Clinical trials: Prognosis
Asthma Exacerbations
A Cohort Study of Risk Factors and Prognosis for Frequent Acute Asthma Exacerbations Phenotype
Acute asthma exacerbations are an important public health problem and a major cause of disease progression and healthcare burden for people with asthma. Frequent acute exacerbations are likely to be a distinct asthma phenotype.
- Trial name
- NCT06621056
- Testing
- not applicable for observational research
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Urinary Tract Infections
DIagnoSing Care hOme UTI Study
The number of care home residents is increasing and urinary tract infections (UTIs) are common amongst this group. Accurate diagnosis of UTI is important because not treating an infection may lead to serious consequences…
- Trial name
- DISCO UTI (NCT05880329)
- Testing
- Candidate POCTs for detecting UTI
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Healthy People, Benign Prostatic Hyperplasia
The Application of Multimodal Artificial Intelligence Systems in Prostate Cancer Diagnosis and Prognosis Analysis
Prostate-specific antigen (PSA) testing has limited specificity for prostate cancer diagnosis, leading to a high rate of unnecessary biopsies.
- Conditions
- Healthy People, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06589154
- Testing
- Multi-modal artificial intelligence model (BEAM)
- Where
- 10 sites in China
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Acute Coronary Syndrome
The Role of Netrin -1 in Acute Coronary Syndrome
In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher…
- Trial name
- ACS-NETRİN-1 (NCT04027127)
- Testing
- netrin-1 value on admission to hospital
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Septic Shock, Sepsis, Severe
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
The sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies.
- Trial name
- suPAR (NCT04459572)
- Testing
- suPAR
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Incontinence Associated Dermatitis
Development of a Risk Assessment Tool for Incontinence-associated Dermatitis (IAD): a Cohort Study on the Predictive Performance of Risk Factors for IAD
Objective: The primary goal of this prospective cohort study is to collect data on specific factors, including age, sex, stool consistency, etc. and assess their association with the development of IAD.
- Trial name
- INCONTECT (NCT06978751)
- Where
- 7 sites in Belgium, Sweden
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Coronary Heart Disease, Image
Research on the Relationship Between Cognitive Function Changes and Cerebrovascular Health in Patients With Coronary Heart Disease
The purpose of this study is to elucidate the imaging mechanisms of cognitive function changes in patients with coronary heart disease before and after surgery or conservative treatment, and to evaluate and predict the…
- Trial name
- NCT05848934
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Coma
Multimodal Resonance Imaging for Outcome Prediction on Coma Patients
Stroke, traumatic head injury, subarachnoid hemorrhage and cerebral anoxia are main causes of a coma condition implying severe brain damage and thus, poor prognosis.
- Trial name
- MRI-Coma (NCT00577954)
- Testing
- Multimodal MRI
- Where
- France
- Volunteers
- 417 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV
The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer
Aberrant miRNA production has been linked to a wide range of human cancers and shown to play important roles in their genesis and growth. These miRNA can be detected in the blood and tumors of patients with cancer.
- Conditions
- Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV, Pancreatic Ductal Adenocarcinoma, Pancreatic Neoplasms
- Trial name
- NCT04406831
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nuvance Health
Sepsis
Early Identification and Prognosis Prediction of Sepsis Through Multiomics
This study aims to integrate multi-omics data and clinical indicators to reveal pathogen-specific molecular patterns in patients with sepsis and establish prognostic prediction models through multiple machine learning algorithms.
- Trial name
- EIPPSM (NCT05305469)
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Yantai Yuhuangding Hospital
Stroke
SH-SS and GSH-GSSG Homeostasis in Post-stroke Patients
In patients undergoing physical therapy after stroke, extracellular thiol-disulfide balance and intracellular oxidized-reduced glutathione balance levels will be monitored.
- Trial name
- NCT04884555
- Testing
- Standard neurorehabilitation, Thiol-Disulphide Homeostasis, Oxidized-reduced Glutathione Homeostasis
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Hypoparathyroidism
Hypoparathyroidism in Denmark
The purpose of this study is to identify the number of persons in Denmark with the diagnose hypoparathyroidism, autosomal dominant hypocalcaemia or pseudohypoparathyroidism.
- Trial name
- HypoPT (NCT01498341)
- Where
- Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Liver Diseases, Liver Cancer
Breath Analysis Based Disease Biomarkers
The purpose of the study is to develop a clinical test based on breath analysis that can be used for disease diagnosis or prognosis.
- Conditions
- Liver Diseases, Liver Cancer, COVID19
- Trial name
- NCT04341012
- Testing
- Collection of breath sample
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Brain Hemorrhage
Prognostic Analysis of Different Treatment Options for Cerebral Hemorrhage
To analyze the influence of early hematoma morphology on hematoma expansion, optimize the treatment plan for cerebral hemorrhage, and guide the treatment of patients with cerebral hemorrhage in combination with clinical practice.
- Trial name
- NCT05548530
- Testing
- Stereotactic intracranial hematoma puncture, decompressive craniectomy, Neuroendoscopic
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Connective Tissue Diseases, Pulmonary Hypertension
Connective Tissue Disease Patients With Pulmonary Hypertension
Adult patients with suspected or confirmed Connective Tissue Disease Patients (CTD)With Pulmonary Hypertension(PH)will be recruited.
- Trial name
- NCT05980728
- Testing
- No Intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Alzheimer Disease, Lewy Body Dementia (LBD)
The Role of Advanced Electroencephalographic Data as Marker of Pathology and Prognosis in Primary Dementias
The study aims to use advanced brainwave recordings of electroencephalogram (EEG) to understand early signs of Alzheimer's disease (AD) in people with mild memory problems, known as amnestic Mild Cognitive Impairment (MCI).
- Conditions
- Alzheimer Disease, Lewy Body Dementia (LBD), Mild Alzheimer Disease, Frontotemporal Dementia (FTD)
- Trial name
- NCT06826157
- Testing
- Electroencephalogram, 3 Tesla MRI, Apolipoprotein E genetic test
- Where
- Italy
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depression, Treatment Resistant Depression
Computational Psychiatric Approach to Depression
The purpose of this research is to investigate how the brain changes in patients undergoing electroconvulsive (ECT) treatment for depression.
- Trial name
- NCT04189939
- Testing
- clinical assessments
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post Traumatic Stress Disorder, Postoperative Complications
PTSD of Surgeons or Anesthesiologists on Prognosis of Surgical Patients
The objective of this prospective cohort study is to explore the association between the development of post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists and postoperative prognosis in surgical patients they…
- Conditions
- Post Traumatic Stress Disorder, Postoperative Complications, COVID-19
- Trial name
- NCT05732116
- Testing
- PTSD
- Where
- 2 sites in China
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
Immunohistochemical Expression of EGFR in the Patients Having Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is one of the top 10 most common malignancies worldwide. Oral squamous cell carcinoma forms a major health problem in many countries.
- Trial name
- EGFR (NCT06606301)
- Testing
- BioSB EGFR antibody
- Where
- Pakistan
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital, Pakistan