Clinical trials: Procalcitonin, active
Acute Exacerbation of COPD
Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial
COPD is a common chronic disease. Its natural course is characterized by Acute exacerbations (AE). This may require hospitalization or even ICU/RESUSCITATION admission.
- Trial name
- MULTI-EXA (NCT05280132)
- Testing
- Personalized antibiotic treatment, Usual antibiotic treatment
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Procalcitonin, Infection
Procalcitonin as a Prognostic Predictor in Patients With Acute Infectious Disease Hospitalized in the Internal Medicine Department.
Procalcitonin is a well-known biomarker used to distinguish between bacterial and viral infections, assess a patient's risk category, and serve as a prognostic indicator.
- Conditions
- Procalcitonin, Infection, Internal Medicine Patients
- Trial name
- NCT07770334
- Testing
- No Interventions
- Volunteers
- 1,000 people
- Sponsor
- Barzilai Medical Center
Sepsis
Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)
MODIFY is a randomized, open-labeled, and prospective study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- MODIFY (NCT05909683)
- Testing
- Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results., Standard of Care
- Where
- 15 sites in Greece
- Volunteers
- 190 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Sepsis - to Reduce Mortality in the Intensive Care Unit, Burns Involving 20% or More of Body Surface
Evaluating the Accuracy of Multiple Blood Tests to Diagnose Sepsis in Adult Burn Patients
This prospective diagnostic accuracy study evaluates the performance of presepsin and C-reactive protein (CRP) as early biomarkers for suspected sepsis in adult burn patients.
- Trial name
- BioBurnSepsis (NCT07126574)
- Where
- South Korea
- Volunteers
- 165 people
- Sponsor
- Dohern Kym
Acute Respiratory Infection
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
This study will evaluate whether an expanded diagnostic strategy can reduce antibiotic use in patients aged 65 years or older who are hospitalized with community-acquired acute respiratory infection, without negatively affecting…
- Trial name
- NeuBluMul (NCT07883902)
- Testing
- Expanded Diagnostic Strategy, Conventional Diagnostic Strategy
- Where
- Spain
- Volunteers
- 406 people
- Sponsor
- Santiago Lopez Gil
Sepsis, Osteoporotic Hip Fracture
Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)
Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death.
- Conditions
- Sepsis, Osteoporotic Hip Fracture, Hip Fracture
- Trial name
- MDW (NCT07350785)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Sepsis, Severe
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis
To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the improvement or deterioration of sepsis.
- Trial name
- BIS6 (NCT03244293)
- Testing
- no intervention
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Aided Antimicrobial Therapy vs Standard of Care
Antibiotic resistance is driven by overuse, especially for viral respiratory infections. Procalcitonin (PCT), a biomarker for bacterial infections, helps guide antibiotic therapy more precisely, reducing unnecessary use and…
- Trial name
- PCT (NCT06960044)
- Testing
- Procalcitonin-guided antibiotic management, Standard of care
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Sepsis, Septic Shock
Renin Levels as Prognostic Indicators of Septic Shock Severity and Outcome
The Surviving Sepsis Campaign (SSC) of 2021 characterizes sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection, with a mortality rate of over 30%, which increases to 40% or more in…
- Trial name
- NCT06545838
- Testing
- Analysis of plasma renin concentration
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Sepsis
Dynamic Infection Kinetics for Early Diagnosis, Monitoring, and Prognostication of Sepsis in Adult Oncology Patients: Evaluating Serial Infection Biomarkers, Blood Culture Kinetics, Treatment Response, Disease Severity, and Clinical Outcomes
Dynamic Infection Kinetics as an Early Diagnostic and Monitoring Tool for Sepsis in Oncology Patients This study aims to evaluate whether changes over time in infection-related biomarkers and blood culture findings can help…
- Trial name
- NCT07795502
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Colorectal (Colon or Rectal) Cancer, STOMACH NEOPLASM
Perioperative Biomarkers in Colorectal and Gastric Cancer Surgery
This study aims to evaluate whether monitoring perioperative inflammatory and metabolic biomarkers can help identify postoperative complications early in adult patients undergoing colorectal or gastric cancer surgery.
