Clinical trials: Procalcitonin
Influenza
Procalcitonin Role in Influenza Patients With Regard to Morbidity, Mortality and Antibiotic Use
The investigators intend to observe the inflammatory marker procalcitonin (PCT) in comparison with patient variables on morbidity, mortality and antibiotic treatment.
- Trial name
- NCT04171128
- Testing
- antibiotic stewardship efforts
- Where
- 2 sites in Norway
- Volunteers
- 119 people
- Sponsor
- Ostfold Hospital Trust
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Pneumonia, Pediatric Respiratory Diseases
Procalcitonin to Reduce Antibiotic Use in Pediatric Pneumonia
This pilot study will evaluate study processes and feasibility of a future large-scale clinical trial that proposes to test whether low-risk children managed as outpatients with community-acquired pneumonia (CAP) and…
- Conditions
- Pneumonia, Pediatric Respiratory Diseases, Antibiotic Use, Community-acquired Pneumonia
- Trial name
- PRAPP (NCT04963764)
- Testing
- Amoxicillin
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Non-cystic Fibrosis Bronchiectasis
Procalcitonin as a Marker of Severity of Non-cystic Fibrosis Bronchiectasis in Children
The aim of this study is to evaluate the role of procalcitonin in bronchoalveolar lavage as a biomarker for assessment of severity of non-CF bronchiectasis in children in correlation with other markers (functional and…
- Trial name
- NCT06352944
- Testing
- procalcitonin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Acute Kidney Injury
Serum Procalcitonin Level May Predict Acute Kidney Injury in ICU Patients With Sepsis
The aim of this study is to examine if procalcitonin (PCT) can be used for early prediction of AKI septic patients in ICU.
- Trial name
- NCT03097393
- Testing
- measure Serum procalcitonin level
- Volunteers
- 67 people
- Sponsor
- Benha University
Sepsis, Intensive Care
Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU
The adequacy of early empiric antimicrobial therapy is an important factor in determining the outcome in patients with severe sepsis. The duration of adequate antibiotic therapy in these patients however is less clear.
- Trial name
- NCT00987818
- Testing
- Procalcitonin measurement
- Where
- Netherlands
- Sponsor
- Rijnstate Hospital
Respiratory Tract Infections, Urinary Tract Infections
HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study
This study will analyze gene expression data (HostDx Sepsis test) from blood samples collected from participants with suspected infections.
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Skin and Soft Tissue Infections, Intraabdominal Infections
- Trial name
- NCT03744741
- Testing
- HostDx Sepsis
- Where
- 7 sites in United States, Greece
- Volunteers
- 585 people
- Sponsor
- Inflammatix
Neutrophils to Lymphocytes, Platelets
Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.
This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.
- Conditions
- Neutrophils to Lymphocytes, Platelets, Procalcitonin, Total Leucocytic Count
- Trial name
- NCT07200817
- Testing
- Neutrophils to Lymphocytes and Platelets ratio (N/LP)
- Where
- Egypt
- Volunteers
- 290 people
- Sponsor
- Ain Shams University
Cirrhosis, Ascites
Procalcitonin in Cirrhotic Patients at High Risk for Sepsis
Infections are frequent life-threatening events in patients with cirrhosis, occurring at least in 35% of hospitalized patients and accounting for 20% of inpatients death.
- Conditions
- Cirrhosis, Ascites, Sepsis
- Trial name
- NCT01578226
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Prof. Facchinetti Fabio
Ovarian Neoplasms Malignant, Anastomotic Leak
Early Dehiscence Markers in Ovarian Cancer Surgery
EDMOCS trial pretends to evaluate if C-reactive protein (CRP) and procalcitonin (PCT) can predict intestinal anastomotic leaks before early discharge in advanced ovarian cancer surgery requiring intestinal resection.
- Trial name
- EDMOCS (NCT03131492)
- Testing
- Blood test
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
COPD Exacerbation Acute
CRP, Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD
Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) are one of the chief causes for admission to Emergency Department. AECOPD is a significant cause for mortality and morbidity worldwide.
- Trial name
- AECOPD (NCT06514599)
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pyelonephritis
Kinetics of Biomarkers in Acute Pyelonephritis
The objective of this study is to explore the kinetics of biomarkers in 30 adult female patients with uncomplicated acute pyelonephritis.
- Trial name
- NCT00805181
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Pneumonia, Bacterial
Diagnostic Accuracy of Infection Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia
The aim of this study is to investigate the diagnostic and prognostic value of C-reactive protein (CRP), serum procalcitonin (PCT) and soluble urokinase plasminogen activator receptor (suPAR) in the initial investigation of…
- Trial name
- NCT04652167
- Testing
- PCT, suPAR, Standard care
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
Pregnancy, Premature Delivery
Procalcitonin and Threatened Premature Delivery
Among all patients hospitalized for Threatened Premature Delivery (TPD), the rate of premature birth (PB) before 37 weeks is about 42%, which reflects the inability to accurately identify patients at high risk of PB.
- Trial name
- MAPPRO (NCT01977079)
- Testing
- procalcitonin
- Where
- France
- Volunteers
- 131 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Pancreatic Cancer
Procalcitonin Reveals Early Dehiscence in Pancreatic Surgery: the PREDIPS Study
Background. Pancreatic cancer surgery is associated with very high risk of postoperative morbidity and mortality. Anastomotic leak (AL) is one of the worst complications associated with relevant short and long-term sequelae.
- Trial name
- PREDIPS (NCT02756468)
- Testing
- pts operated for pancreatic cancer
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Community Acquired Pneumonia
Biomarker Guided Antibiotic Treatment in Community-Acquired Pneumonia
The purpose of this study is to determine the efficacy of C-reactive protein and procalcitonin based guidelines versus standard of care to reduce duration of antibiotic exposure in patients hospitalized with community acquired…
- Trial name
- BIO-CAP (NCT03146182)
- Testing
- CRP-algorithm, PCT-algorithm
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Gertrud Baunbaek Egelund
Sepsis, Fever
Procalcitonin in Diagnosing Bacteremia in the Emergency Department
Nowadays, a physician plays a more important role in managing patients with potential infectious complications in the emergency room.
- Trial name
- NCT00174122
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Secondary Peritonitis After Intestinal Perforation
Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis
Procalcitonin (PCT) serum levels are monitored in patients with secondary peritonitis after initial operative focus elimination to investigate the PCT ratio's impact on decision-making for or against early relaparotomy in the…
- Trial name
- NCT01768936
- Where
- Germany
- Volunteers
- 234 people
- Sponsor
- CHIR-Net
Coronary Disease
Pro-calcitonin Marker as Indicator of Ischemia in Patients With Complicated Coronary Intervention.
The aim of this study is to determine on preliminary basis weather an elevated pro-calcitonin level can be used to assess ischemia as a result of coronary artery complications during percutaneous coronary intervention (PCI).
- Trial name
- NCT01609569
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Saint Michael's Medical Center
Respiratory Tract Infections, Pneumonia, Bacterial
Procalcitonin in Early Antibiotic Interruption in Patient With Bacterial Pulmonary infeCtion and Acute Heart Failure
Introduction: Acute Heart Failure is frequently decompensated by pulmonary infection, but the diagnosis of pulmonary infection sometimes is difficult in these patients due to similar signals and clinical symptoms in both…
- Conditions
- Respiratory Tract Infections, Pneumonia, Bacterial, Heart Failure
- Trial name
- EPICAD (NCT02787603)
- Testing
- Interruption of antibiotic treatment due to PCT measurement
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital