Clinical trials: Progesterone
Fetal Growth Restriction, Placenta
Placental Progesterone Membrane Receptors in Fetal Growth Restriction
This prospective observational case-control study aims to compare placental expression levels of progesterone membrane receptors, including PGRMC1, PGRMC2, and PAQR family receptors, among pregnancies affected by impaired fetal…
- Conditions
- Fetal Growth Restriction, Placenta, Progesterone Membrane Receptor, PGRMC1
- Trial name
- NCT07701837
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Samsun University
Fertility, Mobile Applications
Smartphone vs Manual Interpretation of Biomarkers for Ovulation and Luteal Phase Detection (SMOM Study)
This study will compare different combinations of fertility signs (cervical mucus (CM), luteinizing hormone [LH], pregnanediol glucuronide [PDG], and basal body temperature [BBT]) to determine which are most reliable for…
- Conditions
- Fertility, Mobile Applications, Artifical Intelligence, Cervical Mucus
- Trial name
- SMOM (NCT07248046)
- Testing
- Premom App-Assisted Fertility Tracking
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bruyère Health Research Institute.
Healthy Volunteers, Female
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM®) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
- Conditions
- Healthy Volunteers, Female, Progesterone, Premenopausal
- Trial name
- MP4 MPS (NCT07173361)
- Testing
- Micronized progesterone (oral capsules)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Menstrual Cycle, Luteal Phase Progesterone Levels
Corpus Luteum Function and Cardiovascular Adaptation in a Natural MOCK Cycle.
In infertility treatment, embryos are created in vitro after eggs have been fertilised by sperm using in vitro fertilisation or intracytoplasmic sperm injection techniques.
- Conditions
- Menstrual Cycle, Luteal Phase Progesterone Levels, Luteal Phase Adaptation, MOCK Cycle
- Trial name
- CLEAR (NCT07648381)
- Testing
- Blood samples for the analysis of biomarkers., Transvaginal ultrasound for follicle and endometrium measurements., Mean Arterial Pressure measurement.
- Where
- Belgium
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
Nipple Aspirate Fluid in Detecting Breast Cancer
This trial studies nipple aspirate fluid in detecting breast cancer. Nipple aspirate fluid may better detect breast cancer earlier than current methods used for screening such as mammograms and breast examinations.
- Conditions
- Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
- Trial name
- NCT03715959
- Testing
- Aspiration of Breast, Biospecimen Collection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Endometrial Endocrine Regulation, Progesterone Supplementation in Women After Mifepristone
Endometrial Transcript Profile with Progesterone After Post-ovulatory Mifepristone
The goal of this exploratory trial is to determine the endometrial gene expression profile induced by exogenous progesterone after postovulatory administration of mifepristone.
- Trial name
- NCT06616077
- Testing
- Micronized Progesterone 600 mg, mifepristone 200 mg
- Where
- Chile
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Reproductive Health Research Insritute, Chile
HER2-positive Breast Cancer, HER2 Low
ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer
This is an open-label, single-arm, multi-site phase I/Ib trial with SYD985, an antibody-drug conjugate (ADC) targeting HER2 on the cell membrane, combined with paclitaxel.
- Conditions
- HER2-positive Breast Cancer, HER2 Low, SYD-985, SYD985
- Trial name
- NCT04602117
- Testing
- Vic-trastuzumab duocarmazine (SYD985) + paclitaxel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QuantumLeap Healthcare Collaborative
Endometrial Hyperplasia Without Atypia, Endometrial Hyperplasia With Atypia
Endometrial Tissues and Mononuclear Cells Receptivity in Pathogenesis of Endometrial Proliferative Processes
A prospective observational study of endometrial tissue and peripheral blood mononuclear cells receptivity to sex steroid hormones in postmenopausal patients with endometrial proliferative processes
- Conditions
- Endometrial Hyperplasia Without Atypia, Endometrial Hyperplasia With Atypia, Endometrial Cancer, Peripheral Blood Mononuclear Cells
- Trial name
- NCT06115577
- Testing
- endometrial tissue and peripheral blood mononuclear cells receptivity
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Pirogov Russian National Research Medical University
Infertility, IVF
The Importance of Embryo Transfer Day Progesterone Value in Natural Cycle Frozen Embryo Transfers and the Evaluation of the Effect of Rescue Therapy on Pregnancy Outcomes in Patients With Low Progesterone Levels
Thanks to recent advances in clinical practice and laboratory, embryo cryopreservation has become the first-line procedure in assisted reproductive technology.
