Clinical trials: Prognostic Biomarkers
Endometriosis
Diagnostic and Prognostic Markers of Endometriosis in Menstrual Blood
The goal of this observational study is to identify diagnostic and prognostic biomarkers for endometriosis using menstrual blood, an easily accessible yet overlooked biological fluid in women of reproductive age, affected or not…
- Trial name
- MultiMENDo (NCT06245512)
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hypertension, Pregnancy-Induced, HELLP Syndrome
PROTECT-Africa: Biomarker Validation for Preeclampsia Triage
Preeclampsia is a serious high blood pressure condition that can develop during pregnancy. It is one of the leading causes of death and illness for mothers and babies in Africa.
- Conditions
- Hypertension, Pregnancy-Induced, HELLP Syndrome, Eclampsia, Fetal Growth Retardation
- Trial name
- PROTECT-Africa (NCT07810439)
- Where
- Zimbabwe
- Volunteers
- 1,106 people
- Sponsor
- Africa Clinical Research Network (ACRN)
Carcinoma, Hepatocellular, Marker, Biological
MiRNA as a Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third leading cause of cancer-related death worldwide.
- Trial name
- NCT02448056
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Biomarker
Validation Study of a Serum-miRNA Signature in Glioma Patients.
Prospective, multicenter, noninterventional, nonprofit study of a cohort of patients with glioma, aimed at validating miRNA-serum signatures associated with IDH1 status and prognosis, as reliable, specific and sensitive…
- Trial name
- NCT06178692
- Testing
- Validation of miRNA-serum signatures associated with IDH1 status
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute
Diabetic Foot
Negative Pressure Wound Therapy in Diabetic Wounds
Topical Negative Pressure Wound Therapy (TNPW) is an established tool in the management of Diabetic foot ulcer in many countries. This treatment option is under utilized in the public sector of Mauritius.
- Trial name
- NCT05041244
- Testing
- Negative pressure wound therapy delivered through VAC, Standard of care
- Where
- Mauritius
- Volunteers
- 80 people
- Sponsor
- University of Mauritius
Multiple Sclerosis
Multiple Sclerosis: Chi3L1 and Treatment Efficacy
Chitinase 3-like 1 (Chi3L1) is a Human protein synthetized by inflammatory cells. Its serum level increases in case of autoimmune diseases, and especially during multiple sclerosis (MS).
- Trial name
- NCT04289675
- Testing
- Interferon-Beta
- Volunteers
- 63 people
- Sponsor
- Central Hospital, Nancy, France
Lung Adenocarcinoma, Breast Adenocarcinoma
Prognostic Value of the Marker P63 in Adenocarcinoma of Lung, Breast, and Pancreas
The p63 gene is a recently discovered member of the p53 family located at chromosome 3q27Many studies have reported that overexpression of p63 can mimic p53 activities by binding DNA, activating transcription, and inducing…
- Conditions
- Lung Adenocarcinoma, Breast Adenocarcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT01942629
- Testing
- their will be no intervention in any of the groups, the study is retrospective
- Volunteers
- 300 people
- Sponsor
- Rambam Health Care Campus
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Diabetes Mellitus, Diabetic Nephropathy
Role of Triglyceride-Glucose Index and Inflammatory Biomarkers as Prognostic Tools for Progression of Diabetic Nephropathy
This study aims to evaluate the prognostic value of the Triglyceride-Glucose (TyG) index alongside inflammatory biomarkers in predicting the progression of diabetic nephropathy, exploring their correlation with disease severity…
- Trial name
- NCT07813793
- Volunteers
- 105 people
- Sponsor
- Assiut University
Cervical Cancer, Recurrent Cervical Cancer
Circulating cfDNA and HPV as Prognostic Biomarkers for First-Line Recurrent Metastatic Cervical Cancer
Primary Objective of this study: To investigate the correlation between longitudinal quantitative dynamics of circulating tumor DNA (ctDNA) and HPV-derived cell-free DNA (HPV cfDNA) in peripheral blood and clinical prognosis…
- Conditions
- Cervical Cancer, Recurrent Cervical Cancer, Metastatic Cervical Cancer
- Trial name
- NCT07673211
- Testing
- Biospecimen collection (peripheral blood and paraffin tumor tissue)
- Volunteers
- 60 people
- Sponsor
- Zhejiang Cancer Hospital
Tuberculosis, Thoracic Surgery
Study of TB Lesions Obtained in Therapeutical Surgery
The correlation of the morphologic, microbiological, genetic and histopathological characteristics of TB lesions obtained in therapeutical surgery with the clinical forms and features of the patients will provide essential…
- Conditions
- Tuberculosis, Thoracic Surgery, Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant
- Trial name
- SH-TBL (NCT02715271)
- Testing
- therapeutical surgery for TB
- Where
- Georgia
- Volunteers
- 192 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Metastatic Non-small Cell Lung Cancer, Neoplasm
Body Composition and Inflammatory-Metabolic Indices in Immunotherapy-Treated Metastatic Non-Small Cell Lung Cancer: The SARC-CTI Study
This retrospective, single-center observational cohort study evaluates inflammatory-metabolic, cachexia-related, and computed tomography (CT)-derived body-composition markers in patients with metastatic non-small cell lung cancer…
- Trial name
- SARC-CTI (NCT07192926)
- Testing
- Immune Checkpoint Inhibitor-Based Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 155 people
- Sponsor
- Ankara Etlik City Hospital
Bell Palsy
Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults
Bell's palsy (idiopathic peripheral facial palsy) is the most common cause of facial palsy, which is related to the inflammation of the facial nerve, possibly induced by herpesvirus reactivation.
