Clinical trials: Prognostic Biomarkers
Non-severe Pulmonary Embolism, Pulmonary Embolism
Interest of the Chair Lift Test in the Prognostic Evaluation of Pulmonary Embolism: a Single-center Open Prospective Study
The objective of the study is to evaluate the prognostic performance of the chair lift test in the initial assessment of the severity of non-severe pulmonary embolism in hospitalized patients, in comparison with the current…
- Conditions
- Non-severe Pulmonary Embolism, Pulmonary Embolism, Non-high-risk Pulmonary Embolism, Pulmonary Embolism Acute
- Trial name
- SIT-EP (NCT06166329)
- Testing
- chair lift test
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Rouen
Neuroendocrine Tumors, Neuroendocrine Neoplasm
Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN)
This is a multicentre, controlled, observational prospective study on new biomarkers, as immune profiling, angiogenetic markers and circRNA from TEPs in the diagnosis and in the evaluation of treatment response in pulmonary and…
- Conditions
- Neuroendocrine Tumors, Neuroendocrine Neoplasm, Neuroendocrine Tumor Grade 1, Neuroendocrine Tumor Grade 2
- Trial name
- REBORN (NCT04464122)
- Testing
- Somatostatin analog; chemotherapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Breast Cancer
Prognostic Value of Biomarkers in HR + / HER2 - Advanced Breast Cancer
Our study is aimed to explore a prospective observational clinical study on the efficacy prediction and survival prediction of HR + / HER2 - biomarkers detection in patients with advanced breast cancer.
- Trial name
- NCT04683770
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Liver Cancer
Trajectory-Based Prognostic Modeling in Hepatocellular Carcinoma
To evaluate whether tracking changes in key blood markers over time, together with clinical features, can improve the prediction of outcomes in patients with hepatocellular carcinoma (HCC).
- Trial name
- NCT07204262
- Testing
- Molecular Targeted Therapy (TKI / anti-VEGF antibody) PD-(L)1 Inhibitor Immunotherapy Interventional Therapy (TACE / HAIC)
- Where
- China
- Volunteers
- 379 people
- Sponsor
- Xu Yong, MD
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Lymphopenia, Covid19
Study of Lymphopenia as a Specific Biomarker or Prognostic Risk Factor for Disease Severity in Elderly Patients With COVID-19
Background: Lymphopenia is reported to be associated with the severity of disease progression in COVID-19. Low lymphocyte count is also associated with increasing age.
- Conditions
- Lymphopenia, Covid19, Older People
- Trial name
- NCT04800731
- Testing
- observation no intervention
- Where
- Belgium
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
IBD - Inflammatory Bowel Disease, COVID - 19
Diagnostic and Prognostic Biomarkers in SARS-CoV-2 Infections
Literature data document that SARS-CoV-2 RNA is present not only in the respiratory tract but also in the feces of infected patients, suggesting a potential additional route of transmission: the oro-fecal route.
- Trial name
- NCT06774638
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer
PET in Breast Cancer Receiving Neoadjuvant Chemotherapy
Prognostic factors in locally advanced breast cancer treated with neoadjuvant chemotherapy differ from those of early breast cancer.
- Trial name
- DA-PET (NCT01396655)
- Testing
- docetaxel (75 mg/m2) and doxorubicin (50 mg/m2)
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital
Non-small Cell Lung Cancer
Exploring Cancer Evolution, Prognostic and Predictive Biomarkers in EGFR-mutant NSCLC
To investigate genomic architecture, cancer evolution and their relationship with clinical outcomes in EGFR-mutant NSCLC.
- Trial name
- NCT05997719
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Pulmonary Hypertension
Circulating Activin-A and FSTL3 in Precapillary Pulmonary Hypertension
The ACTIOBIO study aims to evaluate the prognostic value of Activin-A and FSTL3 in a large cohort of patients with precapillary pulmonary hypertension, including pulmonary arterial hypertension (Group 1), pulmonary hypertension…
- Trial name
- ACTIBIO (NCT07253363)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bacterial Infections, Bacteremia
Procalcitonin Level and Kinetics in Children With Bacterial Infections
The purposes of this study are: 1. To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length 2.
- Conditions
- Bacterial Infections, Bacteremia, Meningitis, Urinary Tract Infection
- Trial name
- NCT00714402
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Immunotherapy Gastrict Cancer, Inflammation Biomarkers
Evaluate the Prognostic Significance of Changes in the Systemic Immune-Inflammation Index in Patients with AGC Treated with ICI Therapy.
The SIIR during neoadjuvant therapy can serve as a specific biomarker for predicting the efficacy of immunotherapy in patients with advanced gastric cancer.
- Conditions
- Immunotherapy Gastrict Cancer, Inflammation Biomarkers, Gastric Cancers
- Trial name
- NCT06706466
- Testing
- observational study
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Chang-Ming Huang, Prof.
Chronic Kidney Diseases, Acute Heart Failure
Prognostic Markers of Acute Heart Failure With Chronic Kidney Disease
Acute heart failure (AHF) is defined as new or worsening of symptoms and signs of heart failure and is the most frequent cause of unplanned hospital admission in elderly patients.
- Conditions
- Chronic Kidney Diseases, Acute Heart Failure, Biomarker
- Trial name
- NCT06006819
- Where
- Taiwan
- Volunteers
- 155 people
- Sponsor
- Cheng-Hsin General Hospital
Autoimmune Diseases, Inflammatory Bowel Diseases
Chronic Inflammatory Disease, Lifestyle and Treatment Response
Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin…
- Conditions
- Autoimmune Diseases, Inflammatory Bowel Diseases, Crohn Disease (CD), Colitis, Ulcerative (UC)
- Trial name
- BELIEVE (NCT03173144)
- Testing
- Primary exposure variable, Other (exploratory) exposure variables
- Where
- 3 sites in Denmark
- Volunteers
- 233 people
- Sponsor
- University of Southern Denmark
Alcoholic Liver Diseases, Decompensated Cirrhosis
Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease
Fibroscan is a non invasive imaging investigation which measures liver stiffness, known to correlate well with liver scarring and cirrhosis on liver biopsy.
- Trial name
- BANDED (NCT01701687)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Nottingham
Chronic Musculoskeletal Pain, Pain
Diagnostic and Prognostic Biomarkers for High-impact Chronic Pain: Development and Validation
To identify diagnostic and prognostic biomarker signatures of recovery versus having persisting high-impact chronic pain and functional disability in adults with Chronic Musculoskeletal Pain.
- Conditions
- Chronic Musculoskeletal Pain, Pain, Pain, Chronic, Joint Pain
- Trial name
- NCT04994249
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Stanford University
Kidney Disease, Kidney Transplantation
BIOmarkers Before and After Kidney Transplantation
In clinical nephrology, the search for urinary, blood and tissue biomarkers of specific kidney diseases is an important goal. In recent years, the use of these biomarkers has made it possible to diagnose many renal diseases that…
- Trial name
- PROBIOT (NCT06810258)
- Testing
- Blood sample during native kidney biopsy, Blood sample during renal graft biopsy, Urine sample during renal graft biopsy
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myeloid Leukemia
Study of the Predictive Marker FLT in Patients Suffering From AML
Positron emission tomography uses various radioactive tracers to measure the metabolic activity in a none-invasive way, and specially to follow the activity of the disease during the treatments.
- Trial name
- TEP-FLT-LMA (NCT01599429)
- Where
- Canada
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Alzheimer's Disease, Mild Cognitive Impairment
New Biomarker for Alzheimer's Disease Diagnostic
The aim of this study is to examine the relationship between plasma putative biomarkers for Alzheimer's disease (i.e. Ab40 amyloid and total Ab42 amyloid, free, bound, free/bound, truncated, sAPPα) and : the risk of conversion of…
- Trial name
- BALTAZAR (NCT01315639)
- Testing
- biomarkers, MRI and CSF
- Where
- France
- Volunteers
- 1,067 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
The Diagnostic and Prognostic Value of Presepsin in Sepsis
Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or…
- Trial name
- NCT06180265
- Testing
- presepsin, procalciton, endotoxin
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Foggia