Clinical trials: Prognostic Biomarkers
COVID - 19, Prognosis
The Prognostic Role of Red Blood Cell Distribution (RDW) in Severe COVID-19 Patients
The aim of this study was to evaluate the prognostic significance of erythrocyte distribution width (RDW) in severe and critically ill COVID-19 patients followed in the intensive care unit (ICU).
- Conditions
- COVID - 19, Prognosis, ICU
- Trial name
- RDW-Covıd-19 (NCT07244731)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Ankara University
Cutaneous Melanoma
Expression of IL4 Induced Gene 1 in Patients With Cutaneous Melanoma: Value in Prognosis and/or in Predictive Response to Immune Checkpoint Inhibitors
To characterize and quantify immune cells expressing the Interleukine 4 induced gene 1 (IL4I1) immunosuppressive enzyme in the blood and in tissue of melanoma patients (primary tumor, sentinel lymph nodes and cutaneous…
- Trial name
- ENZYMELA (NCT04253080)
- Testing
- Blood sample, Cutaneous melanoma biopsy
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Phase Biomarkers, Medical ICU Admitted Patients
MR-proADM and CT-proET-1 During ICU Treatment
This pilot-study will be a prospective, single-centre, observational study including 100 critically ill patients consecutively admitted to the medical intensive care unit (ICU) of the University hospital of Zurich, Switzerland…
- Trial name
- MR-proADM (NCT03651635)
- Testing
- Blood sampling for MR-proADM & CT-proET-1
- Where
- Switzerland
- Volunteers
- 533 people
- Sponsor
- University of Zurich
Parkinson Disease
Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease
Observational, prospective, monocentric study to assess clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients and rate of progression compared to healthy controls (HC) and subjects at risk to…
- Trial name
- ICEBERG (NCT02305147)
- Testing
- Clinical, biological and imaging followup
- Where
- France
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pulmonary Disease, Chronic Obstructive
Nutritional Status in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
A cross sectional observation study of body composition in COPD patients consecutively hospitalized with acute exacerbation.
- Trial name
- NCT03709498
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Evangelismos Hospital
Triple Negative Breast Neoplasms, Triple Negative Breast Cancer
Triple-negative Breast Cancer: a New Perspective on Biomarkers
A single-institutional cohort to determine the prevalence of new immunohistochemical panel in advanced triple-negative submitted to neoadjuvant chemotherapy and its association with response and survival.
- Trial name
- TNBCbrazil (NCT03539965)
- Where
- Brazil
- Volunteers
- 239 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Advanced Heart Failure, Cardiorenal Syndrome
Cardiorenal Syndrome: Characteristics and Prognostic Impact in Advanced Heart Failure
Advanced heart failure (AHF) represents the end stage of chronic heart failure with reduced ejection fraction and affects up to 10% of patients with heart failure.
- Trial name
- CARAVEL (NCT07666516)
- Testing
- Cardiorenal syndrome follow-up
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Bladder Cancer
Tumorspecific T-cell Immunity in Bladder Cancer as Prognostic Marker
Bladder cancer is generally susceptible to immunotherapeutic measures. The investigators will characterize 40 patients with muscle-invasive bladder cancer regarding the existence and frequency of tumorspecific T-cells and…
- Trial name
- NCT01198808
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Breast Cancer
Breast Cancer, Omics, and Precision Medicine
The standard tissue biopsy strategy for cancer detection is not comprehensive enough to profile the whole epi-genomic signatures of breast cancer (BC) and ensure an accurate prognosis and prediction of drug response.
