Clinical trials: Probiotic Therapy
Hypertriglyceridemic Acute Pancreatitis, Acute Pancreatitis, Hypertriglyceridemia-induced
Bacillus Subtilis and Enterococcus Faecium Probiotic Plus Lipid-Lowering Therapy for Hypertriglyceridemic Acute Pancreatitis: A Prospective RCT
Background: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) has become the second most common cause of acute pancreatitis in China, accounting for up to 42.4% of cases, with high recurrence rates and substantial…
- Conditions
- Hypertriglyceridemic Acute Pancreatitis, Acute Pancreatitis, Hypertriglyceridemia-induced, Hyperlipidemia
- Trial name
- NCT07720232
- Testing
- Live Combined Bacillus subtilis and Enterococcus faecium Enteric-coated Capsules (LCBE), Standard Care (in control arm)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Jianyin Zhou
IBS-D (Diarrhea-predominant)
Study to Evaluate the Treatment Benefits of Probiotic Clostridium Butyricum CBM588® for IBS-D
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder affecting 15-20% of people in industrialized countries, often presenting as abdominal discomfort, pain, and altered bowel habits, significantly impacting…
- Trial name
- PROREDI (NCT06676514)
- Testing
- Probiotic Clostridium butyricum CBM588®, Standard of care IBS-D treatment
- Where
- Italy
- Volunteers
- 405 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Halitosis
Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis
Halitosis is a term that defines any odor or bad smell coming from the oral cavity, which can have a local or systemic origin. This project aims to verify if there is a difference in the effectiveness of treatment with…
- Trial name
- NCT06583720
- Testing
- Oral hygiene at home, aPDT, Probiotics
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- University of Nove de Julho
Diarrhea
Effects of Probiotic in Treatment of Persistent Diarrhea in Children
Persistent diarrhea is a common health problem worldwide, particularly in low-income countries. Approximately 3% to 20% of acute diarrhea episodes in children under 5 years of age become persistent diarrhea.
- Trial name
- NCT05812820
- Testing
- LiveSpo DIA30, LiveSpo CLAUSY, RO
- Where
- Vietnam
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Children's Hospital, Vietnam
Bacterial Vaginosis
A Prospective, Randomized Controlled Study of the Probiotics as Adjuvant Treatment for Bacterial Vaginosis
The investigators are trying to determine if oral Probiotics(Umeta-mimi,30 days) with Metronidazole vaginal suppositories (7 days) is better than using Metronidazole vaginal suppositories(7 days) only in preventing the recurrence…
- Trial name
- NCT04771728
- Testing
- Metronidazole vaginal suppositories, Metronidazole vaginal suppositories and Probiotics(Umeta-mimi)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Bacterial Vaginosis
The Impact of Probiotic Bacteria on the Efficacy of Anti-retroviral Therapy and Recurrence of Bacterial Vaginosis
Purpose of the proposed research is to determine the impact of probiotic yogurt supplemented with Lactobacillus rhamnosus (Fiti) compared to regular yogurt on the well-being of women living with HIV.
- Trial name
- NCT01258556
- Testing
- Yogurt supplemented with L. rhamnosus fiti, Yogurt not supplemented with a probiotic strain.
- Where
- Tanzania
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hyperuricemia With or Without Gout
The Effects of a Probiotic Food Supplement in Hyperuricaemia
The overall aim of the project is to determine whether a daily intake of health-promoting bacteria, known as probiotics, with or without a dietary fiber, affects uric acid levels in individuals with elevated levels of uric acid…
- Trial name
- Bugs4U-PoC (NCT07141888)
- Testing
- Probiotics, Probiotics plus fibre
- Where
- Sweden
- Volunteers
- 99 people
- Sponsor
- Örebro University, Sweden
Diarrhea
TEDDY: Spores of Bacillus Clausii in Acute Diarrhoea in Children
Primary objective: To demonstrate the efficacy of a Bacillus clausii probiotic strain compared to placebo in children suffering from acute diarrhoea and treated for 7 days.
- Trial name
- NCT00265369
- Testing
- Spores of Bacillus Clausii Probiotic Strain
- Where
- 2 sites in Belgium, France
- Volunteers
- 420 people
- Sponsor
- Sanofi
Mastitis
Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis
A total of 300 women with lactational infectious mastitis will daily ingest 9 log10 cfu of Lactobacillus salivarius HN6, Lactobacillus reuteri CR20 or Lactobacillus fermentum LC40 for 4 weeks.
- Trial name
- NCT00716183
- Testing
- Lactobacillus salivarius HN6, Lactobacillus reuteri CR20, Lactobacillus fermentum LC40
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Universidad Complutense de Madrid
Periodontitis, Diabetes
Local Delivery of Lactobacillus Reuteri Probiotic as An Adjunct to Non-surgical Periodontal Therapy in Patients With Stage II, III, and IV Periodontitis and Type 2 Diabetes Mellitus
The purpose of the study is to evaluate the effectiveness of local delivery of Lactobacillus reuteri probiotic on periodontitis patients with type 2 diabetes mellitus, as an adjunct to non-surgical periodontal treatment.
