Clinical trials: Prognostic Biomarkers
Heart Failure
Prognostic Value Of Short-Term Follow-up Biomarkers After Discharge In hOspitalized Patients With Acute Heart Failure
Several surrogate biomarkers including natriuretic peptide(NP), and growth differentiation factor-15(GDF-15) and ST2 has prognostic significance in heart failure(HF), and reductions in its value may predict clinical improvement.
- Trial name
- POSTBIO-HF (NCT04437628)
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Wonju Severance Christian Hospital
Ovarian Cancer
Systemic Inflammatory Biomarkers in Ovarian Cancer
In cancer patients, prognostic markers are needed to improve the management and clinical course of both the cancer itself and surgery therefor.
- Trial name
- NCT06629831
- Testing
- group with complications, group without complications
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Advanced Prostate Cancer, Castration Resistant
PRORADIUM: Prospective Multi-centre Study of Prognostic Factors in mCRPC Patients Treated With Radium-223.
PRORADIUM is a prospective multicentre observational study in metastatic Castration-Resistant Prostate Cancer (mCRPC), designed to explore prognostic biomarkers in patients undergoing treatment with radium-223.
- Conditions
- Advanced Prostate Cancer, Castration Resistant, Radium 223
- Trial name
- PRORADIUM (NCT02925702)
- Testing
- Radium 223 55mBq/Kg every 4 weeks intravenously
- Where
- 63 sites in Spain
- Volunteers
- 161 people
- Sponsor
- Centro Nacional de Investigaciones Oncologicas CARLOS III
Rheumatoid Arthritis, Arthralgia
Survivin as Predictive Biomarker for RA
Purpose: to examine the possibility of using the onco-protein survivin as a predictive biomarker for identifying individuals at risk of developing rheumatoid arthritis within a cohort of patients seeking treatment for joint…
- Conditions
- Rheumatoid Arthritis, Arthralgia, Joint Pain
- Trial name
- SurviPred (NCT03444623)
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Vastra Gotaland Region
Prostate Cancer
Prostate Stereotactic Radiation and Radio-induced Lymphocyte Apoptosis for Predicting Late Toxicities in Prostate Cancer (PROSTERA)
This monocentric interventional study investigates whether the Radio-induced Lymphocyte Apoptosis (RILA) assay can predict the occurrence of late radiation-induced toxicities in patients with localized prostate cancer treated…
- Trial name
- PROSTERA (NCT07145437)
- Testing
- Radio-induced Lymphocyte Apoptosis (RILA) Assay, Stereotactic body radiotherapy (SBRT)
- Volunteers
- 220 people
- Sponsor
- Clinique Sainte Clotilde
Possibility of Using microRNA30a as a Prognostic Marker in Philadelphia Positive Leukemic Patients by Measure Level of microRNA30a in Blood Sample
Value of MicroRNA30a in Philadelphia Positive Leukemic Patients
The Philadelphia chromosome in leukemogenesis:The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as (Ph) and is a hallmark of (CML).
- Trial name
- NCT05112653
- Volunteers
- 70 people
- Sponsor
- Assiut University
Advanced Prostate Cancer, Cabazitaxel
PROSTAC: Prospective Multi-centre Study of Prognostic Factors in mCRPC Patients Treated With Docetaxel or Cabazitaxel.
PROSTAC is a prospective multicentre observational study in metastatic Castration-Resistant Prostate Cancer (mCRPC), designed to explore prognostic biomarkers in patients undergoing treatment with docetaxel or cabazitaxel
- Conditions
- Advanced Prostate Cancer, Cabazitaxel, Docetaxel
- Trial name
- PROSTAC (NCT02362620)
- Where
- 25 sites in Spain
- Volunteers
- 402 people
- Sponsor
- Centro Nacional de Investigaciones Oncologicas CARLOS III
Pulpitis - Irreversible
Prognostic Biomarkers for Pulpotomy Outcome
This study will recruit 180 molars diagnosed with irreversible pulpitis. Full pulpotomy will be performed on 120 teeth, while RCT (root canal treatment) will be conducted on another cohort of 60 teeth as the control for assessing…
- Trial name
- NCT06514053
- Testing
- Full pulpotomy, Root canal treatment
- Where
- Hong Kong
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Acute Kidney Injury
Identification of Prognostic Urinary Biomarker for Acute Kidney Injury in Preterm Infants by Proteomics
Clinical definitions of acute kidney injury (AKI) have been based on an increase in serum creatinine and a decrease in urine output.
