Clinical trials: Progression
Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression
A Multicenter Registry-Based Study Across the Spectrum of Degenerative Cervical Myelopathy
This is a multicenter, prospective, longitudinal, observational registry-based study of degenerative cervical myelopathy (DCM) across the full disease spectrum, linked to a disease-specific biobank.
- Conditions
- Degenerative Cervical Myelopathy, Non-myelopathic Degenerative Cervical Cord Compression, Asymptomatic Degenerative Cervical Cord Compression, Cervical Spinal Cord Compression
- Trial name
- DCM-RB (NCT07641699)
- Testing
- Registry-based observation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies
Mayo AVC Registry and Biobank
Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT03049254
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Myopia
The Incidence and Progression of Myopia: Cohort Study
A cohort study on incidence and progression of myopia in a group of medical students
- Trial name
- NCT03244670
- Testing
- Observation study only, no specific intervention
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Parkinson's Disease, Dysarthria
Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison
Parkinson's disease (PD) affects between 1% and 2% of the world's population aged 60 and older; in Europe the prevalence is around 150 PD patients per 100,000 individuals.
- Conditions
- Parkinson's Disease, Dysarthria, Speech, Cross-language
- Trial name
- FraLusoPark (NCT02753192)
- Testing
- Patients
- Where
- 3 sites in France, Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
Cystic Fibrosis (CF)
Long Term Significance (Survival) of LCI in Patients With Cystic Fibrosis
The current dream in CF research is to discover safe drugs that correct the basic defect and prevent lung disease, allowing patients without significant lung damage to live nearly normal lives with a dramatic increase in life…
- Trial name
- NCT01951833
- Testing
- EasyOne Pro and Ecomedics
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Nicotine Dependence
EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd < 5) using an 18-month longitudinal design and to relate these predictors of progression to the…
- Trial name
- NCT02129387
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University Carbondale
Myopia
The Evaluation of Safety and Myopia Progression Control Using Novel Spectacle Lens
The goal of this clinical trial is to test Novel spectacle lenses in myopic children. The main question it aims to answer are: safety and efficacy of the lenses.
- Trial name
- NCT05886348
- Testing
- Model-A Novel spectacle lens, Model-B Novel spectacle lens, Single vision spectacle lens
- Where
- 5 sites in China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- HOYA Lens Thailand LTD.
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Myopia, Myopia Progression
Spectacle Lens Visual Acuity Assessments Study
This is a two-arm parallel group, non-dispensing study. Participants will be existing active CYPRESS Extension (CPRO-1802-002) subjects. Subjects will undergo additional visual performance assessments.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- CEDAR (NCT05650190)
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- 6 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia
Pilot Study to Assess the Efficacy of Short Exposure to Defocus to Slow the Progression of Myopia in Children
The objective of this pilot study is to establish whether brief periods of high levels of acutely imposed myopic defocus can be used to slow the progression of myopia in children, as measured by changes in spherical equivalent…
- Trial name
- NCT00400140
- Testing
- Hyperopic lens
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Coronary Atheroscleroses, Coronary Angiography
Risk Factors of Intermediate Coronary Lesion Progression
Coronary intermediate lesions generally refer to lumen narrowing with diameter stenosis% (DS%) between 50% and 70% on angiography.
- Trial name
- NCT03855436
- Where
- China
- Volunteers
- 1,389 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Myopia, Myopia Progression
Children's Viewing Behavior
The aim of this study is to investigate the area of the spectacle lens in which a subject is viewing through regardless of task being performed.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- NCT07229365
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Muscle Contractile Properties, Resistance Exercise
Foot Progression Angle and Leg Press: Vastus Medialis Contractile Responses
This study examined the interaction between rotational foot positioning during leg press and individuals' habitual foot progression angle (FPA) phenotype on the acute contractile response of the vastus medialis muscle
- Conditions
- Muscle Contractile Properties, Resistance Exercise, Foot Progression Angle
- Trial name
- NCT07546851
- Testing
- Congruent Foot Position Leg Press, Incongruent Foot Position Leg Press
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Giresun University
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
HIV Infections, Papillomavirus Infections
Viral Load Determination and Biomarkers of High Risk Human Papillomavirus (HPV) - Types in HIV-positive Men
Human papillomavirus (HPV)-infection belongs to the most common sexually transmitted diseases worldwide. HIV-infected men having sex with men (MSM) are strongly associated with a higher prevalence of genital HPV-infection, a…
- Conditions
- HIV Infections, Papillomavirus Infections, Anal Intraepithelial Neoplasia
- Trial name
- NCT00365729
- Testing
- Smear and biopsy testing for HPV-types and viral load
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Deutsche Luft und Raumfahrt
Stroke, Acute, Educational Problems
Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge
This study is a single-center, randomized, open-label, controlled, endpoint-blinded study to assess the effect of off-script diagnosis \& differential diagnosis (D\&D) training in improving the residents' knowledge of acute…
- Conditions
- Stroke, Acute, Educational Problems, Clinical Course
- Trial name
- CAST-AIS (NCT06941753)
- Testing
- Off-script diagnosis & differential diagnosis (D&D) training
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Psoriasis (PsO), Periodontal Disease
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls
Background: Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population and is linked to immune dysregulation and systemic inflammation.
- Trial name
- NCT06897722
- Testing
- TNF-α analysis in GCF, IL-17A analysis in GCF, YKL-40 analysis in GCF
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhala Vatankha Sain
Tooth Erosion, Tooth Wear
Association Between Erosive Tooth Wear Progression and Dietary Risk Factors.
Study to determine if whether or not exist an association between the tissue loss (ETW progression) and the frequency of an acidic diet.
- Conditions
- Tooth Erosion, Tooth Wear, Erosion, Dental Erosion
- Trial name
- NCT04586322
- Testing
- No intervention, (observational study).
- Where
- Belgium
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Ghent
Robot-Assisted Radical Prostatectomy Training, Prostatectomy
Comparing Two Training Methods for Learning Robot-Assisted Radical Prostatectomy
This randomized non-inferiority study evaluates whether a robot-assisted radical prostatectomy (RARP) training pathway incorporating the IMRA Surgical Prostatectomy Class V Hydrogel Model is as effective as the current standard…
- Trial name
- NCT07669974
- Testing
- IMRA-Enhanced Training Pathway, Standard Training Pathway
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Orsi Academy
Colorectal Cancer
Implication of Long Non-coding RNA CCDC144NL-AS1/Micro RNA-143-3p Axis Expression Level as Novel Signature in Colorectal Cancer
Elucidate the role of lncRNA CCDC144NL-AS1, hsa-miR-143-3p, and HMGA2 protein as non-invasive epigenetic molecular biomarkers in liquid biopsy of CRC Egyptian patients, individually or as an interaction arm and in comparison, to…
- Trial name
- NCT06427278
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University