers
The study will be aimed to investigate the effect of probiotic intervention and its associated factors on aflatoxin biomarkers among healthy subjects in Serdang and Kajang, Selangor
- Trial name
- NCT03882294
- Testing
- Probiotics
- Where
- Malaysia
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Inflammation
Efficacy of a Probiotic Strain on Level of Markers of Inflammation in an Elderly Population
To investigate the effectiveness of two doses of the probiotic strain Bif-038 on markers of low-grade inflammation in a elderly population
- Trial name
- NCT05529693
- Testing
- Experimental: Bif-038 arm, high dose, Experimental: Bif-038 arm, low dose
- Where
- Ireland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Postpartum Depression
Effect of Consuming a Combination of Probiotic Strains on Postpartum Depression
The objective of this trial is to evaluate the effect of consuming a combination of Lactobacillus during the pregnancy and lactation period on the incidence of postpartum depression.
- Trial name
- NCT06651424
- Testing
- Combination of Lactobacillus probiotics (no comercial)
- Where
- 3 sites in Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Irritable Bowel Syndrome
Vetal Laban Intervention Trial Assessing Bowel Symptoms
A two month intervention trial assessing the effect of Vetal Laban containing L. acidophilus on enhancing functional bowel wellbeing among subjects with irritable bowel syndrome (IBS).
- Trial name
- KF_2013 (NCT01887483)
- Testing
- Vetal Laban active
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Danisco
Elderly Volunteers
Characterization of Fecal Microbiota in a Population Aged 50 to 75 Years Targeted by Seasonal Vaccination
The goal of this interventional study is to constitute a biological samples collection collected from healthy elderly volunteers and used for scientific purposes.
- Trial name
- FIFTY+ (NCT05972590)
- Testing
- Biological samples collection (blood + feces)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bioaster