- Trial name
- NCT07598656
- Testing
- Lactobacillus reuteri DSM 17938, Distilled water
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Cervical Cancer, Stage IIB
Use of a Fermented Dairy Beverage in Cervical Cancer Patients Undergoing Concurrent Chemoradiation Therapy
Many cancer survivors have increased risk of intestinal damage, affecting the quality of life of patients. The role of intestinal microbiota on the development of gastrointestinal toxicity and radiation enteritis has been…
- Trial name
- NCT05736315
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- National Institute of Cancerología
Obesity &Amp; Overweight
The Impact of Probiotics on Bariatric Treatment Outcomes
The planned study aims to assess whether probiotics improve the quality of life in patients during the early postoperative period following sleeve gastrectomy, and whether they influence the absorption of micro- and…
- Trial name
- PROBE (NCT07258732)
- Testing
- Probiotic, Diet
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Colorectal Cancer Metastatic
Probiotics as Adjuvant Therapy in the Treatment of Metastatic Colorectal Cancer
The research will be prospective, randomised, placebo controlled and double-blinded.The research will be carried on with regards to Helsinki Declaration and following the guidelines of Good Clinical Practice.
- Trial name
- Probat-tmcc-17 (NCT03705442)
- Testing
- Omni-Biotic 10, loperamide ("Seldiar")
- Where
- Croatia
- Volunteers
- 76 people
- Sponsor
- Marin Golčić
Patients on Long-term Proton Pump Inhibitor Therapy
Probiotic Modulation of Intestinal Microbiota in Long-term Intake of Proton Pump Inhibitors
Long-term proton pump inhibitor use has been linked to intestinal dysbiosis, inflammation and gastrointestinal symptoms. Probiotics has been shown to correct dysbiosis, reduce inflammation and strengthen the gut barrier.
- Trial name
- NCT03220802
- Testing
- OMNI-BiOTiC PPI
- Where
- Austria
- Volunteers
- 57 people
- Sponsor
- Medical University of Graz
Spinal Cord Injury, Urinary Tract Infections
Adjuntive Probiotic Therapy in Treating Urinary Tract Infections in Spinal Cord Injury
We hypothesize that probiotic Lactobacillus can augment antibiotic treatment of symptomatic urinary tract infection (UTI) in spinal cord injured patients, and also increase the time to the next episode of UTI.
- Trial name
- NCT00594594
- Testing
- Probiotic Lactobacillus GR-1 and RC-14
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Human Immunodeficiency Virus
Improving Prognosis in HIV Infection
The primary objective of this study is to assess the safety of probiotics in cART-treated immunologic non-responder (INR) patients with chronic HIV infection.
- Trial name
- NCT02640625
- Testing
- Probiotic compound
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Atopic Dermatitis
Clinical Trial to Evaluate the Effect of a Probiotic Mixture in the Treatment of Atopic Dermatitis in Children
A prospective case-control multicentric pilot study of 12 weeks duration to evaluate the effect of a probiotic mixture in the treatment of atopic dermatitis in children from 0 to 3 years old, by measuring the severity of the…
- Trial name
- NCT05443490
- Testing
- Probiotic mixture with three bacterial strains with maltodextrin as a carrier.
- Where
- 3 sites in Bolivia, Costa Rica and 1 more
- Volunteers
- 4 people
- Sponsor
- Bionou Research, S.L.
Epilepsy, Treatment
Probiotic in Treatment of Adult Patients With Drug-resistant Epilepsy
This study is a randomized, double-blind parallel group placebo-controlled clinical trial with the aim of investigating the effect of probiotic versus placebo on drug-resistant adult patients with epilepsy.
- Trial name
- NCT05160350
- Testing
- Probiotic
- Where
- Iran
- Volunteers
- 42 people
- Sponsor
- Mazandaran University of Medical Sciences
Menopause
Menopausal Symptoms Probiotic Study
In this study, we want to investigate if the active product consisting of a probiotic blend can potentiate the recirculation of active oestrogens into the bloodstream and help to mitigate menopause symptoms, which are closely…
- Trial name
- NCT06446869
- Testing
- Gyntima Menopause
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Community Pharmacology Services Ltd
Atopic Dermatitis
Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children
Atopic dermatitis (AD) is an immune disorder, characterized by chronic skin inflammation or relapsing, whose prevalence is increasing worldwide. Its exact etiology remains unknown.
- Trial name
- NCT02519556
- Testing
- Probiatop
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Casa Espirita Terra de Ismael