- Trial name
- PERIO-BIO (NCT07881133)
- Testing
- Perioperative Biomarker-Guided Monitoring
- Where
- Romania
- Volunteers
- 320 people
- Sponsor
- Bucharest Emergency Hospital
Community-Acquired Pneumonia (CAP), Pneumonia
Clinical Impact of Rapid Molecular Testing for Pathogens in Patients With Severe Acute Respiratory Illness : A Pragmatic Trial
Community-acquired pneumonia (CAP) is among the most common reasons for emergency department (ED) visits. A clear understanding of the likely pathogens is essential for the rapid institution of adequate antimicrobial therapy.
- Trial name
- CIRT-RMT-SARI (NCT06605352)
- Testing
- The BIOFIRE®FILMARRAY® Pneumonia Panel
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Taiwan University Clinical Trial Center
Septic Shock
The Relation Between Triglyceride- Glucose Index, Procalcitonin and Cardiac Affection in Septic Shock.
The study is carried out to demonstrate the relation between Triglyceride -glucose index and cardiac affection in the patients admitted to the ICU with septic shock.
- Trial name
- NCT06518083
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ventilator Acquired Pneumonia
Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU Patients
Ventilator-associated pneumonia (VAP) is a common and serious infection among mechanically ventilated ICU patients. Early diagnosis remains challenging because clinical and radiological findings may lack specificity.
- Trial name
- PROZINC-VAP (NCT07696897)
- Testing
- Serum Procalcitonin Measurement, Serum Zinc Measurement
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Bacterial Infections
Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy
In this randomized controlled open-label trial, conducted in 7 French Pediatric and Neonatal Intensive Care Units (ICUs), investigator team hypothesize that the use of a procalcitonin (PCT)-guided algorithm to discontinue…
- Trial name
- PRODISCO (NCT05350813)
- Testing
- Measurement of the PCT plasma levels, Usual practice based on guidelines
- Where
- 8 sites in France
- Volunteers
- 296 people
- Sponsor
- University Hospital, Toulouse
Infection, Sepsis
KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Use in Critically Ill Patients
The study aims to compare the efficacy and safety of an absolute procalcitonin (PCT) value-guided antibiotic initiation protocol and a protocol using the kinetics of PCT (the difference between the actual and the previous day…
- Trial name
- KIPRUN (NCT07211620)
- Testing
- Kinetics, Absolute
- Where
- 2 sites in Hungary
- Volunteers
- 250 people
- Sponsor
- Semmelweis University
Community Acquired Pneumonia (CAP), Hospital Acquired Pneumonia
Pneumonia Pathogens' Virulence Factors, Patient Inflammatory Markers, and Their Associations With Outcomes
The study aims to evaluate pneumonia symptoms using physical examinations, radiological and laboratory tests, and prognostic scales such as the Pneumonia Severity Index (PSI) and CURB65.
- Trial name
- Pneumonia-1 (NCT07011433)
- Testing
- Inflammatory Biomarker Evaluation
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Ruta Nutautiene
Burns, Sepsis
Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU Patients
The investigators will compare the efficacy of Interleukin-6 (IL-6) as a better indicator than procalcitonin in burn patients with sepsis or septic shock regarding success of treatment and early ICU discharge.
- Conditions
- Burns, Sepsis, Septic Shock, Death
- Trial name
- NCT06915974
- Testing
- Interleukin 6
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Pneumonia, Critical Illness
Respiratory Physiotherapy and Inflammatory Biomarkers in Critically Ill Patients With Pneumonia
The goal of this observational study is to evaluate the safety and impact of a protocolized respiratory physiotherapy program on the dynamics of systemic inflammatory biomarkers (procalcitonin [PCT] and C-reactive protein [CRP])…
- Trial name
- NCT07909616
- Testing
- Protocolized Respiratory Physiotherapy Program
- Where
- Mexico
- Volunteers
- 180 people
- Sponsor
- Hospital H+ Queretaro
Sepsis, Critical Illness
SOFA Score with Serum Procalcitonin Versus SOFA Score with Neutrophil/lymphocyte Ratio in Predicting Sepsis and Clinical Outcomes in I.C.U.
Sepsis remains a critical life-threatening and a healthcare challenge worldwide. Sepsis is implicated in a mortality rate that ranges between 25 - 30% in severe cases and 40-70% in septic shock, also, Post sepsis, lower quality…
- Trial name
- SOFA-PROVSNL (NCT06847477)
- Volunteers
- 40 people
- Sponsor
- Ain Shams University