Clinical trials: Prognostic Biomarkers
Acute Myocardial Infarction, Subclinical Depression
SUBDIMA: Subclinical Depression in Acute Myocardial Infarction (SUBDIMA25)
This is an exploratory, prospective, non-profit study (SUBDIMA) designed to investigate the prevalence and potential prognostic significance of subclinical depression in patients admitted with a first acute myocardial infarction…
- Trial name
- SUBDIMA25 (NCT07492537)
- Testing
- Psychological, Cognitive, and Patient-Reported Outcome Assessments
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metastatic Ovarian Cancer
Prognostic and Predictive Value of HE4 Biomarker in Metastatic Ovarian Cancer
HE4 is a new marker that could improve the detection of ovarian cancer. The HE4 assay may have an advantage over the CA-125 assay in that it is less frequently positive in patients with non malignant disease.
- Trial name
- Meta-Four (NCT01768156)
- Testing
- Experimental arm
- Where
- 2 sites in France
- Volunteers
- 101 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Pneumonia in Children
Roles of Some Non-classic Biomarkers in Pediatric Pneumonia
The current work aims to: 1. Measure the levels of Neutrophil CD64 Receptor, Monocyte Human Leukocyte Antigen-DR (mHLA-DR), and Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) in children suffering from pneumonia. 2.
- Trial name
- NCT05701605
- Volunteers
- 120 people
- Sponsor
- Assiut University
Sepsis
Diagnostic and Prognostic Biomarkers of Sepsis
This study aims to evaluate sepsis biomarkers as soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and soluble urokinase plasminogen activator receptor (sUPAR) in diagnosis of sepsis in comparison to the…
- Trial name
- NCT04767893
- Where
- Egypt
- Volunteers
- 67 people
- Sponsor
- Sohag University
Neuroblastoma, Ewing Sarcoma
Β3-adrenoreceptor As Prognostic Marker in Neuroblastoma and Ewing Sarcoma
This study on biological samples of patients affected by neuroblastoma and Ewing sarcoma aims at validating the beta3-adrenoreceptor as prognostic biomarker.
- Trial name
- NCT06851221
- Testing
- beta3 expression
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- Meyer Children's Hospital IRCCS
Pancreas Adenocarcinoma
Circulating Extracellular Exosomal Small RNA as Potential Biomarker for Human Pancreatic Cancer
This study is for the verification of biomarkers for pancreatic cancer treatment using small RNA liquid biopsy, combined with EUS-FNA tissues.
- Trial name
- NCT04636788
- Testing
- Venous sampling
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Gastric Cancer
Circulating Exosomes As Potential Prognostic And Predictive Biomarkers In Advanced Gastric Cancer Patients ("EXO-PPP Study")
Exosomes are formed by inward budding of late endosomes, producing multivesicular bodies (MVBs), and are released into the environment by fusion of the MVBs with the plasma membrane.
- Trial name
- EXO-PPP (NCT01779583)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Pneumonia
Evaluation of a Functional Lymphocyte Test (QuantiFERON Monitor®) as a Prognostic Marker for Acute Community-acquired Pneumonia
Lower respiratory infections, or pneumonia, remain the third leading cause of death worldwide, despite progress in vaccinating at-risk populations and improved resuscitation techniques.
- Trial name
- LYMPHONIE (NCT03505281)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Amblyopia
Plasma Biomarker in Amblyopia Patients
This prospective study aims to observe the predictive effect of peripheral blood plasma biomarker on the outcome of treatment in children with different types of amblyopia.
- Trial name
- NCT05705778
- Testing
- standard amblyopia treatment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Sleep Apnea Syndrome, Heart Failure
PRevalence, Persistence and prOgnostic ValuE of Sleep Apnea Syndrome in Acute Heart Failure
The prevalence of sleep-disordered breathing is common in patients with stable chronic heart failure (up to 83%). Basically, the SAS is divided into two categories: central SAS (CSAS) and obstructive SAS (OSAS).
- Trial name
- PROVE-SAS-AHF (NCT02317848)
- Testing
- polygraphy and ECG
- Where
- 4 sites in France
- Volunteers
- 54 people
- Sponsor
- French Cardiology Society
Breast Neoplasms
Sweden Cancerome Analysis Network - Breast : Genomic Profiling of Breast Cancer
This study evaluates the genomic profiles of breast cancer in a prospective and population-based manner. In the first phase, breast tumors are analyzed by whole transcriptome RNA-sequencing.
- Trial name
- SCAN-B (NCT02306096)
- Where
- 10 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Lund University
Ovarian Cancer, High Grade Ovarian Serous Adenocarcinoma
High Definition Profiling of Ovarian Cancer Ascites
This project entails the collection of a prospective cohort of ascites (AS) samples from High Grade Serous Ovarian Cancer (HGSOC) patients.
- Conditions
- Ovarian Cancer, High Grade Ovarian Serous Adenocarcinoma, Ascites
- Trial name
- NCT06553742
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- European Institute of Oncology
Portal Hypertension
Non-invasive Evaluation Program for TIPS and Follow Up Network
Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension.
- Trial name
- NEPTUN (NCT03628807)
- Where
- Germany
- Volunteers
- 747 people
- Sponsor
- University Hospital, Bonn
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Biomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors
This study investigates the clinical course of CDK4/6 inhibitor treated patients in the real-world setting among patients with breast cancer.
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8
- Trial name
- NCT04526587
- Testing
- Cytology Specimen Collection Procedure, Diagnostic Laboratory Biomarker Analysis, Medical Chart Review
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Roswell Park Cancer Institute
Chronic Heart Failure
Prognostic and Diagnostic Value of Biomarkers and Cardiac Functional Parameters in Patients With Chronic Heart Failure
The study aims to investigate whether disease progression in patients with chronic heart failure (CHF) can be assessed by new biomarkers, and determine their diagnostic value.
- Trial name
- NCT02776384
- Testing
- Observational study
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Lung Nodule, Lung Cancer
Biobank for the Identification of Biomarkers in Lung Cancer (BIRD, Biomarkers in Respiratory Disease)
The BIRD biobank aims at collecting clinical and biological data from patients suffering from a chronic respiratory disease. The lung cancer subpopulation will be divided into two cohorts to identify biomarkers of cancer.
- Trial name
- BIRD-NK (NCT06054854)
- Testing
- Extra blood sampling, Non-invasive or leftover samples or medical waste
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Preterm Labour
Monocyte Chemotactic Protein-1 (MCP-1) Expressing Monocytes to Predict Preterm Delivery: PhenoMAP Study
The threat of preterm labour (PTL) is the first cause of hospitalization in the course of pregnancy. Its diagnostic is based on clinical examination with a positive predictive value of about 40 %.
- Trial name
- PHENOMAP (NCT01340222)
- Testing
- biological samples
- Where
- France
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Chest Pain, Coronary Artery Disease
Risk Markers in the Acute Coronary Syndromes
The main aim of this trial is to assess the long-term prognostic value of different types of Factor XIIa in an unselected, single center series of 871 chest pain patients admitted to the emergency unit, employing blood samples…
- Conditions
- Chest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
- Trial name
- RACS (NCT00521976)
- Where
- Norway
- Volunteers
- 871 people
- Sponsor
- Helse Stavanger HF
Cardiac Arrest
Prognostic Value of Plasma Mitochondrial DNA and Cytochrome C After Cardiac Arrest
The aim of the study is to determine prognostic value of plasma mitochondrial DNA and cytochrome C after cardiac arrest. The study will be conducted in three parts: 1.
- Trial name
- NCT03539497
- Testing
- Biomarker
- Where
- Slovenia
- Volunteers
- 87 people
- Sponsor
- University Medical Centre Ljubljana
Non Squamous Non Small Cell Lung Cancer, EGFR Positive Non-small Cell Lung Cancer
Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation
This study was designed to investigate the efficacy and safety of neoadjuvant Toripalimab (anti-PD1) plus chemotherapy for patients with resectable II-IIIB non-squamous NSCLC harboring EGFR mutation, and to explore the potential…
- Trial name
- NCT05962021
- Testing
- Toripalimab plus Chemotherapy
- Volunteers
- 126 people
- Sponsor
- Peking University People's Hospital