Clinical trials: Prognostic Biomarkers
Arterial Calcification, Kidney Failure
Vascular Calcifications in Kidney Transplant Recipient
Kidney transplant candidates undergo extensive diagnostic evaluation aimed at assessing their cardiovascular (CV) risk, which remains the leading cause of disability and death in this patient population.
- Conditions
- Arterial Calcification, Kidney Failure, Kidney Transplant; Complications
- Trial name
- NCT05697458
- Testing
- computerized tomography scanning
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- Clinical Hospital Center Rijeka
Proteomics, Pancreatic Cancer
Prognostic Biomarkers of Pancreatic Cancer Based on Proteomic Techniques
Sequence I (Retrospective study: proteomic analysis of pathological specimens and information collection of previous patients with pancreatic cancer) Sequence 2 (Non-interventional prospective study, sample and information…
- Conditions
- Proteomics, Pancreatic Cancer, Prognostic Biomarkers
- Trial name
- NCT05289895
- Testing
- No intervention
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Platelet Distribution Width, Mean Platelet Volume
Early Platelet Indices as Biomarkers of Deep Vein Thrombosis and Prognostic Markers in Mechanically Ventilated ICU Patients
This prospective observational study aims to evaluate the role of mean platelet volume (MPV) and platelet distribution width (PDW) as early indicators of deep vein thrombosis (DVT) and as prognostic markers in mechanically…
- Trial name
- NCT07197333
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cardiac Surgery Associated - Acute Kidney Injury, Critical Illness
Prognostic Value of Metabolic Characteristics in High-Risk Populations for Acute Kidney Injury After Cardiac Surgery
This project aims to explore the metabolic characteristics of adverse renal outcomes in high-risk populations after cardiac surgery by using multi-omics techniques, in order to understand the metabolic changes in patients during…
- Trial name
- NCT07521787
- Testing
- Standard care "bundle"
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shanghai Zhongshan Hospital
Vasorin, Septic Shock
Diagnostic and Prognostic Evaluation of Vasorin During Septic Shock
Septic shock is the most severe form of infection. Currently, an early specific biomarker for septic shock is needed. Remember that shock situations are numerous, not only septic (eg hemorrhagic, cardiogenic...), and also…
- Conditions
- Vasorin, Septic Shock, Shock, Biomarker
- Trial name
- VASO-DIAG (NCT07203833)
- Testing
- blood sample
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Diabetic Retinopathy
Role of the Serum Exosomal miRNA in Diabetic Retinopathy (DR)
Diabetic retinopathy (DR) is one of the most common causes of blindness worldwide. It is a progressive disease and its detection in early phases is very crucial for visional outcomes.
- Trial name
- NCT03264976
- Testing
- hematological examination, ophthalmic examination
- Volunteers
- 200 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Mild Cognitive Impairment
Mild Cognitive Impairment, Use of qEEG as a Prognostic Marker
Multi center study of six Memory Clinics in four Nordic countries in validating a prognostic diagnostic investigation of qEEG in Mild Cognitive Impairment (MCI).
- Trial name
- NCT03659643
- Testing
- EEG with SPR analysis
- Where
- Iceland
- Volunteers
- 300 people
- Sponsor
- Jon Snaedal
Dengue Hemorrhagic Fever, Dengue Shock Syndrome
Prospective Study for the Evaluation of Dengue Prognostic Biomarkers in Singapore
World Health Organisation (WHO) has identified Dengue as the fastest spreading mosquito-borne disease in the world. This study follows on from the National Medical Research Council STOP Dengue Translational and Clinical Research…
- Conditions
- Dengue Hemorrhagic Fever, Dengue Shock Syndrome, Severe Dengue
- Trial name
- NCT04048837
- Where
- 3 sites in Singapore
- Volunteers
- 200 people
- Sponsor
- National University Hospital, Singapore
Prostate Cancer Metastatic
Expression of Molecular Markers in Circulating Tumor Cells of Metastatic Castration-Resistant Prostate Cancer
As prostate cancer progresses into castration-resistant stage from initial hormone-sensitive status, the biological behavior of tumor cells that dissociated from primary lesions changed.
