Clinical trials: Progesterone, open to volunteers
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Puberty, Hyperandrogenism
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than…
- Trial name
- CRM003 (NCT00929006)
- Testing
- Micronized progesterone suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Infertility, Female, Infertility
Is the AMH Intrafollicular Level a Predictor of the Ploidy Status of the Blastocyst?
To investigate, whether on the day of egg retrieval, after ovarian stimulation for ICSI (intracytoplasmic sperm injection), there is a correlation between the intrafollicular AMH (Anti-Müllerian hormone) levels and the ploidy…
- Trial name
- NCT05837325
- Testing
- Oocyte Pick Up - Out of Study, Denudation - Out of Study, ICSI
- Where
- United Arab Emirates
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Transgender Women
Progesterone in Gender Affirming Hormone Therapy Study
This study aims to study the effects of Oral Progesterone in Transgender Women. The primary goal is to study the effect of progesterone on psychological distress and secondarily on sleep quality, breast size, quality of life and…
- Trial name
- NCT06807580
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Luteal Support, Frozen Embryo Transfer (FET)
Is There a Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles
Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product.
- Trial name
- NCT06875752
- Testing
- no luteal support, Vaginal Progesterone, Progesterone plus HCG
- Where
- 5 sites in Hungary
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Dunamenti REK Istenhegyi IVF Center
Premenstrual Dysphoric Disorder ( PMDD)
To Establish Whether Individuals With Premenstrual Dysphoric Disorder (PMDD) Demonstrate a Different Luteal-phase Sex Hormone Profile and Ratio Compared With Asymptomatic Controls.
The aim of this project is to compare the ovarian hormone levels 7 days after ovulation and progesterone:oestradiol ratios between PMDD individuals and a control cohort (case control study).
- Trial name
- NCT07686718
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Infertility, Female
Impact of Serum Progesterone Levels on the Day of β-hCG Test in Artificial Cycles on the Ongoing Pregnancy Rate.
Prospective cohort multicentric study including infertile patients undergoing a pregnancy test on βhCG day (around ET +11), after an ET in the context of an artificial cycle and receiving LPS with vaginal natural progesterone…
- Trial name
- P4-BETA (NCT05750849)
- Testing
- BLOOD COLLECTION FOR P4 DETERMINATION
- Where
- Spain
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Preterm Birth
Prolonged Progesterone to Prevent Preterm Birth From IVF - ET
To investigate the incidence of preterm birth in IVF fresh embryo transplantation cycle patients after prolonged vaginal progesterone treatment
- Trial name
- NCT05787509
- Testing
- Progesterone Sustained-release vaginal gel
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, Female
Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle.
To describe the peripheral serum levels of the anti-inflammatory cytokines IL-4 (Interleukin-4), IL-10 (Interleukin-10), TGF-ß1 (Transforming Growth Factor beta1), the pro-inflammatory cytokines IL-17 (Interleukin-17), IFγ…
- Trial name
- NCT05473273
- Testing
- Endometrin 100Mg Vaginal Insert, Estradiol Valerate
- Where
- United Arab Emirates
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Circadian Rhythm, Menstrual Cycle Phase
Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance
This study is designed to determine whether time-of-day and menstrual cycle phase influence athletic performance and is expected to contribute valuable insight into how both time-of-day, and hormonal factors can influence…
- Conditions
- Circadian Rhythm, Menstrual Cycle Phase, Female Athletes, Executive Function (Cognition)
- Trial name
- NCT07399847
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Infertility Assisted Reproductive Technology
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical…
- Trial name
- NCT07858227
- Testing
- data collection
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Preeclampsia, Preeclampsia Complications
Role of Progesterone Membrane Receptors in the Pathogenesis of Preeclampsia
Preeclampsia is a pregnancy-specific hypertensive disorder and remains a leading cause of maternal and perinatal morbidity and mortality worldwide.
- Trial name
- NCT07745036
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Samsun University
GnRH Antagonist IVF Protocol, Fresh Embryo Transfer
GnRH for Luteal Support - Mechanism of Action
This prospective observational study will include women undergoing IVF treatment with a GnRH antagonist protocol and fresh embryo transfer at the IVF unit of Shaare Zedek Medical Center.
- Conditions
- GnRH Antagonist IVF Protocol, Fresh Embryo Transfer, Administration of Hormonal Luteal Support
- Trial name
- NCT07620067
- Testing
- GnRH agonist, Progesterone
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Heli Alexandroni
Pre Term Birth
Comparing the Pharmacokinetics of a Progesterone Ring Versus a Progesterone Vaginal Insert
This study is looking for healthy female adults to use an vaginal ring with differing amounts of the hormone progesterone and go through a series of blood draws to measure how much progesterone is in the body following the use of…
- Trial name
- NCT06668896
- Testing
- Progesterone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Daré Bioscience, Inc.
Energy Balance, Physiology - Regulation of Appetite and Food Intake
The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance
The goal of this study is to determine if estradiol and progesterone are involved in appetite regulation and energy balance. The study aims to complete a 13 day randomized controlled trial (RCT) where oral supplementation of…
- Trial name
- E2 & P4 in EB (NCT07620587)
- Testing
- Estradiol Only, Progesterone Only, Estradiol and Progesterone Combination
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wilfrid Laurier University
Fertility, Implantation, Embryo
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
This study looks at progesterone, a hormone that prepares the womb lining (endometrium) for pregnancy, in women having a frozen embryo transfer after IVF.
- Trial name
- PROMICOFET (NCT07818278)
- Testing
- Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Hyperandrogenism, Polycystic Ovary Syndrome
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CRM008 (NCT03068910)
- Testing
- Micronized progesterone, Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Menstrual Cycle, Luteal Phase Progesterone Levels
Corpus Luteum Function and Cardiovascular Adaptation in a Natural MOCK Cycle.
In infertility treatment, embryos are created in vitro after eggs have been fertilised by sperm using in vitro fertilisation or intracytoplasmic sperm injection techniques.
- Conditions
- Menstrual Cycle, Luteal Phase Progesterone Levels, Luteal Phase Adaptation, MOCK Cycle
- Trial name
- CLEAR (NCT07648381)
- Testing
- Blood samples for the analysis of biomarkers., Transvaginal ultrasound for follicle and endometrium measurements., Mean Arterial Pressure measurement.
- Where
- Belgium
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Luteal Phase Insufficiency
Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels.
- Trial name
- CineP4 (NCT07028710)
- Testing
- hCG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC