Clinical trials: Prolonged Disorders of Consciousness, active
Stellate Ganglion Block, Prolonged Disorders of Consciousness
Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness
This is a prospective, single-centre, single-arm, self-controlled, exploratory pilot study. The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative…
- Conditions
- Stellate Ganglion Block, Prolonged Disorders of Consciousness, Sleep
- Trial name
- NCT07274683
- Testing
- stellate ganglion block with 0.5% ropivacaine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Beijing Tiantan Hospital
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Prolonged Disorders of Consciousness, Tracheostomy
A Speaking-Valve-Based Decannulation Protoco for Patients With a Prolonged Disorders of Consciousness
To evaluate the feasibility of a standardized tracheostomy decannulation protocol for patients with prolonged Disorders of Consciousness (pDoC) .
- Trial name
- STEP-DoC (NCT07183670)
- Testing
- decannulation protocol
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Hongying Jiang, MD
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Consciousness Disorders
Micro-expressions in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness.
- Trial name
- NCT06088628
- Testing
- Facial expression; Electroencephalogram; MRI
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Consciousness Disorders, Brain Injury
Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDOC) are defined as DOC lasting >1 year post injury for patients with Traumatic Brain Injury (TBI) and >3 months post injury for patients with non-TBI and at present there are limited…
- Conditions
- Consciousness Disorders, Brain Injury, Altered Level of Consciousness
- Trial name
- NCT06930716
- Testing
- Transcutaneous vagus nerve stimulation (taVNS), Physical therapy using Hocoma, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Vegetative State, Minimally Conscious State
Restoring Awareness
The study will evaluate the safety and preliminary efficacy of saxagliptin in treating prolonged DoC through a randomized, placebo-controlled, double-blind, delayed start Phase IIA trial.
- Trial name
- NCT07918274
- Testing
- Saxagliptin (Mylan Pharmaceuticals Inc., NDC: 0378-4706-93)
- Volunteers
- 24 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Disorder of Consciousness, Paralysis
Awareness Detection and Communication in Disorders of Consciousness
STUDY OVERVIEW Brain injury can result in a loss of consciousness or awareness, to varying degrees. Some injuries are mild and cause relatively minor changes in consciousness.
- Conditions
- Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke
- Trial name
- NCT03827187
- Testing
- Motor imagery based EEG-BCI
- Where
- 18 sites in Ireland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Ulster
Disorder of Consciousness
Study of Brain Function Evaluation System for Acute and Prolonged Disorders of Consciousness
The research focuses on establishing a system for detecting loss of consciousness, developing clinical prognostic and awakening-related brain function testing criteria.
- Trial name
- NCT06097013
- Testing
- Routine clinical rehabilitation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Disorder of Consciousness
Evaluation of the MuSICCA for Measuring Awareness
Prolonged Disorders Of Consciousness (PDOC) include the Vegetative State (VS) and the Minimally Conscious State (MCS) that persist for longer than four weeks.
- Trial name
- NCT04050995
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 80 people
- Sponsor
- The Children's Trust, United Kingdom
Disorder of Consciousness
Study of Brain Function Evaluation and Intervention System for Acute and Prolonged Disorders of Consciousness
The research focuses on establishing a system for validating the effectiveness of key technologies for targeted combined non-invasive interventions in awakening consciousness.
- Trial name
- NCT05682248
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xuanwu Hospital, Beijing
Consciousness Disorders
Micro-movements in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness.
- Trial name
- NCT06406413
- Testing
- micro-movement; electroencephalogram; MRI
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prolonged Disorders of Consciousness
Speaking Valve Trial vs. Capping Trial for Tracheostomy Decannulation in Prolonged Disorders of Consciousness
To assess whether the speaking valve trial, when employed as an indicator for extubation during the removal of tracheostomy tubes in patients with chronic consciousness disorder, provides superior benefits and heightened…
- Trial name
- SPEAK-CAP (NCT07173634)
- Testing
- Speaking Valve Trial, Capping Trial
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Hongying Jiang, MD
Disorder of Consciousness, Hemorrhagic Stroke
Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness
Object: To determine the effect of cerebrolysin on prolonged disorders of consciousness caused by hemorrhagic stroke. Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury…
- Trial name
- NCT04427241
- Testing
- Cerebrolysin, Control
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Konkuk University Medical Center