Clinical trials: Processes, Metabolic
Environmental Enteric Dysfunction
OCT Guided Trans Nasal Imaging of the Small Intestine in Adults
The investigators are seeking healthy adult participants 18-60 years and healthy pregnant women in their 2nd trimester of pregnancy for a research study to assess a new imaging device.
- Trial name
- NCT04984447
- Testing
- TNIB Catheter
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
CKD, ESRD
Effect of Oxalate and Urate Metabolism on CKD Evolution
The current study primarily aimed to characterize the oxalate and uric acid metabolism in CKD patients and to analyze its association with renal survival prognosis.
- Conditions
- CKD, ESRD, Hyperuricemia, Oxaluria
- Trial name
- NCT04399915
- Where
- Ukraine
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The Institute of Nephrology of the Academy of Medical Sciences of Ukraine
Developmental Disability, Chronic Disease
QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease
The aim of this cross-sectional study is to investigate the level of stress and quality of life in parents of children with developmental disabilities (Down syndrome, autism spectrum disorder, pervasive developmental disorder…
- Conditions
- Developmental Disability, Chronic Disease, Down Syndrome, Autism Spectrum Disorder
- Trial name
- NCT03602378
- Testing
- salivary cortisol, Holter Medilog AR12 Plus, Polar V800
- Where
- 2 sites in Croatia
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Hypertension, Type 2 Diabetes Mellitus
Nanshan Elderly Cohort Study
Objective: The Nanshan Elderly Cohort Study (NECS) aims to investigate the nutritional, as well as other environmental and genetic factors of chronic diseases, such as cardio-metabolic diseases.
- Conditions
- Hypertension, Type 2 Diabetes Mellitus, Cardiovascular Diseases, Stroke
- Trial name
- NECS (NCT03569735)
- Where
- 2 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cystic Fibrosis
Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis
OBJECTIVES: I. Compare the clinical status of pregnant vs non-pregnant women with cystic fibrosis. II. Determine glucose tolerance during each trimester of pregnancy in these women. III.
- Trial name
- NCT00014768
- Testing
- glucose, insulin, leucine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Diabetes Mellitus, Arrhythmias, Cardiac
Tolerance of Centrifuge-induced Acceleration in Subjects With Diabetes Mellitus and Cardiac Arrhythmia
The study will involve exposing individuals with a known past medical history of diabetes mellitus and/or cardiac arrhythmias to centrifuge-induced acceleration force (G-force) in the NASTAR AFTS-400 simulator to evaluate their…
- Trial name
- NCT05404789
- Testing
- Centrifugation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Celiac Disease
ICT Tools for the Diagnosis of Autoimmune Diseases
The ITAMA project, which ended in 03/2022, came from the need to increase/anticipate the number of diagnosed cases of celiac disease (CD).
- Trial name
- ITAMA_CAP (NCT05715970)
- Testing
- PoCT+questionnaire administration
- Where
- 2 sites in Italy, Malta
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Obesity, Childhood, Cognition
NiPPeR Randomised Trial - Child Follow Up Study
There is an increasing focus on the need to optimise nutrition, lifestyle and metabolism of parents before and during pregnancy and of the infant after birth, but as yet there is limited understanding of the specific influences…
- Conditions
- Obesity, Childhood, Cognition, Neurobehavioral Manifestations, Metabolic Disturbance
- Trial name
- NiPPeR Child (NCT05934422)
- Testing
- Intervention (Study Nutritional Drink), Control (Standard Nutritional Drink)
- Where
- 3 sites in New Zealand, Singapore and 1 more
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Weight Loss, Anovulation
Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
The objective of this study is to explore the effects of weight loss on body composition, metabolic status, reproductive hormones, and ovarian follicle development in obese women with regular menstrual cycles versus obese women…
- Conditions
- Weight Loss, Anovulation, Amenorrhea, Infertility
- Trial name
- NCT01785719
- Testing
- Commercial Weight Loss Program
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cornell University
Mental Illness Persistent, Chronic Disease
Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border
This study evaluated whether patients with severe and persistent mental illness (SPMI) who received coordinated co-located behavioral health and primary care services were more likely to improve health outcomes after 12 months…
- Conditions
- Mental Illness Persistent, Chronic Disease, Hypertension, Diabetes
- Trial name
- NCT03881657
- Testing
- Reverse Colocated Integrated Care, Usual Care
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Health Resources in Action, Inc.
Heart Failure, High Blood Pressure
BVA-200 vs BVA-100 Validation Study
The proposed study is a prospective, observational, investigator and patient blinded study comparing the results of blood volume measurement using the FDA-cleared Daxor BVA-100 device to the Daxor BVA-200 device.
- Conditions
- Heart Failure, High Blood Pressure, High Cholesterol, Anemia
- Trial name
- NCT06227819
- Testing
- BVA-200
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Daxor Corporation
Chronic Pancreatitis, Diabetes
The Characteristics of Blood Glucose Profile and the Changes of Hormones in PPDM-C Population
The purpose of this study was to explore the characteristics of blood glucose spectrum, changes of endocrine/exocrine pancreatic function and the correlation between them in patients with PPDM-C.
- Trial name
- NCT06826729
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Dehydration
Oral Rehydration Solution and Dehydration Recovery
This is a prospective, randomized, controlled, blinded, crossover, study to evaluate the effects of an oral hydration solution.
- Trial name
- NCT06368765
- Testing
- Oral Rehydration Solution (ORS), Water
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Obesity, Lipid Metabolism
Metabolic Fate Modifications of Saturated Fats After an Overfeeding
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding.
- Conditions
- Obesity, Lipid Metabolism, Inflammation
- Trial name
- SURNUT (NCT00905892)
- Testing
- Hyperlipidic overfeeding
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Fatty Liver
Effect of Diet Composition on Liver Fat and Glucose Metabolism
This study is designed to determine if the amount of fat and saturated fat in the diet contributes to the development of a condition called fatty liver disease in the absence of changes in weight.
- Trial name
- DietLFAT (NCT00930371)
- Testing
- high fat/high saturated fat diet, low fat/low saturated fat diet
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Microbial Colonization
Microbiome Derived Metabolism and Pharmacokinetics
The investigators will perform single-dose pharmacokinetic (PK) studies in humans following administration of drugs with known microbiome derived metabolism (MDM) in parallel with preclinical studies.
- Trial name
- MDM-PK (NCT05065671)
- Testing
- Tolcapone 100 MG, Duloxetine 20 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Total Intravenous Anesthesia, Desflurane
TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery
Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery.
- Conditions
- Total Intravenous Anesthesia, Desflurane, Obesity, Pain, Postoperative
- Trial name
- NCT03727607
- Testing
- Desflurane
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Aneuploidy, Infertility
Nuclear Magnetic Resonance for Embryo Ploidy Selection
This study aims to validate the embryo culture medium analysis by nuclear magnetic resonance spectroscopy, as a faster and less-costly alternative to preimplantation genetic test for aneuploidy which could significantly enhance…
- Trial name
- NCT05488236
- Testing
- Nuclear magnetic resonance analysis of embryo culture medium
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Cirrhosis, Hepatic Encephalopathy
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.
- Trial name
- NCT00424957
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
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