- Conditions
- Infertility, IVF, Progesterone
- Trial name
- NCT05481684
- Testing
- Normal Progesterone group, Low Progesterone group
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Premature Luteinisation, Progesterone Elevation
Ovarian Stimulation With FSH Alone Versus FSH Plus GnRH Antagonist in an Oocyte Donor/Recipient Programme
The aim of this study is to compare the efficacy of a protocol using FSH alone with that of a protocol using FSH plus a GnRH antagonist for controlled ovarian hyperstimulation in cycles of elective freezing in the context of a…
- Trial name
- NCT05759871
- Testing
- GnRH antagonist
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Progesterone, Contraceptive Methods
Progesterone Containing Contraceptive Methods on Endogenous Progesterone Level
The aim of this study is to assess the effect of different progesterone containing contraceptive methods on safety and endogenous progesterone level
- Trial name
- NCT05742503
- Testing
- Depo-Provera, Implanon, Norgestrel
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
Progesterone
Comparison of the Effect of Subcutaneous Progesterone and Vaginal Progesterone for Luteal Phase Support
The invesigators aimed to seperate the patients,which is going to be applied IUI, to two different groups as prospective randomized controlled ;assess the efficacy of the two different way pressurised progesterone by appling…
- Trial name
- NCT05276531
- Testing
- subcutaneous progesterone, vaginal progesterone
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Luteal Phase Progesterone Levels
The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates
Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4…
- Trial name
- NCT04128436
- Testing
- Taking blood samples for analyzing progesterone levels
- Where
- 3 sites in Brazil, Denmark and 1 more
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Progesterone, Luteal Phase Support
Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Luteal phase support in "in vitro fertilization" (IVF) cycles has been shown to improve pregnancy rates and became a standard of treatment, and progesterone is the first choice considering its safety profile and effectiveness.
- Conditions
- Progesterone, Luteal Phase Support, In Vitro Fertilization
- Trial name
- PROPER-1 (NCT03734770)
- Testing
- Subcutaneous Progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Menopause, Progesterone
Progesterone and Resting Energy Expenditure
This study evaluates the effect of micronized progesterone substitution in the luteal phase on resting energy expenditure in women during menopausal transition.
- Conditions
- Menopause, Progesterone, Weight Gain
- Trial name
- P4&REE (NCT04140968)
- Testing
- Utrogestan
- Where
- Switzerland
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Relationship of Progesterone Levels and Pregnancy
The Effect of Progesterone Levels on Pregnancy
The aim of this study is to investigate the effect of progesterone levels on pregnancy occurrence on the 3rd and 5th days after insemination.
- Trial name
- NCT04707430
- Testing
- blood progesterone test
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Sezcan Mumusoglu
Infertility, IVF
Effects of E2, P4 and LH Levels on the Day of Transfer and Endometrial Cavity Thickness on Implantation Success in Patients With Frozen-thawed Embryo Transfer Cycle
Thanks to recent advances in clinical practice and laboratory, embryo cryopreservation has become the first-line procedure in assisted reproductive technology.
- Conditions
- Infertility, IVF, Progesterone
- Trial name
- NCT04769401
- Testing
- Normal Progesterone group, Low Progesterone group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Polycystic Ovary, Progesterone Resistance
Progesterone Action on Endometrium of PCOS
Objective: To study the influence of metabolic factors on the action of progesterone on the endometrium of women with PCOS. Design: A prospective open-label clinical trial.
- Trial name
- NCT05062135
- Testing
- Progesterone 400 Mg Vaginal Suppository on PCOS
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Progesterone Resistance
Step Down FSH Approach and Late Follicular Phase in Progesterone Level
Step-down approach and late follicular phase progesterone level
- Trial name
- FSH (NCT03356964)
- Testing
- follicle stimulating hormone
- Where
- United Arab Emirates
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC