Clinical trials: Prognostic Biomarkers
Inflammatory Bowel Diseases, Crohn Disease
IDENTIFICATION OF PROGNOSTIC AND PREDICTIVE BIOMARKERS IN INFLAMMATORY BOWEL DISEASE
Interventional study of a group of patients with an inflammatory bowel disease (IBD; Crohn's disease (CD) or ulcerative colitis (UC)) to identify predictive and prognostic biomarkers of natural history and response to…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- i-BANK (NCT03809728)
- Testing
- endoscopic biopsy, samples of the oral cavity, Samples of the resected specimen
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Central Hospital, Nancy, France
Endometrial Cancer
Analysis of miRNA Expression in Endometrial Cancer
The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) the hypermutated subtype…
- Trial name
- MIRCE (NCT04845425)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cervical Spondylotic Myelopathy
Biomarkers of Cervical Spondylotic Myelopathy
Investigators believe that patients with cervical spondylotic myelopathy (CSM) have measurable changes in certain molecules in their blood compared with people without CSM.
- Trial name
- NCT07772297
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sepsis
Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and increased mortality.
- Trial name
- EMR3-SEPSIS (NCT07896018)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Diabetes Mellitus, Biomarker
Study of Biomarkers in Diabetic Chronic Wounds
This study aims to discover, verify and evaluate the potential biomarkers with regard to the diagnosis, prognostic and/or prediction of diabetic chronic wounds.
- Conditions
- Diabetes Mellitus, Biomarker, Chronic Wound
- Trial name
- NCT05342740
- Testing
- collect whole blood, urine and stool samples
- Where
- China
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Yibing Wang
Breast Cancer, Early Stage Breast Cancer
Pooled Analysis of Patients With Early-stage Breast Cancer Treated With Adjuvant Dose-dense Sequential Chemotherapy: a Hellenic Cooperative Oncology Group (HeCOG) Study.
The goal of this observational study is to assess survival outcomes and treatment-related toxicity in patients with early-stage breast cancer receiving adjuvant therapies, using high-quality individual patient data pooled from…
- Conditions
- Breast Cancer, Early Stage Breast Cancer, Adjuvant Chemotherapy, Prognosis Breast Cancer
- Trial name
- ΗE_10R/22 (NCT07521397)
- Where
- Greece
- Volunteers
- 5,358 people
- Sponsor
- Hellenic Cooperative Oncology Group
MDS, Cardiovascular Diseases
Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients With Myelodysplasia
This study evaluates the relationship between myelodysplastic syndromes (MDS) and cardiovascular disease. MDS patients will be evaluated for the presence of mutations and whether they are associated with an increased risk of…
- Conditions
- MDS, Cardiovascular Diseases, Inflammation
- Trial name
- NCT04110925
- Testing
- Genetic Mutations, Inflammatory and lipid markers, Computed Tomography (CT) of the heart
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Cancer
Diagnostic and Prognostic Value of MicroRNA in Breast Cancer Patients
The aim of this study is to evaluate the role of miRNA 125a -5p and miRNA143-3p as a non invasive biomarker in diagnosis of breast cancer and the relationship between MiRNA expression and histopathological features as tumor stage…
- Trial name
- NCT04778202
- Testing
- blood sample collection
- Volunteers
- 50 people
- Sponsor
- Assiut University
Community-acquired Pneumonia
Accuracy of Lung Injury Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia
The aim of this study is to investigate the diagnostic and prognostic value of surfactant protein D, Krebs von den Lungen (KL-6), and Chitinase-3-like protein 1 (YKL-40) in the initial investigation of patients hospitalized with…
- Trial name
- NCT04686331
- Testing
- Biomarkers for pneumonia
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
Spinal Tumor
The Value of Preoperative Diagnosis and Prognostic Prediction Based on Radiomics of Giant Cell Tumor of Spine
1. Exploit CT (plain scan), enhanced CT and fMRI based radiomic biomarkers, explore their correlation with the prognostic molecular markers of spinal GCTB(p53/vegf/rank/rankl…), and help accurate diagnosis of GCTB. 2.
- Trial name
- NCT04952818
- Testing
- RANK/RANKL(RANK: Receptor Activator of Nuclear factor Kappa-Β /RANKL:Receptor Activator of Nuclear factor Kappa-Β Ligand)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Chronic Kidney Disease(CKD)
CKD-Heart: Heart Failure Prediction in Asian CKD Patients
Among patients with known chronic kidney disease (CKD) who are free from diagnosed heart failure (HF), some may be classified as stage A-B HF based on the contemporary 2022 ACC/AHA Guideline for Heart Failure Classification.
- Trial name
- NCT06677489
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Mackay Memorial Hospital
Blood Cancer
Development of a Multi-biomarker Panel for Prognostic Stratification and Treatment Response Prediction in Acute Graft Versus Host Disease of the Gut
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a life-saving treatment for many malignant hematologic diseases.
- Trial name
- GUT-PREDICTION (NCT07305090)
- Testing
- Adult and pediatric patients with hematological diseases treated with allogeneic hematopoietic cell transplantation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Contrast-induced Nephropathy
Use of Urinary Cell-Cycle Arrest Biomarkers in Contrast-Associated Nephropathy After Coronary Angiography
Radiological examinations that require the administration of iodinated contrasts (IC) for diagnostic and therapeutic purposes are essential in current clinical practice, and their use in interventional procedures has been…
- Trial name
- NCT04163250
- Testing
- Urinary determination of TIMP-2/ IGFBP7
- Where
- Spain
- Volunteers
- 194 people
- Sponsor
- Eva de Miguel Balsa
Differentiated Thyroid Carcinoma
OnT4-Thyroglobulin Assay Before rhTSH-Aided Radioiodine Ablation
Thyroidectomy followed by administration of large activities of 131-iodine (131I) is the treatment of choice for differentiated thyroid carcinoma (DTC).
- Trial name
- NCT00439127
- Volunteers
- 28 people
- Sponsor
- Oncology Institute of Southern Switzerland
Critically Ill
ICG- Liver Test Versus New Biomarkers as Prognostic Markers in Critically Ill Patients
Comparison of ICG liver testing with copeptin and SAPS II score as prognostic markers in critically ill patients.
- Trial name
- Greenpep (NCT01126554)
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- University of Zurich
Lung Cancer
Biomarkers in Tissue and Blood Samples From Patients With Early-Stage Non-Small Cell Lung Cancer
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01139944
- Testing
- DNA methylation analysis, polymerase chain reaction, laboratory biomarker analysis
- Volunteers
- 99 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Severe Alcoholic Hepatitis
LiverTREM-1: Hepatic TREM-1 Expression and Prognosis in Severe Alcoholic Hepatitis
Background \& Rationale Severe alcohol-related hepatitis (SAH) is a serious condition with a 3-month mortality rate of ~30%. Diagnosis and prognosis are complex due to non-specific and insensitive clinical, biological, and…
- Trial name
- Liver TREM-1 (NCT07176741)
- Testing
- TREM-1 expression (via immunohistochemistry) between SAH patients and controls
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Systemic Inflammatory Response Syndrome, Intensive Care
Prognostic Value of CD64 Marker for Patients in Intensive Care Unit
Among patients admitted to the intensive care unit (ICU), early recognition of those with the highest risk of death is of paramount importance.
- Trial name
- CD64 (NCT03617796)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Preeclampsia
Inflammatory Markers in Pregnant Women Destined to Develop Preeclampsia
The purpose of this study is to assess the predictive role of serum inflammatory markers in pregnant women who subsequently develop preeclampsia.
- Trial name
- NCT01388283
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Carcinoma, Non-Small-Cell Lung
NSE/Alb as a Prognostic Biomarker for Lung Cancer
The incidence and mortality rate of lung cancer is the highest in the world. Current studies have found that tumor markers, inflammatory or nutritional indicators have a good predictive value for the prognosis of patients with…
- Trial name
- NARPBLC (NCT03724604)
- Testing
- Neuron-Specific Enolase to Albumin Ratio
- Where
- China
- Volunteers
- 202 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University