Clinical trials: Prognostic Biomarkers
Systemic Sclerosis
Chest CT Biomarkers as Prognostic Predictors in SSc-ILD
The goal of this retrospective observational study is to investigate whether novel imaging biomarkers of airways, vessels, and overall extent of fibrosis at baseline predict ILD progression, vasculopathy development, and survival…
- Trial name
- NCT06472362
- Testing
- HRCT biomarkers
- Where
- 7 sites in France, Germany and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Breast Cancer
Relevance of T Lymphocytes Tumor Infiltrates CD8 and Foxp3 as Immune Prognostic Biomarker in Breast Cancer Treated by Neo Adjuvant Chemotherapy
Neoadjuvant chemotherapy is standard therapy for the management of localised breast cancer, and makes it possible to evaluate tumour response.
- Trial name
- PRIMUNEO (NCT01513408)
- Testing
- immunohistochemical detection of lymphocytes T CD8+/Foxp3 ratio
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Georges Francois Leclerc
Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
Biomarkers in Predicting Treatment Response in Samples From Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant Chemotherapy
This research trial studies biomarkers in predicting treatment response in samples from patients with early-stage non-small cell lung cancer previously treated with adjuvant chemotherapy.
- Conditions
- Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer
- Trial name
- NCT01595074
- Testing
- medical chart review, laboratory biomarker analysis
- Where
- Canada
- Volunteers
- 950 people
- Sponsor
- National Cancer Institute (NCI)
Critical Lower Limb Ischemia, Postoperative Complications
Impact of Nutritional and Inflammatory Status in Patients With Critical Limb-threatening Ischemia
The peripheral arterial disease (PAD) has been associated with all-cause and cardiovascular mortality. Despite minimally invasive endovascular techniques, patients with critical limb-threatening ischemia (CLTI) have a poor…
- Trial name
- NCT04756115
- Testing
- Vascular Surgery.
- Where
- Spain
- Volunteers
- 310 people
- Sponsor
- Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery
Mycosis Fungoides, Sezary Syndrome
Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome.
A translational study for identification of prognostic and treatment-predictive biomarkers in Mycosis fungoides and Sézary syndrome.
- Trial name
- BIO-MUSE (NCT04904146)
- Testing
- Blood tests and testing of analysis of the lymphoma microenvironment in skin, skin barrier and skin microbiology profile.
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Covid19, C-reactive Protein
Early Predictors of Prognostic Course in Patients With COVID-19 in Critical or Semi-intensive Area.
Although the recent literature is building a remarkable background to answer the many unknowns related to SARS-CoV-2 infection, it is absolutely necessary to finalize every clinical effort to collect data that may be useful, in a…
- Conditions
- Covid19, C-reactive Protein, Procalcitonin, D-dimer
- Trial name
- NCT04873388
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Turin, Italy
Leukemia
Studying Biomarkers in Cell Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01057290
- Testing
- gene expression analysis, protein expression analysis, fluorescence activated cell sorting
- Volunteers
- 75 people
- Sponsor
- Children's Oncology Group
Acute Heart Failure (AHF), Dyspnoea
Acute Heart Failure in Elderly Patients Admitted to the Emergency Department with Acute Dyspnea: a Multimarker Approach Prognostic Study
Background and Rationale: Acute dyspnea is a frequent presenting symptom in emergency departments (ED), with acute heart failure (AHF) being the most common cause leading to hospitalization in elderly patients.
- Trial name
- READ-MA-PRONO (NCT06692439)
- Volunteers
- 185 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sepsis
STUDY00015328: Sepsis Endotypes
Determine the utility of biomarkers measured in blood and body fluid (stool, saliva, tracheal aspirate) when combined with clinical data, for predicting sepsis phenotypes that are associated with poor clinical outcomes.
- Trial name
- NCT03146546
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Milton S. Hershey Medical Center
Breast Cancer
Extracellular Vesicles in Breast Cancer Patientsin Undergone Neoadjuvant Chemotherapy
Extracellular vesicles (EVs) are lipid bilayer-delimited particles, naturally released from the cells and mediators of intercellular cross-talk.
- Trial name
- NCT05831397
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Lung Cancer (NSCLC)
Application of Methylation Markers in Early Detection and MRD Monitoring of Lung Cancer
This study aims to evaluate the utility of combined plasma SHOX2 and PTGER4 gene methylation analysis as a dynamic biomarker for monitoring minimal residual disease (MRD) and predicting recurrence in postoperative non-small cell…
- Trial name
- NCT07257458
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Haidian Hospital
Lymphoma
Study of Biomarkers Using Tissue Samples From Older Patients With Diffuse Large B-Cell Lymphoma Treated With Combination Chemotherapy With or Without Rituximab on Clinical Trial ECOG-E4494
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors understand how patients respond to treatment.
- Trial name
- NCT00898157
- Testing
- laboratory biomarker analysis
- Volunteers
- 1,600 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Lupus Erythematosus
Study of the Role of Soluble Forms of RAGE (sRAGE/esRAGE) as Diagnostic and Prognostic Biomarkers of Systemic Lupus Erythematosus.
Systemic Lupus Erythematosus (SLE) is the most common systemic autoimmune disease. The clinical manifestations are severe and affect multiple target organs such as the kidney, central nervous system, skin, heart and joints.
- Trial name
- R-PA14098 (NCT02891213)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Pancreatic Neuroendocrine Tumor
Optimizing Risk Assessment Through cfDNA in Pancreatic Neuroendocrine Tumors for Clinical Evaluation
Non-functioning pancreatic neuroendocrine tumors (NF-PanNETs) are heterogeneous neoplasms of the pancreatic endocrine tissue, displaying variable clinical behavior from indolent to highly aggressive forms.
- Trial name
- ORACLE (NCT07817225)
- Testing
- cfDNA molecular profiling
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Massimo Falconi
Squamous Cell Carcinoma
Study the Expression of Annexin A1 and Its Potential Usage as a Prognostic Marker in Oral Cancer
Recent studies have shown that dysregulation of ANXA1 expression are associated with tumorigenesis. Overexpression of ANXA1 protein is found in a wide variety of human tumors, such as breast 10, liver 11, pancreatic cancer14 and…
- Trial name
- NCT00364715
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
CT Scans Prior to Surgery With a Least 2 Years of Follow-up
Identification of Image Phenotypes to Predict Recurrence After Resection of Hepatocellular Carcinoma
Tumor recurrence, which occurs in 70% of patients with HCC within 5 years after hepatic resection, is a major cause of post-resection-death.
- Trial name
- LIVERIBIOPSY (NCT05235490)
- Testing
- Non intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
ACOD1 as a Prognostic Marker for Sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, with high morbidity and mortality worldwide. Reliable biomarkers are needed for early risk stratification and outcome prediction.
- Trial name
- NCT07533994
- Testing
- Blood draw for lab testing.
- Where
- 2 sites in China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Heart Failure
Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients
Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on…
- Trial name
- NCT01113866
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- University of Parma
Systemic Sclerosis, Inflammatory Myopathies
Search for Diagnostic and Prognostic Biomarkers in Systemic Sclerosis and Inflammatory Myopathies
Systemic sclerosis and inflammatory myopathies, which sometimes combine (scleromyositis), have shared pathophysiological elements.
- Trial name
- SCLEROMYOMICS (NCT04917705)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Strasbourg, France
Intracerebral Hemorrhage (ICH)
Improving the Prognosis for Cerebral Hemorrhage A Study of Clinical, Biological, and Imaging Markers
This study will establish a prospective, multicenter national cohort of patients with spontaneous intracerebral hemorrhage (ICH).
- Trial name
- TIPITCH (NCT07444853)
- Where
- 4 sites in France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Tours