- Trial name
- BR(E)2ASTOME (NCT04996836)
- Testing
- Next Generation Sequencing and Network Analysis
- Volunteers
- 200 people
- Sponsor
- University of Campania Luigi Vanvitelli
Pancreatic Ductal Adenocarcinoma (PDAC)
RPSA as a Potential Prognostic Biomarker of Pancreatic Cancer
PDAC (Pancreatic ductal adenocarcinoma) represents 90% of pancreatic tumors. The prognosis of PDAC remains poor at this time. Its management is based on surgery for early stages, associated with neoadjuvant and adjuvant…
- Trial name
- PaCaBioMarkeR (NCT04575363)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 90 people
- Sponsor
- CHU de Reims
Head and Neck Cancer
PA.RI.GE. Study. The Prognostic Role of Inflammatory Circulating Biomarkers in HNSCC: a Prospective Multicentric Trial
This is a clinical, observational, non-pharmacological, multicenter, prospective case-control no-profit study to assess the prognostic role of several circulating inflammatory biomarkers
- Trial name
- NCT06809673
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Ospedale Policlinico San Martino
Pulmonary Embolism
Prognostic Model for Long-Term Cardiac Function After Pulmonary Embolism Based on Dynamic Electrocardial Signal and Circulating Biomarkers
Pulmonary embolism (PE) is a highly morbid and fatal cardiovascular disease. Right ventricular dysfunction (RVD) secondary to PE indicates a poor prognosis and serves as a critical basis for risk stratification.
- Trial name
- NCT06541353
- Where
- China
- Volunteers
- 500 people
- Sponsor
- China-Japan Friendship Hospital
Stroke, Transient Ischemic Attack
The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)
Sodium imbalance is common and an adverse prognostic factor in hospitalized patients. However, identifying the causes of sodium imbalance is challenging in clinical practice.
- Trial name
- NCT00390962
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- University Hospital, Basel, Switzerland
Lung Cancer
The Prognostic and Predictive Value of the CA-125 Marker in Lung Cancer Monitoring
The tumor associated CA-125antigen for diagnosis and follow-up of ovarian cancer was well defined. Increased serum CA125 level may have many diagnoses other than ovarian cancer, including breast, colorectal and lung cancer.
- Trial name
- NCT02437760
- Testing
- serum and pleural effusion CA-125 level
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- E-DA Hospital
Thyroid Cancer
Anaplastic Thyroid Cancer and Follicular Thyroid Cancer-derived Exosomal Analysis Via Treatment of Lovastatin and Vildagliptin and Pilot Prognostic Study Via Urine Exosomal Biological Markers in Thyroid Cancer Patients
The investigators expected to enroll 30 patients with papillary, follicular or anaplastic thyroid cancer, and collect their urine samples before operation, immediately after operation, post-operative 3, 6 12 months.
- Trial name
- NCT02862470
- Volunteers
- 22 people
- Sponsor
- National Taiwan University Hospital
Acute Pyelonephritis
Accuracy of Infection Biomarkers in the Investigation of Patients With Suspected Acute Pyelonephritis
The aim of this study is to investigate the diagnostic and prognostic value of C-reactive protein (CRP), serum procalcitonin (PCT) and soluble urokinase plasminogen activator receptor (suPAR) in the initial investigation of…
- Trial name
- NCT04686318
- Testing
- Biomarkers for acute pyelonephritis
- Where
- Denmark
- Volunteers
- 229 people
- Sponsor
- University of Southern Denmark
Sepsis
Biomarkers for the Early Identification of Sepsis in the Emergency Department
Monocentric prospective study on consecutive patients attending the emergency department and suspected to have sepsis. Blood sampling for the measurement of a panel of biomarkers of interest in sepsis.
- Trial name
- BIPS (NCT02707718)
- Testing
- blood sampling
- Where
- 2 sites in France
- Volunteers
- 320 people
- Sponsor
- Pitié-Salpêtrière Hospital
Dementia, Alzheimer Disease
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease…
- Conditions
- Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- CRND TorCA (NCT06529744)
- Where
- 4 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Ovarian Cancer, Borderline Ovarian Tumors
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA.
- Conditions
- Ovarian Cancer, Borderline Ovarian Tumors, Benign Ovarian Tumor, Unexplained Infertility
- Trial name
- NCT03779399
- Testing
- Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Liver Metastases From Colorectal Cancer (mCRC)
Radiomics of Colorectal Liver Metastases: Identification of New Prognostic Biomarkers.
Background: Liver metastases (CLM) affect about half of patients with colorectal cancer and dictate patients' prognosis. Prediction of prognosis is of paramount importance for patients allocation to the most adequate treatment…
- Trial name
- NCT06779734
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas