Clinical trials: Probiotics, Periodontitis
Periodontitis Stage IV, Periodontitis
Microbiological Modulation Of The Oral-Gut Axis After Treatment With Or Without Systemic Use Of Probiotics In Patients With Periodontitis: A Randomized Controlled Clinical Study.
This study aims to evaluate whether the oral administration of probiotics, in combination with conventional periodontal treatment (deep cleaning of the tooth root surfaces), can improve oral health and influence the relationship…
- Trial name
- NCT07792902
- Testing
- Probiotics Bifidobacterium animalis subsp. lactis HN019
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Periodontitis
Efficacy of a Probiotic Lozenges in Chronic Periodontitis Patients.
Periodontal disease is an infectious disease resulting in inflammation within supporting tissues of the teeth, progressive attachment loss, and bone loss.
- Trial name
- NCT02121665
- Testing
- Probiotic (Inersan)
- Where
- India
- Volunteers
- 42 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Diabetes Mellitus,Type 2, Periodontitis
Effects of a Probiotic on Oral Microbiota and Glycemic Control in Type 2 Diabetics; A Randomized Clinical Trial
The present study evaluated clinically the effects of a probiotic on oral microbiota and glycemic control in T2 diabetic patients with periodontal disease.
- Trial name
- NCT04913909
- Volunteers
- 70 people
- Sponsor
- Istanbul University
Mild and Moderate Chronic Periodontitis
Effect of Probiotic Lozenge on Gingivitis and Periodontitis
The oral cavity is mostly influenced by general health. The oral microbiota which is as complex as the gastro-intestinal or vaginal microbiota are considered to be difficult therapeutic targets.
- Trial name
- NCT02203812
- Testing
- Probiotic Arm
- Where
- India
- Volunteers
- 32 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Chronic Periodontitis Complex
Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.
Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics.
- Trial name
- NCT03692819
- Testing
- Amoxicillin 500 Mg, Lactobacillus reuteri Oral Drops
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Healthy Adult Participants, Periodontal Disease
Clinical, Microbiological and Immunological Effects of the Adjuvant Use of Systemic Antibiotics and Probiotics in the Non-surgical Treatment of Periodontitis
Although robust evidence supports the benefits of antibiotics in periodontal treatment, the potential adverse effects of this therapy cannot be overlooked.
- Trial name
- NCT07592416
- Testing
- Amoxicilin and Metronidazole, Probiotic Therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis
The Use of a Probiotic Lozenge in the Treatment of Residual Pockets After Classical Non-surgical Therapy
The aim of this study is to determine the efficacy of the usage of a probiobitc lozenge in patients with residual bleeding pockets of ≥ 5mm 3 months following scaling and rootplaning.
- Trial name
- NCT02490618
- Testing
- Probiotic tablet- Biogaia
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Halitosis
Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis
The purpose of this study is to determine whether Lactobacillus reuteri-containing lozenges (Prodentis) are effective in treatment of halitosis in patients with chronic periodontitis.
- Trial name
- NCT02789436
- Testing
- L. reuteri Prodentis® lozenges
- Where
- Croatia
- Volunteers
- 30 people
- Sponsor
- University of Zagreb
Periodontitis
Probiotics as Adjunct to Nonsurgical Periodontal Treatment
ProlacSan probiotic lozenges and gels contain L. plantarum and L. brevis strains with proven in vitro antimicrobial activity against P. gingivalis.
- Trial name
- NCT04137419
- Testing
- Probiotic lozenges
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University of Ljubljana
Diabetes, Periodontitis
Non Surgical Therapy of Periodontitis in Diabetes Patients: the Adjunctive Use of Probiotics
The aim of this study is to evaluate the clinical and microbiological performance of a probiotic formulation (Sunstar GUM Periobalance) as adjunctive to non-surgical periodontal therapy in patients with diabetes.
- Trial name
- ProDiabet (NCT04069611)
- Testing
- Probiotic, Scaling and root planing
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Periodontitis Stage III, Probiotic
Evaluation Of The Effect Of Streptococcus Salivarius K12 Probiotic In The Treatment Of Periodontitis
Aims: The use of oral probiotics as an adjunct to the treatment of periodontal diseases is known to be beneficial in antagonizing pathogenic microflora and regulating the host immune response.
- Trial name
- NCT06871540
- Testing
- Probiotic Agent, Non-Surgical Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AYŞENUR ŞAHİN
Periodontitis, Probiotics
Effects of Probiotic Therapy in the Treatment of Periodontitis.
The aim of this study is to evaluate the effect of the probiotic therapy as an adjunct to non-surgical periodontal treatment in patients diagnosed with Generalized Chronic Periodontitis.
- Trial name
- NCT03408548
- Testing
- Scaling root planning, Probiotic
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Sao Paulo
Dental Caries, Periodontitis
Salivary IgA and Cytokines Response to Dietary Supplementation of Lactobacillus Reuteri
To evaluate the effect of daily ingestion of the probiotic Lactobacillus reuteri on the levels of secretory IgA and the cytokines Il1-beta, IL-6, IL-8 and IL-10 in saliva of healthy young adults.
- Trial name
- NCT02017886
- Testing
- L. reuteri DSM 17938/ATCC PTA
- Where
- Denmark
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
-Chronic Periodontitis
Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis
The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of Lactobacillus rhamnosus SP1- containing probiotic tablets as an adjunct to scaling and root planning (SRP).
- Trial name
- probiotic (NCT02283736)
- Testing
- Lactobacillus rhamnosus SP1, Talc powder, Periodontal treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Jorge Gamonal
Periodontitis, Probiotic
Patient-Reported Probiotic Use During Periodontal Therapy in Periodontitis
Most previous studies have evaluated standardized probiotic regimens as adjuncts to NSPT (Ausenda et al., 2023; Hardan et al., 2022; Mauriello et al., 2025).
- Conditions
- Periodontitis, Probiotic, Oral Hygiene, Oral Health, Periodontal Therapy
- Trial name
- NCT07619040
- Testing
- non surgical periodontal therapy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Medipol University
Chronic Periodontitis
Efficacy of a Probiotic Lozenge (Inersan) in Patients With Chronic Periodontitis
Periodontal disease is a major cause of tooth loss in humans and is one of the most prevalent diseases associated with bone loss.
- Trial name
- NCT01870362
- Testing
- Probiotic (Inersan)
- Where
- India
- Volunteers
- 28 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Chronic Periodontitis
Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers
Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species.
- Trial name
- NCT02329353
- Testing
- Lactobacillus brevis CD2 Lozenges
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Next Gen Pharma India Pvt. Ltd.
Chronic Periodontitis
Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection
The purpose of this study is to evaluate beneficial effects of probiotic Lactobacillus brevis CD2 tablets in addition to the primary treatment for patients with chronic periodontitis (Full Mouth Disinfection), at local level and…
- Trial name
- NCT01438333
- Testing
- lactobacillus brevis tablets
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of L'Aquila
Chronic Periodontitis
Evaluation of the Efficacy of Probiotics in Chronic Periodontitis Patients
Periodontitis is an infectious inflammatory disease. Bacteria modulate the inflammatory response and alter the diversity of periodontal disease.
- Trial name
- NCT02390687
- Testing
- Probiotic
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Next Gen Pharma India Pvt. Ltd.