- Trial name
- BIOFIPS (NCT05582915)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Montpellier
Lung Transplant Rejection, Lung Transplant Failure
Diagnostic and Prognostic Biomarkers of Transplant Dysfunction in the Context of Lung Transplantation
Transplant results vary considerably from one organ to another. Lung transplantation has poorer long-term outcomes than other solid organ transplants, with a current median post-transplant survival of 6.0 years.
- Conditions
- Lung Transplant Rejection, Lung Transplant Failure, Lung Transplant; Complications, Lung Transplant Failure and Rejection
- Trial name
- DATACOL (NCT04837339)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Hopital Foch
Limbal Stem Cell Deficiency
ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
In this study the prognostic value of ABCB5 in survival of the limbal stem cell transplantation expanded in vitro on amniotic membrane for corneal surface reconstruction in patients with limbal stem cell deficiency will be…
- Trial name
- NCT02579993
- Testing
- Pannus and conjunctival dissection, Human cultivated limbal stem cell transplantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Cancer
Apparent Diffusion Coefficient as a Prognostic Biomarker in Cervical Cancer
This study aims to develop the technique of Diffusion-Weighted Magnetic Resonance Imaging(DW-MRI)for the assessment of stage 1 cervical cancers.
- Trial name
- NCT01937533
- Testing
- Magnetic Resonance Imaging using an endovaginal receiver coil
- Where
- United Kingdom
- Volunteers
- 236 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Histiocytosis, Langerhans-Cell
Biomarkers for Diagnostic, Prognostic and of Response to Treatment in Adult Langerhans Cell Histiocytosis
Adult Langerhans histiocytosis (LCH) is a rare disease of unknown etiology, characterized by the activation of the MAPK (Mitogen-activated protein kinases) pathway, driven by various somatic mutations in the specific lesions of…
- Trial name
- BIOHISTIO (NCT06197204)
- Testing
- Blood sampling, Biopsy
- Where
- France
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periampullary Adenocarcinoma, Periampullary Cancer
Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer
The CHAMP (Chemotherapy, Host response And Molecular dynamics in Periampullary cancer) study is a prospective, single-arm observational study that started Sept 1 2018.
- Conditions
- Periampullary Adenocarcinoma, Periampullary Cancer, Pancreatic Cancer
- Trial name
- CHAMP (NCT03724994)
- Testing
- Gemcitabine
- Where
- Sweden
- Volunteers
- 201 people
- Sponsor
- Lund University
Gonarthrosis, Serum Albumin Low
PROGNOSTIC ROLE OF SERUM ALBUMIN LEVEL IN RADIOLOGICAL PROGRESSION OF GONARTHROSIS: IS IT A BIOMARKER IN ITSELF? A BIOMARKER ASSOCIATED WITH SYSTEMIC INFLAMMATION?
The aim of our study is to evaluate the prognostic roles of serum albumin level and systemic inflammation-related indices, including and not including serum albumin level, in the radiological progression of gonarthrosis.
- Trial name
- NCT06159751
- Testing
- serum albumin level
- Where
- Turkey (Türkiye)
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Metastatic Pancreatic Cancer
Relationship Between Evolution of Resting Energy Expenditure and Tumoral Response to Chemotherapy in Patients Suffering From Pancreas Cancer
The purpose of this study is to determine whether evolution of resting energetic expenditure is a predictive marker of tumoral response for patients suffering from metastatic pancreatic cancer and treated with 1st line of…
- Trial name
- EnergiePancrea (NCT02921646)
- Testing
- Measure of resting energetic expenditure
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Center Eugene Marquis