Clinical trials: Prognostic Biomarkers
Carcinoma, Squamous Cell, Carcinoma, Squamous
Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma
The study will utilize both retrospective and prospective data collection from patients that already had a bronchoscopy and lung resection or will have a bronchoscopy and lung resection for squamous cell carcinoma.
- Conditions
- Carcinoma, Squamous Cell, Carcinoma, Squamous, Squamous Cell Carcinoma, Lung Neoplasms
- Trial name
- NCT02549638
- Testing
- DNA Extraction
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Melanoma, Non Small Cell Lung Cancer
Exploratory Interventional Study of Prognostic Serum Biomarkers of Cancer Progression
Exploratory interventional study of prognostic serum biomarkers of cancer progression. Study of the relationship between the blood levels of soluble PDL1 and β2-microglobulin, and the clinical course of a metastatic solid tumor…
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Renal Cancer
- Trial name
- Onco-PDL1s/B2M (NCT05426317)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Drug-induced Liver Injury
A Prognostic Model for Drug-induced Liver Injury in China
A prospective, multi-center, non-interventional cohort study is going to conduct to explore the clinical characteristics, culprit drug(s) or herb(s), outcomes and risk factors of Drug-induced liver injury (DILI) in China and…
- Trial name
- DILI-PM (NCT05060289)
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Disorders of Consciousness Due to Severe Brain Injury
Peripheral Nerve Stimulation for Prognostic and Diagnostic Biomarker Identification in Disorders of Consciousness
This observational study aims to integrate anamnestic, clinical, and innovative neurophysiological data to assess their impact on the diagnosis and prognosis of patients with Disorders of Consciousness.
- Trial name
- MICRO-DOC (NCT06845800)
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Endometrial Adenocarcinoma, Recurrent Uterine Corpus Carcinoma
Prognostic Biomarkers in Patients With Endometrial Cancer
This research study is studying prognostic biomarkers in tissue samples from patients with endometrial cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that…
- Conditions
- Endometrial Adenocarcinoma, Recurrent Uterine Corpus Carcinoma, Stage I Uterine Corpus Cancer, Stage II Uterine Corpus Cancer
- Trial name
- NCT01208467
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 2,824 people
- Sponsor
- Gynecologic Oncology Group
Hepatocellular Carcinoma
Immune Cells as a New Biomarker of Response in Patients Treated by Immunotherapy for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Treatment options for advanced HCC remain very limited.
- Trial name
- IMMUNOCELL (NCT05044676)
- Testing
- patients with hepatocellular carcinoma
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Cancer
Tissue Microarrays (TMAs) Construction in Lung Cancer Samples
Construction of a large cohort of lung cancer patients to evaluate the Prognostic and Predictive Significance of the molecular biomarkers Epidermal growth factor receptor (EGFR), KRAS, Anaplastic lymphoma kinase (EML4-ALK)…
- Trial name
- LUNGTMA (NCT03136523)
- Where
- Greece
- Volunteers
- 324 people
- Sponsor
- Kostas N.Syrigos
Bladder Cancer
Prognostic Biomarkers in Patients With Urothelial Carcinoma
Bladder cancer (BC) is a heterogeneous malignancy with dismal outcome.Despite treatment, the 5-year overall survival rates for MIBC are <50%, with many patients unresponsive or inapt, necessitating biomarkers to select those most…
- Trial name
- NCT04872036
- Volunteers
- 66 people
- Sponsor
- Hellenic Cooperative Oncology Group
Prostate Cancer Metastatic
BAseLine TEstosterone as a Prognostic and/or Predictive bioMARKer in mHSPC
Despite large amounts of basic-science data supporting a role for androgens in PCa pathogenesis, there are conflicting clinical data on the role of endogenous testosterone in human de novo PCa pathogenesis.
- Trial name
- NCT05530395
- Testing
- Testosterone levels
- Where
- 3 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Ignacio Puche Sanz
Influenza
Biomarkers for the Prognosis of Influenza in Children
Context: Seasonal influenza affects 2.5 to 3 million people each year in France, resulting in 1500 to 2000 severe cases seen in intensive care units.
