Clinical trials: Probiotic Therapy
Rectal Cancer
VSL#3 Versus Placebo in Increasing the Pathological Major Response Rate in Patients With Rectal Cancer
This is a randomized, double-blind, placebo-controlled phase III study involving 160 patients designed to assess the efficacy of the high potency probiotic preparation VSL#3® versus placebo in increasing the pathological major…
- Trial name
- NCT01579591
- Testing
- VSL#3
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Catholic University of the Sacred Heart
Atopic Dermatitis
A Clinical Trial Evaluating a Probiotic Emollient for the Treatment of Pediatric Atopic Dermatitis
The goal of this study is to evaluate the efficacy of the emollient topical formulation containing Lactobacillus reuteri in improving atopic dermatitis symptoms in children.
- Trial name
- NCT07072273
- Testing
- Probiotic Ointment
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Biogaia New Sciences AB
Gingivitis, Periodontal Inflammation
Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients
Orthodontic treatment with fixed appliances can be necessary to correct malocclusions in adolescence or adulthood. It its known that orthodontic treatment induces aseptic pseudo-inflammatory reactions.
- Conditions
- Gingivitis, Periodontal Inflammation, Orthodontic Appliance Complication
- Trial name
- NCT04606186
- Testing
- Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg
Crying
Lactobacillus Reuteri Versus Herbal Drop in the Treatment of Infantile Colic: a Prospective Study
The aim was to test the hypothesis that oral administration of Lactobacillus reuteri in a prospective randomized controlled study would improve symptoms of infantile colic.
- Trial name
- NCT01855269
- Testing
- Lactobacillus reuteri, Herbal drop
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Ulcerative Colitis
Interest of Propionibacterium Freudenreichii for the Treatment of Mild to Moderate Ulcerative Colitis
Ulcerative colitis (UC) is an immune mediated chronic inflammatory bowel disease that results at least in part of an abnormal immune response to environmental factors including the intestinal microbiota.
- Trial name
- EMMENTAL (NCT02488954)
- Testing
- Probiotics in the form of cheese portion
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Rennes University Hospital
Radiation Proctitis, Probiotics
The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis
Radiation proctitis is a common complication after radiation therapy for pelvic tumors. The investigators found that live bifidobacterium and lactobacillus tablets combined with compound glutamine enteric-coated capsules can…
- Conditions
- Radiation Proctitis, Probiotics, Glutamine, Gut Microbiota
- Trial name
- NCT05406882
- Testing
- Live Combined Bifidobacterium and Lactobacillus Tablets、Compound Glutamine Entersoluble capsules
- Where
- 2 sites in China
- Volunteers
- 176 people
- Sponsor
- West China Hospital
Colorectal Cancer
Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy Among Colorectal Cancer Patients
Colorectal cancer (CRC) is one of the most common types of cancer worldwide in general and in Jordan in specific. The studies that investigate the role of Probiotics supplementation in improving the inflammatory response…
- Trial name
- NCT03742596
- Testing
- Probiotic Formula Capsule, Control
- Where
- Jordan
- Sponsor
- King Hussein Cancer Center
Acute Watery Diarrhea
Comparison of WHO Treatment of Acute Watery Diarrhea With or Without Probiotic (Bacillus Clausii) in Children
This study aimed to compare WHO treatment of acute watery diarrhea with or without probiotic (bacillus clausii) in term of mean duration of diarrhea in children
- Trial name
- NCT06887374
- Testing
- Probiotic Bacillus Clausii
- Where
- Pakistan
- Volunteers
- 184 people
- Sponsor
- Muhammad Aamir Latif
Helicobacter Pylori Infection
A Clinical Trial on the Efficacy of Gastric Probiotics in the Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess the safety and efficacy of Lactobacillus plantarum, Bacillus coagulans and Lactobacillus plantarum + Bacillus coagulans for eradication of Helicobacter Pylori, as well as the efficacy of…
- Trial name
- NCT05483660
- Testing
- Lactobacillus plantarum, Bacillus coagulans, Lactobacillus plantarum + Bacillus coagulans
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Pneumonia, Pneumonia in Children
Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia
The main questions this study aims to answer are: Does using probiotic nasal spray (LiveSpo Navax containing Bacillus subtilis and Bacillus clausii, 1x10^9 CFU/mL), with or without oral probiotics (LiveSpo Pregmom containing…
- Trial name
- NCT07399717
- Testing
- Navax, Navax-PregMom
- Where
- Vietnam
- Volunteers
- 330 people
- Sponsor
- Anabio R&D
Upper Respiratory Tract Infections, Pharyngitis
Efficacy and Safety of L. Plantarum and P. Acidilactici in Children With Upper Respiratory Tract Infections
Randomized, placebo-controlled trial to evaluate the coadjuvant effect of a combination of L. plantarum and P. acidilactici probiotic strains, taken twice daily, in children 6 months to 5 years-old with upper respiratory tract…
- Conditions
- Upper Respiratory Tract Infections, Pharyngitis, Tonsillitis
- Trial name
- NCT05279534
- Testing
- Probiotic
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- AB Biotics, SA
Ulcerative Colitis, Irritable Bowel Syndrome
Efficacy of Probiotics in Patients With IBD
This research group plans to take patients with mild to moderate UC and diarrhea IBS diagnosed in the First Affiliated Hospital of Xinxiang Medical College as examples, and divide them into UC group and IBS group; Each group was…
- Trial name
- NCT05652621
- Testing
- probiotics
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Hypothyroidism
Interaction Between Levothyroxine and Probiotics in Hypothyroid Patients
A prospective, randomized, single-blind, controlled, investigator-started clinical trial was carried out. Patients with primary hypothyroidism were randomly assigned to the study (VSL#3®+ LT4) and the control group (LT4).
