Clinical trials: Prodromal Parkinson Disease
Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD)
Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study
The study aims to provide initial proof-of-concept validation data of an artificial intelligence-based model to estimate individual Parkinson's disease risk using demographic, clinical, genetic information and digital biomarker…
- Conditions
- Parkinson Disease (PD), REM Sleep Behavior Disorder (iRBD), Neurogenic Orthostatic Hypotension, Hyposmia
- Trial name
- AI-PRA (NCT07706829)
- Testing
- Smartwatch and phone app
- Where
- 3 sites in France, Spain and 1 more
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Parkinson Disease
Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression
This is a observational, multi-center study to assess progression of clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients compared to healthy controls (HC) and in PD patient subtypes.
- Trial name
- PPMI (NCT01141023)
- Testing
- DaTscan
- Where
- 34 sites in United States, Australia and 9 more
- Volunteers
- 952 people
- Sponsor
- Ken Marek, MD
Parkinson Disease (PD), Type 1 Gaucher Disease
Parkinson's Disease in Type 1 Gaucher Disease
Parkinson's disease (PD) is an age-related movement disorder with a complex pathophysiology. Among the risk factors for PD, variants in beta-glucocerebrosidase (encoded by the gene GBA1) represent one of the most significant…
- Trial name
- NCT07886879
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Parkinson Disease
Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
The PASS-PD study is set out to screen individuals from the general population with an increased risk for the development of Parkinson's Disease (PD) and to investigate this highly enriched cohort longitudinally for five year.
- Trial name
- PASS-PD (NCT04724941)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Polyneuropathy, Alpha-Synucleinopathy
Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System
Description of a method to detect Parkinson's disease or Parkinson's-like disease at an early stage (Prodromal Parkinson's Disease) where damage is still confined to the peripheral nervous system damage.
- Conditions
- Polyneuropathy, Alpha-Synucleinopathy, Lewy Body Disease, Parkinson Disease (PD)
- Trial name
- Prompark (NCT06745011)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium Stage 2
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies
- Trial name
- NAPS2 (NCT05826457)
- Where
- 9 sites in United States, Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Prodromal Parkinson's Disease
A Comparative Performance Study Between High and Standard Resolution Positron Emission Tomography Camera Using [18F] AV-133 in Prodromal Parkinson's Disease
This study is a single-center, longitudinal study and will be conducted at the Institute for Neurodegenerative (INDD) Site in New Haven, CT.
- Trial name
- NCT07809438
- Testing
- [18F] AV-133 PET Imaging
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Mild Cognitive Impairment, Mild Dementia
NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's Disease or Lewy Body Dementia (Cognition, Memory, Attention, Thinking)
A Study to Evaluate NYX-458 in Subjects With Mild Cognitive Impairment or Mild Dementia Associated With Parkinson's Disease or Prodromal or Manifest Lewy Body Dementia
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Parkinson Disease, Lewy Body Disease
- Trial name
- NCT04148391
- Testing
- NYX-458
- Where
- 26 sites in United States
- Volunteers
- 99 people
- Sponsor
- Aptinyx
Pesticide-Induced Parkinsonism
Pesticides and Parkinson´s Disease
The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs…
- Trial name
- Pest-PD (NCT06420310)
- Testing
- exposure to pesticides
- Where
- Spain
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Burgos
Idiopathic REM Sleep Behavior Disorder, Parkinson Disease
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual
This study aims to characterize neurodegeneration progression in patients with polysomnography (PSG)-confirmed longstanding idiopathic REM sleep behavior disorder (iRBD) and to develop a prognostic model for clinical evolution…
- Conditions
- Idiopathic REM Sleep Behavior Disorder, Parkinson Disease, Neurodegeneration, Prodromal Parkinson Disease
- Trial name
- iRBD (NCT07729748)
- Testing
- Multiparametric clinical, neuropsychological, PSG and MRI assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Healthy, Prodromal Alzheimer's Disease
Exploring the Gut-Brain Axis in Ageing and Neurodegeneration
Neurodegenerative diseases are a major health concern due to their growing societal implications and economic costs. The identification of early markers of pathogenic mechanisms is one of the current main challenges.
- Conditions
- Healthy, Prodromal Alzheimer's Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- GutBrain (NCT05934188)
- Testing
- Magnetic Resonance Imaging, Neuropsychological protocol, Eating habits
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Neurodegenerative Diseases, Parkinson Disease
Saliva and Extracellular Vesicles for Neurodegenerative Diseases
Early diagnosis of Neurodegenerative diseases (NDDs) and accurate patient profiling are key goals needed to tailor prompt personalized therapeutic strategies that can significantly impact disease progression and patients' quality…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Alzheimer Disease, Parkinsonism
- Trial name
- MINERVA (NCT06869135)
- Testing
- Saliva collection, longitudinal
- Where
- 5 sites in Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Prodromal Parkinsons Disease
Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)
The study is a longitudinal, multi-center study to assess progression of [18F] AV-133 imaging in Prodromal PD participants. Participants will be followed for up to 24 months.
- Trial name
- NCT07265596
- Testing
- [18F] AV-133 PET Imaging
- Where
- 8 sites in United States, Canada and 4 more
- Volunteers
- 100 people
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
REM Sleep Behavior Disorder, Synucleinopathies
A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBD
Comprehensive characterization of early-stage Parkinson's disease in patients with REM sleep behavior disorder Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder worldwide, significantly affecting quality…
- Conditions
- REM Sleep Behavior Disorder, Synucleinopathies, Parkinson's Disease (PD), Prodromal Parkinson's Disease
- Trial name
- 7T-RBD (NCT07790744)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
REM Sleep Behavior Disorder, Parkinson Disease
Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease
To investigate whether a year of rasagiline may reduce the progression from idiopathic REM sleep behavior disorder (RBD) to Parkinson's disease (PD).
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Synucleinopathies
- Trial name
- NCT05611372
- Testing
- Rasagiline
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson Disease
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of…
- Trial name
- PPMI (NCT04477785)
- Where
- 50 sites in United States, Austria and 10 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson Disease, Prodromal Stage
Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands
The goal of this clinical trial is to investigate the feasibility if a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in patients with isolated Rapid Eye Movement…
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Parkinsonian Disorders
- Trial name
- Slow-SPEED-NL (NCT06193252)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Early Longitudinal Imaging in Parkinson's Progression Markers Initiative Using [¹⁸F] AV-133 and DaTscan™
Directly examine whether early (6-month) imaging with DaTscan and [¹⁸F] AV-133 will provide an early signal of disease progression in recently diagnosed untreated PD patients.
- Trial name
- NCT04507139
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson Disease (PD), PARKINSON DISEASE (Disorder)
GBPDC: Gut-Brain in PD Consortium Master Protocol
The purpose of this research study is to identify the role that the gut-brain axis, the group of nerves that connect the brain and gut, plays in Parkinson's disease (PD).
- Conditions
- Parkinson Disease (PD), PARKINSON DISEASE (Disorder), Gut Microbiome, Gut Microbiota
- Trial name
- GBPDC (NCT07567794)
- Where
- 7 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Duke University