Clinical trials: Prognostic Biomarkers
Neuroendocrine Tumors
Identification of Biomarker Profiles GEP-NEN Patients
Although gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) were considered for years as rare tumors, their incidences are increasing.
- Trial name
- NCT02838862
- Where
- 3 sites in Germany
- Volunteers
- 470 people
- Sponsor
- University Hospital Schleswig-Holstein
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis, HBP
Heparin Binding Protein as a Prognostic Biomarker of Sepsis Severity
the aim of the study is to correlate between the severity of sepsis and serum heparin binding protein in the patients admitted to ICU with sepsis., and detect its value as a prognostic biomarker in sepsis
- Trial name
- NCT05610020
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Ain Shams University
Renal Cell Carcinoma
Plasma Glycosaminoglycans as Diagnostic and Prognostic Biomarkers in Surgically Treated Renal Cell Carcinoma
In this study, the investigators profiled plasma glycosaminoglycans (GAGs) in a retrospective consecutive series of patients with a radiographic finding of renal mass referred to primary surgery for renal cell carcinoma (RCC).
- Trial name
- NCT03471897
- Testing
- Glycosaminoglycan plasma score
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Chalmers University of Technology
Cardiac Surgery, Disorder of Blood Gas
ΔvapCO2 / Cav02 Ratio as a Prognostic Marker and Predictor of Complications After Cardiac Surgery
This study evaluates the usefulness of the ΔvapCO2 / Cav02 ratio to predict complications after elective cardiac surgery, comparing it with others markers such as lactate, arteriovenous CO2 difference (ΔvapCO2) and would try to…
- Conditions
- Cardiac Surgery, Disorder of Blood Gas, Postoperative Complications, Shock
- Trial name
- NCT02876406
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital San Carlos, Madrid
Adenocarcinoma Esophagus, Adenocarcinoma of the Stomach
Molecular Analysis of Gastric and OEsophageal Cancers STudy
A prospective translational tissue collection study to identify biomarkers predictive of treatment response/resistance and biomarkers of prognostic value from a series of patients who are investigated for and diagnosed with early…
- Conditions
- Adenocarcinoma Esophagus, Adenocarcinoma of the Stomach, Adenocarcinoma - GEJ, Squamous Cell Car. - Esophagus
- Trial name
- MAGnET (NCT06702384)
- Testing
- biopsy
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Multiple Sclerosis
OFSEP Very High Definition Cohort
Multiple sclerosis (MS) is the most common acquired neurological disease leading to disability in young adults. MS often leads to the development of a physical and/or cognitive impairment that disables patients in their daily…
- Trial name
- VHD cohort (NCT05622643)
- Testing
- MRI
- Where
- 5 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- EDMUS Foundation
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline…
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT06561906
- Testing
- Multimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Chest Pain
Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients
Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized.
- Trial name
- dp/dt (NCT05416112)
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
Minor/Mild Traumatic Brain Injury
S100 Protein in Minor/Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is a Public Health problem, because of the numbers of events (more than 200,000 per year in France).
- Trial name
- S100 (NCT00822445)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PREDICTIVE BIOMARKERS, Evaluation of HPV-specific E5 Transcript Expression in a Cohort of Patients With HPV-associated OPC
New Prognostic and Predictive Biomarkers for HPV-associated Oropharyngeal Cancer
The study involves the coexistence of a retrospective part, in which a group of patients with HPV-associated OPC for whom follow-up data of at least 2 years after diagnosis are available, designed in order to evaluate the…
- Conditions
- PREDICTIVE BIOMARKERS, Evaluation of HPV-specific E5 Transcript Expression in a Cohort of Patients With HPV-associated OPC, HPV 16 Positive Oropharyngeal Tumors (OPC)
- Trial name
- NCT06097936
- Testing
- HPV-ASSOCIATED OROPHARYNGEAL CANCER
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Colon Adenocarcinoma, Stage I Colon Cancer
Postoperative Circulating Tumor DNA Monitoring in Stage I-III Driver-Mutant Colon Adenocarcinoma
This multicenter prospective observational cohort study will enroll 392 patients with stage I-III colon adenocarcinoma who undergo curative resection and whose tumors harbor at least one prespecified oncogenic driver mutation…
- Conditions
- Colon Adenocarcinoma, Stage I Colon Cancer, Stage II Colon Cancer, Stage III Colon Cancer
- Trial name
- ADX-DRIVER-CRC (NCT07795528)
- Testing
- Longitudinal ctDNA-MRD NGS testing at scheduled postoperative time points
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Ruijin Hospital
Heart Transplantation, End-stage Heart Failure
Donor Circadian Rhythm and Its Correlation With Prognosis After Heart Transplantation
The goal of this observational study is to learn about the impact of donor heart procurement time based on circadian rhythm on the long-term outcomes of heart transplant recipients.
- Conditions
- Heart Transplantation, End-stage Heart Failure, Circadian Rhythm
- Trial name
- CIRCA-HTx (NCT07301788)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lung Cancer (Diagnosis), Biomarkers / Blood
Circulating Immune Markers for Prognostic Evaluation in Postoperative Lung Cancer Patients
Investigating the Clinical Value of Tumor Antigen-Specific T Cells and Immune Cell Balance in Peripheral Blood of Non-Small Cell Lung Cancer Patients for Prognostic Evaluation.
- Trial name
- NCT07242482
- Testing
- Preoperative Peripheral Blood Immune Marker Analysis.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhao Jun
Nasopharyngeal Carcinoma
Prospective Study for Prognostic Biomarkers of Nasopharyngeal Carcinoma
The purpose of this clinical research project is to explore potential biomarkers and validate the predictive and prognostic value of molecular signature in nasopharyngeal carcinoma.
- Trial name
- NCT03025854
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Surgical Resection of the Colorectal Tumor
The Immunoscore as a Prognostic Marker for Patients With a Colorectal Cancer
Medical and Scientific Background: Colorectal cancers (CRC) are the leading cancers in both genders. This cancer is of prognostic severity. The prognosis of this cancer has not been significantly improved.
- Trial name
- IMMUCOL (NCT01688232)
- Where
- 6 sites in France
- Volunteers
- 459 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF)
Predicting Disease Progression in Atrial Fibrillation: A Multiparametric Approach for Prognostic Marker Identification and Personalized Patient Management
This project leverages artificial intelligence (AI) to decipher Atrial Fibrillation (AF) progression and optimize treatment strategies.
- Trial name
- PAMP FA (NCT06647914)
- Volunteers
- 322 people
- Sponsor
- IRCCS Policlinico S. Donato
Diabetic Nephropathy
Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy
Worldwide, the most common cause of chronic kidney disease (CKD) and end stage renal disease (ESRD) is diabetes. Unlike the past, in south korea, diabetes account for more than 40% of ESRD.
- Trial name
- NCT01673204
- Testing
- Calcitriol
- Where
- 2 sites in South Korea
- Volunteers
- 276 people
- Sponsor
- Seoul National University Hospital
Rectal Cancer Patients
Rectal Cancer CTC Trial
This prospective, multi-centre, randomised clinical trial aims to compare the effect of neoadjuvant chemoradiotherapy versus primary surgery on circulating tumor cells (CTCs) in patients with stage II-III rectal cancer without…
- Trial name
- NCT07194616
- Testing
- Primary Surgery, Neoadjuvant radiochemotherapy and surgery
- Where
- 4 sites in Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Prostate Cancer
Novel MRI Assessment of Prostate Cancer VALIDATE-PRO
For 50 years the diagnosis of prostate cancer has been with Prostate Specific Antigen (PSA) blood testing and prostate biopsy. However, this approach resulted in over-diagnosis, over-treatment and missed clinical important…
- Trial name
- VALIDATE-PRO (NCT05017181)
- Where
- United Kingdom
- Volunteers
- 234 people
- Sponsor
- University College, London