Clinical trials: Prolapse, Vaginal
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Vaginal Delivery, Pelvic Organ Prolapse
EASE: The Materna Prep Pivotal Study
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery.
- Trial name
- NCT03973281
- Testing
- Materna Prep Device, Standard of Care (SOC)
- Where
- 22 sites in United States
- Volunteers
- 420 people
- Sponsor
- Materna Medical
Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
Effectiveness of Perineorrhaphy in Pelvic Organ Prolapse Surgery
This is an observational registry-based study of long-term outcome after vaginal native tissue repair for pelvic organ prolapse designed to emulate a pragmatic open-label two-arm trial for which patients, in whom perineorrhaphy…
- Trial name
- PINPOPS (NCT07006129)
- Testing
- Perineorrhaphy, No perineorrhaphy
- Where
- Sweden
- Volunteers
- 40,646 people
- Sponsor
- Lund University
Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse
Efficacy of Platelet Rich Plasma on Pelvic Floor Muscle Strength and Recurrence Rate in Pelvic Organ Prolapse Surgery
Pelvic organ prolapse (POP) is a common pelvic floor disorder associated with impaired quality of life and considerable postoperative recurrence following native tissue repair.
- Conditions
- Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse, Platelet Rich Plasma Injection
- Trial name
- NCT07746739
- Testing
- POP surgery adjunctive PRP
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Andalas University
Pelvic Organ Prolapse Vaginal Surgery, Platelet Rich Plasma Injection
The Effects of Platelet Rich Plasma Adjuvant to Type I/III Collagen Ratio, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Pelvic Organ Prolapse Repair
The goal of this clinical trial is to analyze the effect of Platelet Rich Plasma (PRP) Adjuvant To Type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair.
- Trial name
- POP PRP MMP (NCT07150442)
- Testing
- POP surgery and PRP injection
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Andalas University
Pelvic Organ Prolapse Vaginal Surgery, Stress Urinary Incontinence in Women
The AMPER Study: Evaluation of the Efficacy of Human Amniotic Membrane Grafting in Preventing Mesh Exposure in Vaginal Reconstructive Surgery Using Polypropylene Mesh.
This study evaluates the efficacy of adding a human amniotic membrane graft to polypropylene mesh surgery for pelvic prolapse and stress urinary incontinence.
- Trial name
- AMPER (NCT07414849)
- Testing
- Sacrospinous Hysteropexy with Mesh, Retropubic Mid-urethral Sling (Bottom-Up), Transobturator Mid-urethral Sling (Out-In)
- Where
- Argentina
- Volunteers
- 330 people
- Sponsor
- Hospital General de Agudos J. M. Penna
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
Urinary Continence After Vaginal Surgery for Genital Prolapse in the Spanish Population.
Surgical correction of pelvic organ prolapse (POP) may be associated with the development of postoperative stress urinary incontinence (SUI).
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Urinary Incontinence (UI)
- Trial name
- NCT07628036
- Testing
- Vaginal surgery for pelvic organ prolapse
- Where
- 4 sites in Spain
- Volunteers
- 1,042 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Stress Urinary Incontinence, Vaginal Prolapse
BELIEVE Trial: Bulking vErsus sLing for Treating Stress Urinary IncontinEnce at the Time of Vaginal prolapsE Repair (BELIEVE)
The goal of this clinical trial is to learn if retropubic midurethral sling (RP-MUS) or bulkamide injection (PAHG) at the time of pelvic organ prolapse repair is better from the patient's perspective.
- Trial name
- BELIEVE (NCT06754046)
- Testing
- RP-MUS, PAHG
- Where
- United States
- Volunteers
- 476 people
- Sponsor
- University Hospitals Cleveland Medical Center
Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery
The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial)
The goal of this clinical trial is to compare the Manchester procedure and vaginal hysterectomy in treating patients with symptomatic uterine prolapse.
- Conditions
- Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
- Trial name
- Fin-UP (NCT07566949)
- Testing
- Manchester procedure, Vaginal hysterectomy
- Where
- 6 sites in Finland
- Volunteers
- 426 people
- Sponsor
- Tampere University Hospital
Pelvic Organ Prolapse, Vaginal Prolapse
Cross-Shaped Vaginal Pessary for Pelvic Organ Prolapse
This prospective multicenter single-arm study evaluates the effectiveness and safety of a novel volumetric cross-shaped vaginal pessary in women with pelvic organ prolapse who had prior experience using a traditional vaginal…
- Trial name
- CROSS-PES (NCT07554651)
- Testing
- Volumetric Cross-Shaped Vaginal Pessary
- Where
- 5 sites in Ukraine
- Volunteers
- 51 people
- Sponsor
- Dnipro State Medical University
Pelvic Organ Prolapse, Pelvic Organ Prolapse (POP)
Accelerometer Measured Early Recovery After Prolapse Surgery
The AccelERate study will evaluate the physical recovery of patients who have undergone Pelvic Organ Prolapse (POP) surgery. This will be evaluated via a self-reported recovery questionnaire completed daily.
- Conditions
- Pelvic Organ Prolapse, Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse, Patient Education
- Trial name
- AccelERate (NCT07218016)
- Testing
- Postoperative Exercise regimen
- Where
- 7 sites in United States
- Volunteers
- 288 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Prolapse, Vaginal, Stress Urinary Incontinence
Perineal Massage for Pessary Examinations
Pessaries are effective non-surgical devices for reduction of prolapse. However, use of pessaries are limited in some women due to patient discomfort.
- Conditions
- Prolapse, Vaginal, Stress Urinary Incontinence, Pessaries, Pain
- Trial name
- NCT06416982
- Testing
- Perineal massage
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Vaginal Packing Following Laparoscopic Sacrocolpopexy, Pelvic Organ Prolapse
Vaginal Packing After Laparoscopic Sacrocolpopexy
Vaginal packing is used routinely following vaginal reconstructive surgery, however, no recommendation regarding vaginal packing after laparoscopic sacrocolpopexy exists.
- Trial name
- NCT02943525
- Testing
- vaginal packing
- Where
- Czechia
- Volunteers
- 253 people
- Sponsor
- Charles University, Czech Republic
Pelvic Organ Prolapse, Pelvic Organ Prolapse Vaginal Surgery
To Explore the Surgical Outcomes and Safety of an Innovative Laparoscopic Uterine Pectopexy Technique Using Inverted T-meshes for Simultaneous Apical and Anterior Vaginal Repair.
Patients referred for pelvic reconstructive surgery frequently present with combined anterior and apical vaginal wall prolapse. Previous studies found that anterior compartment involvement is the most common and serious defect…
- Conditions
- Pelvic Organ Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pectopexy, Sacrocolpopexy
- Trial name
- NCT07411898
- Testing
- Laparoscopic pectopexy, Laparoscopic sacrocolpopexy
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Chung Shan Medical University
Vaginal Vault Prolapse
Restorelle® Y Mesh vs. Vertessa® Lite Y Mesh for Laparoscopic and Robotic-assisted Laparoscopic Sacrocolpopexy
This is a randomized clinical trial to compare outcomes between the Restorelle® Y mesh and Vertessa® lite Y mesh for the treatment of vaginal vault prolapse.
- Trial name
- Lite-Y (NCT03681223)
- Testing
- Vertessa® Lite Y mesh, Restorelle® Y mesh, Laparoscopic sacrocolpopexy
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
Vaginal Mesh Surgery Versus Robotic-assisted Abdominal Mesh Surgery in the Treatment of Apical Prolapse - Prospective Randomized Non-inferiority Study
The goal of this study is to compare vaginal mesh surgery with abdominal robotic-assisted mesh surgery for the treatment of genital prolapse in women.
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Mesh Reinforcement, Vaginal Apex/Uterine Prolapse
- Trial name
- NCT07359755
- Testing
- Vaginal mesh surgery for apical prolapse, Robotic-assisted abdominal mesh surgery with Upsylon device (Boston Scientific - USA) for vaginal apical prolapse
- Where
- Brazil
- Volunteers
- 86 people
- Sponsor
- University of Sao Paulo General Hospital
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
A Comparison Between Vaginal Sacrospinous Ligament Fixation and Laparoscopic Uterosacral Ligament Suspension as a Uterine Preserving Surgery for Pelvic Organ Prolapse
The investigators present a literature review evaluating the current place of sacrospinous hysteropexy in the surgical management of pelvic organ prolapse.
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Hysterectomy
- Trial name
- POP-Q USS USLS (NCT06982157)
- Where
- Israel
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Prolapse, Vaginal Vault
Transvaginal Mesh vs. Laparoscopic Colposacropexy- Study
The main objective of the study is to compare subjective efficacy of trans vaginal mesh and laparoscopic colposakropexy (CSP) in women with an apical prolapse.
- Trial name
- TVM vs LCSP (NCT04478747)
- Testing
- TVM, Colposacropexy
- Where
- Finland
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Vaginal Cuff Complications
Post-hysterectomy Vaginal Cuff Prolapse Repair
This study is a randomized controlled trial comparing two minimally invasive surgeries-laparoscopic lateral suspension and laparoscopic sacrocolporopexy-for women who develop vaginal cuff prolapse after hysterectomy.
- Trial name
- NCT07174921
- Testing
- Laparoscopic Lateral Suspension, Laparoscopic Sacrocolpopexy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Genital Prolapse, Vaginal Floor Prolapse
Ambulatory Prolapse Surgery
Day surgery is performed in the same way as in full hospital admission, allowing same-day discharge without increased risk. It provides many grounds for patient satisfaction.
- Trial name
- PROLAMBU (NCT02585544)
- Testing
- day-care surgery
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon