Clinical trials: Prolonged Disorders of Consciousness
Prolonged Disorders of Consciousness, Tracheostomy
A Voice Valve-Based Decannulation Protoco for Patients With a Prolonged Disorders of Consciousness
To evaluate the feasibility of a standardized tracheostomy decannulation protocol for patients with prolonged Disorders of Consciousness (pDoC) .
- Trial name
- STEP-DoC (NCT07183670)
- Testing
- decannulation protocol
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Hongying Jiang, MD
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Prolonged Disorders of Consciousness
Speaking Valve Trial vs. Capping Trial for Tracheostomy Decannulation in Prolonged Disorders of Consciousness
To assess whether the speaking valve trial, when employed as an indicator for extubation during the removal of tracheostomy tubes in patients with chronic consciousness disorder, provides superior benefits and heightened…
- Trial name
- SPEAK-CAP (NCT07173634)
- Testing
- Speaking Valve Trial, Capping Trial
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Hongying Jiang, MD
Stellate Ganglion Block, Prolonged Disorders of Consciousness
Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness
The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative sleep status in patients with prolonged disorders of consciousness.
- Conditions
- Stellate Ganglion Block, Prolonged Disorders of Consciousness, Sleep
- Trial name
- NCT07274683
- Testing
- stellate ganglion block with 0.5% ropivacaine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Beijing Tiantan Hospital
Prolonged Disorders of Consciousness
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDoC) are pathologies in which there is a loss of consciousness for more than 28 days. The number of patients with pDoC is increasing as the level of critical care treatment and monitoring…
- Trial name
- NCT06473285
- Testing
- Drug: Esketamine (Continuous infusion)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Disorder of Consciousness, Vegetative State
The Use of LIFUP in Chronic Disorders of Consciousness
When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus
- Trial name
- NCT04921683
- Testing
- BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke
Evaluation of Consciousness by Brain-computer Interface in Severely Brain Damaged Patients
The objective of this study is to show that the measurement of auditory and vibro-tactile evoked potentials, or the recording of the EEG signal during a motor imaging task, can be used in routine clinical situations to explore…
- Conditions
- Traumatic Brain Injury With Prolonged Loss of Consciousness, Stroke, Brain Hypoxia
- Trial name
- AWAKE (NCT03998930)
- Testing
- Clinical evaluation of consciousness by the Coma Recovery Scale Revised (CRS-R)
- Where
- 4 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes