Clinical trials: Processes, Metabolic
Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3
Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy
The goal of this clinical trial is to compare the efficacy of L-ornithine L-aspartate and Polyethylene Glycol in Cirrhotic Patients with Overt Hepatic Encephalopathy.
- Conditions
- Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3, Hepatic Encephalopathy Stage 4
- Trial name
- NCT05920213
- Testing
- Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate
- Where
- 6 sites in Pakistan
- Volunteers
- 360 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Cardiovascular Abnormalities, Chronic Kidney Diseases
Characteristics, Treatment, and Economic Burden of Patients With CVD,CKD or at High Cardiovascular Risk
The heavy disease burden is mainly due to diabetic complications. Diabetes is a major risk factor for cardiovascular disease (CVD) and chronic kidney disease (CKD).China has been the largest absolute disease burden of diabetes in…
- Conditions
- Cardiovascular Abnormalities, Chronic Kidney Diseases, Diabetes
- Trial name
- NCT03958760
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- West China Hospital
Glioma, Glioblastoma
Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
It was previously shown that [18F]Fluorodopa (FDOPA) PET imaging results in intended management changes in 41% of brain tumor patients.
- Conditions
- Glioma, Glioblastoma, Glioblastoma Multiforme
- Trial name
- NCT02176720
- Testing
- FDOPA PET
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The Methodist Hospital Research Institute
Type 1 Diabetes Mellitus (T1DM), End-Stage Renal Disease
Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden
The researchers study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease.
- Trial name
- NCT06883318
- Where
- Sweden
- Volunteers
- 115,000 people
- Sponsor
- Umeå University
Chronic Kidney Disease (Stages 3b-5)
Effect of Probiotic Supplementation on Renal Function, Vascular Calcification and Alterations in Bone Mineral Metabolism in Patients With Chronic Kidney Disease
INTRODUCTION You have been asked to participate in a research study of patients with chronic kidney disease to assess whether a probiotic supplement (a commercially available product that is not a medication) can help slow the…
- Trial name
- MICKID (NCT07260682)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Hyperuricemia, Gout
Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of LC350189
This will be a dose block-randomized, double-blind, active and placebo controlled, single and multiple dosing, dose-escalation study to evaluate tolerability, safety and pharmacokinetic / pharmacodynamic characteristics.
- Trial name
- NCT01361646
- Testing
- LC350189
- Where
- South Korea
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Graft Rejection
Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation
The purpose of this research study is to compare the effects of the two most commonly used anti-T cell induction agents(alemtuzumab and rabbit anti-thymocyte globulin) to prevent rejection in kidney and pancreas transplant…
- Trial name
- NCT00331162
- Testing
- Alemtuzumab, Anti-Thymocyte Globulin
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Kidney Disease, Diabetes
Effects of Febuxostat on Adipokines and Kidney Disease in Diabetic Chronic Kidney Disease
Hyperuricemia is emerging as a risk factor for development of diabetes and metabolic syndrome. Recently, it was shown in in-vitro cell culture experiments that hyperuricemia induces redox-dependent signaling and oxidative stress…
- Trial name
- NCT01350388
- Testing
- Febuxostat
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Gaucher Disease
Exploration of Immunity in Gaucher Disease
Gaucher disease (GD), the inherited deficiency of the lysosomal enzyme glucocerebrosidase is characterized with accumulation of abnormal lipid in cells of the immune system, called macrophages.
- Trial name
- NCT01358188
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- O & O Alpan LLC
Colorectal Cancer (Diagnosis), Malnutrition or Risk of Malnutrition
Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial
This clinical study aims to evaluate whether short-term personalized nutritional support, when combined with structured health education, can improve nutritional status, quality of life, and clinical outcomes in patients who have…
- Trial name
- NUTRI-CRC (NCT07087561)
- Testing
- Personalized Oral Nutritional Supplementation, Personalized Parenteral Nutritional Supplementation, Structured Nutrition-Focused Health Education
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Xiaoqin Luo
Dehydration
Ratio of Inferior Vena Cava and Aorta Diameter in Dehydrated Children
There is no definite tool for measurement of dehydration in children Subjective clinical dehydration scale is considered as valuable scoring system, but it cannot be reliable among clinicians sometimes.
- Trial name
- NCT02203123
- Testing
- Ultrasound, normal saline
- Where
- South Korea
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Infections, Heart Failure
Rural Hospital-Level Care at Home for Acutely Ill Adults
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infections, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05256303
- Testing
- Home Hospital care, Traditional Hospital care
- Where
- 3 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 1
Teens-Connect: Preventive Psycho-education for Transitioning Teens With Diabetes
The purpose of this study is to evaluate the use of a state-of the art internet psycho-educational program in clinical practice (Teens-Connect), compared to use of a standard and widely available internet diabetes program for…
- Trial name
- TeensConnect (NCT01783327)
- Testing
- Teens-Connect, Planet D
- Where
- 2 sites in United States
- Volunteers
- 124 people
- Sponsor
- Yale University
Urea Cycle Disorder
A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders
This is an open-label study consisting of a transition period to RAVICTI, followed by a safety extension period for at least 6 months and up to 24 months of treatment with RAVICTI, depending on age at enrollment.
- Trial name
- NCT02246218
- Testing
- RAVICTI
- Where
- 17 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- Amgen
Hypophosphatasia
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study
Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP…
- Trial name
- COHIRnational (NCT06574282)
- Testing
- Second alkaline phosphatase measurement
- Where
- Germany
- Volunteers
- 720 people
- Sponsor
- University of Bonn
ICU Delirium, Critical Illness
Exogenous Ketone Supplementation in ICU Delirium
Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, struggle to pay attention, or see and hear things that are not real.
- Trial name
- KETONES-ICU (NCT07364162)
- Testing
- Ketone monoester
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Diabetic Cardiomyopathy, Diabetes Mellitus Type 2
REmodelling in Diabetic CardiOmapathy: Gender Response to PDE5i InhibiTOrs
Pathophysiology of diabetic cardiomyopathy (DCM) is yet unclear and gender differences at baseline and a specific treatment have not been indicated.
- Trial name
- RECOGITO (NCT01803828)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Roma La Sapienza
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Endometrial Cancer, Metastasis
ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer
Endometrial cancer (EC) is the fourth most common cancer in United States women, and alarmingly, the frequency and mortality from EC continues to rise, in part due to the obesity epidemic.
- Conditions
- Endometrial Cancer, Metastasis, Endometrioid Endometrial Cancer, Carcinosarcoma
- Trial name
- NCT05542407
- Testing
- Atezolizumab, ONC201
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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