- Trial name
- NCT03095963
- Testing
- a mixture of highly charged Lactobacilli and Bifidobacteria (VSL#3®), levothyroxin
- Volunteers
- 80 people
- Sponsor
- Azienda USL Modena
Gastroenteritis, Diarrhea
The Treatment Effect of Bio-Three on Children With Enteritis
Diarrhea due to acute enteritis is a common symptom in the children. Lots of patients are infected by rotavirus or salmonella. Base on the past researches, there is benefit effect of probiotics on patients with diarrhea or acute…
- Trial name
- Bio-three (NCT01480947)
- Testing
- Bio-three
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Irritable Bowel Syndrome
Probiotics for Irritable Bowel Syndrome
The study aims to investigate the effect of probiotics on IBS-patients symptoms compared to placebo, when given for 6 months. By draw the investigators give IBS patients, in the age of 18-50 years, capsules with either probiotics…
- Trial name
- NCT01151657
- Testing
- Probiotics
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Healing
Effect of Probiotics After Neurosurgery
The goal of this randomised controlled trial is to determine the effect of consuming a multistrain probiotic OMNi-BiOTiC® Hetox on improving the healing, pain management, and postsurgical complications after neurosurgery.
- Trial name
- ProSURG (NCT07200518)
- Testing
- OMNi-BiOTiC® Hetox multistrain probiotic
- Where
- Slovenia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University Maribor
Unexplained Infertility, Endometriosis
Probiotic and Antibiotic Therapies in Women With Unexplained Infertility
The study is designed as a proof of concept pilot study with 3 study arms to evaluate the safety and feasibility of the use of oral probiotics and/or antibiotics in women with unexplained infertility/endometriosis.
- Trial name
- NCT04955574
- Testing
- SH-DS01 + Metronidazole
- Sponsor
- McMaster University
Familial Mediterranean Fever (FMF )
The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.
Colchicine is the drug of choice to treat patients with Familial Mediterranean Fever (FMF ), some of the patients treated with colchicine may suffer from gastrointestinal (GIT) adverse effect such as diarrhea and abdominal pain…
- Trial name
- NCT02021084
- Testing
- probiotic
- Sponsor
- Rambam Health Care Campus
Periodontitis
Systemic Probiotics in the Periodontal Treatment
The aim of this multicenter randomized clinical trial is to evaluate the clinical, microbiological and immunological effects of probiotics as an adjunct to Scaling and Root Planing alone or in combination with Metronidazole and…
- Trial name
- NCT03733379
- Testing
- Scaling and root planing, Metronidazole, Amoxicillin
- Where
- 2 sites in Brazil
- Volunteers
- 176 people
- Sponsor
- Belén Retamal-Valdes
Histamin Intolerance
Treatment of Histamine Intolerance Using Probiotic Intervention
The goal of this clinical trial is to learn if a probiotic product can lower symptoms in adults with histamine intolerance. Histamine intolerance can cause stomach and bowel problems as well as symptoms such as flushing, itching…
- Trial name
- NCT07397962
- Testing
- Probio Histamed®, a multi-species probiotic preparation containing Bifid. breve, Bifid. lactis, Bifid. infantis, Bifid. longum, Lact. gasseri, and Lact. rhamnosus (5 x 10⁹ CFU per day)
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- University of Hohenheim