- Trial name
- NCT02743273
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Seoul National University Hospital
Psoriatic Arthritis, Psoriasis
Ultrasound Enthesitis Response in Psoriatic Arthritis
The aim of this observational study will be to recruit 100 Psoriatic Arthritis (PsA) patients beginning on their biologic therapy and asses, both clinically and with the use of ultrasound (US), how enthesitis responds to biologic…
- Conditions
- Psoriatic Arthritis, Psoriasis, Enthesitis
- Trial name
- NCT03955861
- Testing
- adalimumab, Certolizumab, Etanercept
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Belfast Health and Social Care Trust
Chronic Coronary Syndrome
Role of Tryptase Levels in Patients With Stable Coronary Artery Disease.
The aim of this study is to measure the levels of serum tryptase and correlate them with the severity of coronary artery disease in study population.
- Trial name
- TRY-CAD (NCT06958016)
- Where
- 2 sites in Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Pulmonary Disease, Chronic Obstructive
The Cohort Study for Chronic Obstructive Pulmonary Disease (COPD) in China
The purpose of this study is to establish the large COPD cohort and biological database in China, aiming for precision medicine to optimize diagnosis and treatment choices and to monitor and improve clinical outcomes in this…
- Trial name
- NCT03044847
- Testing
- COPD group
- Where
- China
- Volunteers
- 3,800 people
- Sponsor
- Beijing Chao Yang Hospital
Ovarian Cancer
Screening and Identification of Ovarian Cancers
Ovarian cancer is the first mortality rate of gynecologic malignancies. The incidence of ovarian cancer increased in recent 10 years and it has become the ninth cause of malignancies in the women in Taiwan.
- Trial name
- NCT00854399
- Testing
- Staging surgery or debulking surgery
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Pseudomyxoma Peritonei, Colorectal Carcinoma
Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies
The aim of this study is to identify biomarkers of disease recurrence and prognosis to optimize patient selection for treatment with cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), and through…
- Conditions
- Pseudomyxoma Peritonei, Colorectal Carcinoma, Ovarian Carcinoma, Mesothelioma
- Trial name
- PSM (NCT02073500)
- Testing
- Observational study.
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Pulmonary Embolism
Prognostic Value of Heart-type Fatty Acid-Binding Protein (h-FABP) in Acute Pulmonary Embolism
The patients presenting with acute pulmonary embolism and right ventricular dysfunction are at high risk for life-threatening events and must be identified in the emergency department for adequate care and hospital admission.
- Trial name
- NCT01326507
- Testing
- Dosage de l'h-FABP
- Where
- France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Toulouse
Cardiac Surgery
Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery
To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.
- Trial name
- NCT00416299
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Klinikum Ludwigshafen
Metastatic Non-small Cell Lung Cancer
Pilot Study of the Contribution of Fractional Exhaled Nitric Oxide as a Prognostic Marker of Response to Anti-PD-L1 Immunotherapy in Non-small Cell Lung Cancer
Based on the use of the patient's natural defences, immunotherapy mobilizes the immune system to recognize and destroy cancer cells, and it has revolutionized the treatment of lung cancer.
- Trial name
- FENOTYPE (NCT05985330)
- Testing
- Measurement of FeNO
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Aortic Stenosis
Myocardial Efficiency of the Left Ventricle in Asymptomatic Patients With Aortic Valve Stenosis - a Prognostic Marker and a Target for Intervention?
Background - Aortic valve stenosis (AS) is the most common heart valve disease among adults in the Western world with a prevalence of 3 % in people older than 75 years of age.
- Trial name
- MELVAS (NCT02076711)
- Testing
- Metoprololsuccinate
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
Preeclampsia (PE), Hypertensive Disorder of Pregnancy
Endothelial Dysfunction for Prognosis In Patients With preeClampSia
Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus.
- Trial name
- EPICS (NCT06912477)
- Testing
- Hyperspectral imaging, Further markers of endothelial dysfunction
- Where
- Germany
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Leukemia
Prognostic Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood or tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01245231
- Testing
- protein expression analysis, western blotting, flow cytometry
- Volunteers
- 150 people
- Sponsor
- Children's Oncology Group