- Trial name
- BMIG (NCT03231995)
- Testing
- Collection of nasopharyngeal specimen collected at D0, D1, D2 and D5.
- Where
- 2 sites in France
- Volunteers
- 145 people
- Sponsor
- Hospices Civils de Lyon
CMT, CMT (Charcot Marie Tooth Disease)
A Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)
The most common inherited neuropathy is Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication of the gene expressing PMP22.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), CMT - Charcot-Marie-Tooth Disease, CMT1A
- Trial name
- CMT-MODs (NCT07476365)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
MTBI - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Rapid Diagnosis and Prognosis Recognition of Imaging and Biomarkers in Mild to Moderate Traumatic Brain Injury
The investigators will carry out multi-center and large sample research based on the Chinese population, screen the optimal diagnostic and prognosis recognition biomarkers and analyze the diagnostic critical cutoff values in…
- Trial name
- NCT05108909
- Testing
- MRI, CT, and serum biomarkers
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Pneumonia, Bacterial, Viral Infection
Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia
Clinical pneumonia is a leading cause of pediatric hospitalization. The etiology is generally bacterial or viral. Prompt and optimal treatment of pneumonia is critical to reduce mortality.
- Conditions
- Pneumonia, Bacterial, Viral Infection, Clinical Pneumonia, Plasmodium Falciparum Malaria
- Trial name
- NCT03996967
- Where
- 3 sites in United States, Netherlands and 1 more
- Volunteers
- 837 people
- Sponsor
- Boston University
Adrenal Gland Neoplasms
Evaluation of Molecular Markers in Adrenal Tumors
Background: Tumors of the adrenal gland are common. Most of them are not cancerous. However, there are no tests that can accurately tell which adrenal tumors are cancerous and which are not.
- Trial name
- NCT01348698
- Testing
- Tumor tissue biopsy, Surgery
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- National Cancer Institute (NCI)
Acute Pancreatitis
Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis
Acute pancreatitis (AP) is a potentially life-threatening disease with varying severity of presentation. Nearly 60%-80% of all cases of AP in developed countries are attributable to either gallstone disease or alcohol abuse.
- Trial name
- NCT03830060
- Testing
- Measurement of cortisol
- Volunteers
- 50 people
- Sponsor
- Assiut University
Subjects With p16 Positive/HPV Positive Squamous Cell Carcinomas of the Oropharynx
HPV Serum DNA Levels Predicting Outcome in p16+ Squamous Cell Head and Neck Cancer
To assess in an exploratory manner, the pronostic utility for locoregional control, progression-free and distant metastasis-free survival of a pre-therapy and post-therapy blood DNA test of HPV E6 and E7 DNA for subtypes 16 and…
- Trial name
- NCT01984359
- Testing
- Obtaining Human tissue
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung Cancer
Biomarkers in Predicting Response in Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant Chemotherapy
This research trial studies prognostic and predictive markers in patients with early stage non-small cell lung cancer receiving chemotherapy.
- Trial name
- NCT01294280
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Coronary Syndrome
RNA as Prognostic Biomarkers in Patients With Acute Coronary Syndrome
Identify circulating protein-coding (mRNAs) or non-coding (ncRNAs) transcripts (ACS_signature) predictive of ventricular dysfunction in ACS patients undergoing PCI.
- Trial name
- RNAacs (NCT06058182)
- Testing
- blood draws
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS Policlinico S. Donato
Locally Advanced Cervical Cancer, Prognostic Biomarker
Evaluation of Persistent Infection by Oncogenic Human Papillomavirus (HPV) in Patients Treated for Cervical Carcinoma and Its Relation to Prognostic Factors
Cervical cancer is strongly associated with HPV infection, yet current post-treatment follow-up relies on cytology and imaging, which have limited accuracy, particularly after radiotherapy.
- Trial name
- ANIHTA (NCT07600515)
- Volunteers
- 100 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo