Clinical trials: Progression
Study Focus: Simulation and Proficiency Based Training
Proficiency Based Training in Surgery - Employing An Arthroscopic Bankart Repair
This study examines in a prospective, randomized and blinded study design the impact of a proficiency based training methodology on the acquisition of arthroscopic surgical skills employing both a dry shoulder simulator model…
- Trial name
- NCT01921621
- Testing
- Group B - Simulation Training, Group C - Proficiency Based Progression
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Arthroscopy Association of North America
Glaucoma
Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma
To obtain demographic and baseline ophthalmic parameters (such as Intraocular Pressure profiles, disc morphological characteristics, central corneal thickness, peripapillary retinal nerve fibre layer thickness and its serial…
- Trial name
- NCT00321386
- Where
- 2 sites in Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Myopia
Discontinuation of Orthokeratology on Eyeball Elongation in Myopic Children
The primary aim of this study is to compare eyeball elongation in existing ortho-k subjects who stop the treatment with subjects who continue ortho-k lens wear and control subjects wearing single-vision glasses.
- Trial name
- DOEE1 (NCT01236742)
- Testing
- ortho-k lenses, single-vision glasses
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Non-proliferative Diabetic Retinopathy, Diabetes Mellitus Type 2
Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy
The purpose of this study is to evaluate the efficacy of ubiquinone and combined antioxidant therapy on progression, clinical regression, oxidative stress markers and mitochondrial dysfunction in non-proliferative diabetic…
- Trial name
- NCT02062034
- Testing
- Ubiquinone, Combined antioxidant therapy
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Multiple Sclerosis
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures.
- Trial name
- NCT00001248
- Where
- United States
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Myopia
Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate
The goal of this clinical trial is to compare pharmacological and non-pharmacological treatment effects on the children with different predicted myopia progression rate measured by modified multifocal electroretinogram.
- Trial name
- NCT06282848
- Testing
- Atropine 0.05%, DIMS lens
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
COVID-19
An Early Warning Model for Assessing the Onset, Progression and Sequelae of COVID-19
Based on the characteristics of symptoms, differences in physical and chemical examinations and tests, and characteristics of traditional Chinese medicine (TCM) disease differentiation and syndrome differentiation, the evaluation…
- Trial name
- NCT05761652
- Testing
- Observe and record
- Where
- China
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Lung Cancer, Esophageal Cancer
A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizumab Combined With Pulsed Low-dose Rate External Irradiation (PLDR)
At present, the treatment methods for recurrent cancers are very limited. The immune checkpoint inhibitors (ICBs) is a promising new directions for recurrent lung cancer/ esophageal cancer / cervical cancer, but the clinical…
- Conditions
- Lung Cancer, Esophageal Cancer, Cervical Cancer
- Trial name
- NCT06232083
- Testing
- PLDR+Cardunizumab
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Alzheimers Disease, Dementia
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing…
- Conditions
- Alzheimers Disease, Dementia, Alzheimers Disease, Familial
- Trial name
- DIAN-TU-002 (NCT06647498)
- Testing
- Remternetug
- Where
- 37 sites in United States, Argentina and 13 more
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease
Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease
Observational, prospective, monocentric study to assess clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients and rate of progression compared to healthy controls (HC) and subjects at risk to…
- Trial name
- ICEBERG (NCT02305147)
- Testing
- Clinical, biological and imaging followup
- Where
- France
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Placenta Previa
Low Implanted Second Trimester Placenta and Placenta Previa
Placenta Previa is defined as a placenta implanted in the lower segment of the uterus, presenting ahead of the leading pole of the fetus (over or near the internal os).
- Trial name
- NCT03431116
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dental Caries, Dental White Spot
Effect of Light Curable Resin Modified Glass Ionomer Varnish on Non-Cavitated Proximal Carious Lesions' Progression
The standard-of-care preventive measures to stop early tooth decay from becoming worse is by fluoride application, diet counseling, and oral hygiene instructions. This standard way is not always successful.
- Trial name
- NCT03685058
- Testing
- Light curable resin modified glass ionomer varnish, standard-of-care preventive measures
- Where
- Saudi Arabia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Clinical Deterioration
Multicomponent Exercise to Prevent Hospitalization-Associated Disability
The study is a randomized controlled trial conducted in the Geriatrics Department of a tertiary hospital in Spain (Hospital Universitario de Navarra).
- Trial name
- FIS_Prevention (NCT07707310)
- Testing
- Behavioral: Exercise
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Proximal Caries
Effect of Self-Assembling Peptides on the Progression of Non-Cavitated Proximal Caries
The aim of this randomized controlled, double-blinded, split-mouth clinical trial was to evaluate the efficacy of self-assembling peptide P11-4 solution (Curodont™ Repair) with fluoride varnish on the progression of non-cavitated…
- Trial name
- NCT04776785
- Testing
- Curodont™ Repair, MI Varnish™, Profluorid® Varnish
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Alzheimer Disease
Melatonin in Alzheimer's Disease: Effect on Disease Progression and Epileptiform Activity.
This is a long-term, prospective, observational study to investigate and compare the levels and rhythm of melatonin in patients with AD dementia, mild cognitive impairment due to AD and healthy volunteers.
- Trial name
- MADE (NCT04522960)
- Testing
- MEG+hdEEG+MRI
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Erosive Tooth Wear
Impact of Dietary Advice on the Progression of Tooth Wear
The aim of this research is to investigate the impact of dietary advice on the progression of tooth wear over 6 months using a randomised clinical trial design. Participants with severe tooth wear will be recruited.
- Trial name
- DAI (NCT02493803)
- Testing
- Dietary Advice
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King's College London
Primary Open Angle Glaucoma
STudy to Assess Rapid Disease Progression by Clinical and Genetic Factors In Glaucoma patientS That Are High Risk
The purpose of this study is to perform exploratory analyses to evaluate rates of functional and structural change in glaucoma, to identify predictors of rapid progression in patients with glaucoma and to identify possible…
- Trial name
- STARFISH (NCT01442896)
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
COPD
Determinants of Onset and Progression of COPD in Young Adults
COPD (Chronic Obstructive Pulmonary Disease) is a Public Health problem due to its impact in the patient's quality of life, high prevalence, growing incidence and socioeconomic implication.
- Trial name
- EARLY COPD (NCT02352220)
- Where
- Spain
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Borja Cosio
Parkinson's Disease
Effect of 2.5 Years of Rasagiline Therapy on Progression of Cognitive Biomarkers Assessed by MRI in Parkinson's Disease.
In this investigator-initiated study, we will compare changes in brain cognitive biomarkers assessed by diffusion tensor imaging over 2.5 years among 12 patients with Idiopathic Parkinson's disease (IPD) receiving rasagiline, 20…
- Trial name
- NCT02278588
- Testing
- Rasagiline
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Respiratory Insufficiency, Clinical Deterioration
Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal…
- Trial name
- NCT06442488
- Testing
- Respiratory Monitoring System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jeffrey Joseph