- Trial name
- NCT03089099
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Urothelial Carcinoma Bladder
JAM3 as a Prognostic Biomarker in Muscle-Invasive Urothelial Carcinoma: Correlation With Therapeutic Response, and Survival Outcomes
Bladder cancer(BC) is the 10th most common cancer globally, with a higher incidence in males than females, being the 6th most common cancer in men with high mortality, causing a societal burden worldwide.
- Trial name
- NCT06901934
- Testing
- junctional adhesion molecule3 expression by immunhistochemistry
- Volunteers
- 40 people
- Sponsor
- Zeinab Yahia Zaki
Neuroendocrine Neoplasm, Adenocarcinoma
YOUNg Adults With Gastro-inteSTinal (GI) and nEuroendocrine canceRs.
The objective of the study is to create a common and unique platform for the acquisition of biological samples and, subsequently, the possible identification of predictive and prognostic biomarkers for young adults with…
- Trial name
- YOUNGSTER (NCT06337760)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- European Institute of Oncology
Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation
Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)
Chronic graft-versus-host disease (cGvHD) is one of the most serious complications following BMT (Bone Marrow Transplantation). cGvHD occurs when donor immune cells "attack" the tissues and organs of the person receiving the BMT.
- Conditions
- Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Blood Cancer
- Trial name
- NCT05692713
- Where
- 10 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of British Columbia
Odontogenic Cysts, Odontogenic Tumors
Evaluation of the Expression and Prognostic Role of Tumor Stem Cell Marker SOX2 in Odontogenic Cysts and Tumors
The pathogenesis of odontogenic lesions remains unclear; however, a probable explanation may involve the existence of tumor stem cells (TSCs), which are thought to generate both benign and malignant tumors.
- Trial name
- NCT06833840
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Telomere Length in Healthy Controls
Telomeres and T-cell Receptor Excision Circles (TRECs) From Peripheral Blood in Normal Subjects Over Time
The Investigators have established a cohort of patients with recent-onset inflammatory arthritis called Early Undifferentiated PolyArthritis (EUPA). This cohort was established to define novel biomarkers of poor outcomes.
- Trial name
- NCT01982890
- Testing
- Control
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Lymphoma
S8809-S9800-S9911TM- Biological Markers in Patients With Follicular Lymphoma Treated on Clinical Trial SWOG-8809, SWOG-9800, or SWOG-9911
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment.
- Trial name
- NCT00896922
- Testing
- microarray analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Volunteers
- 180 people
- Sponsor
- SWOG Cancer Research Network
Acute Kidney Injury, Coronary Artery Disease
Renal Doppler Indices for Predicting Acute Kidney Injury After Isolated CABG
Acute kidney injury can occur after coronary artery bypass grafting (CABG). This prospective, single-center observational study will evaluate whether two measurements obtained from renal Doppler ultrasound-the renal augmented…
- Trial name
- NCT07821983
- Testing
- Renal Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Acute Coronary Syndromes
Prognostic Value of Biomarkers Associated With Endothelial Progenitor Cells Mobilization in Acute Coronary Syndromes
This prospective study aimed to validate a new prognostic approach of endothelial progenitor cells associated biomarkers in patients with acute coronary syndromes .
- Trial name
- NCT02117037
- Testing
- blood sample
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diabetic Ketoacidosis
Role of CBC as a Prognostic Marker for DKA Patients
1. To evaluate that change of platelet-to-lymphocyte Ratio affect the duration of hospital stay and mortality rate of DKA patients 2.
- Trial name
- NCT05666895
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body.
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Positive
- Trial name
- NCT03723928
- Testing
- Usual care disease monitoring, Serum Tumor Marker directed disease monitoring, Quality-of-Life Assessment
- Where
- 723 sites in United States, Guam and 1 more
- Volunteers
- 739 people
- Sponsor
- SWOG Cancer Research Network
Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission
Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study
The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU…
- Conditions
- Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission, Return of Spontaneous Circulation, Comatose
- Trial name
- CINEFIL (NCT07760636)
- Testing
- Value of neurofilament light chain (NFL) at different time points
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris