Clinical trials: Prolonged Mechanical Ventilation
Abirritation in the ICU
A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU)
The purpose of this study is to evaluate the efficacy and safety of Tegileridine Fumarate lnjection for prolonged abirritation(48h to 72h) during mechanical ventilation in the ICU.
- Trial name
- NCT07372924
- Testing
- Tegileridine Fumarate lnjection, Remifentanil Hydrochloride for Injection
- Where
- 2 sites in China
- Volunteers
- 121 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Respiratory Failure, Cardiovascular Surgery
Early Percutaneous Tracheostomy for Cardiac Surgery (ETOC)
This is a phase III clinical trial comparing early tracheostomy (day 4) versus prolonged endotracheal intubation in ICU patients needing prolonged ventilatory support after cardiovascular surgery.
- Trial name
- ETOC (NCT00347321)
- Testing
- Dilatational Percutaneous tracheostomy
- Where
- France
- Volunteers
- 212 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Functional Test, COPD, Neuromuscular Disorders, Mechanical Ventilation, Weaning, Disability
MIND Score for Prolonged Mechanical Ventilation
It was decided to develop a comprehensive disability score specifically designed for patients receiving prolonged mechanical ventilation (PMV); the collection of information included in the score should not impose any further…
- Trial name
- MIND (NCT02255058)
- Testing
- No intervention
- Where
- 5 sites in Argentina, Colombia and 1 more
- Volunteers
- 129 people
- Sponsor
- Linde AG
Muscle Weakness
Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation
The primary aim of this proposal is to test the effectiveness of NMES in improving functional status and muscle function in patients requirng prolonged mechanical ventilation
- Trial name
- NCT01825135
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- RML Specialty Hospital
Mechanical Ventilation
TEDS in Prolonged Mechanical Ventilation
Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation has been shown to be beneficial in severe chronic heart failure and chronic obstructive pulmonary disease.
- Trial name
- TEDS (NCT04741724)
- Testing
- TEDS
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Chang Gung University
Mechanical Ventilation
Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation
This trial evaluates whether transcutaneous diaphragmatic/phrenic nerve stimulation (TEDS), abdominal functional electrical stimulation (abFES), or their combination, accelerates and improves the quality of weaning from prolonged…
- Trial name
- NCT07199036
- Testing
- TEDS (Transcutaneous Diaphragmatic/Phrenic Nerve Stimulation), abFES (Functional Electrical Stimulation of Abdominal Muscles)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Mechanical Ventilation Complication
The Effects of Early Mobilization and Endurance Training for Patients With Prolonged Mechanical Ventilator
The primary hypothesis is that prolonged mechanically ventilated adults who participate in an early mobilization and endurance exercise training protocol, have an improved pulmonary outcome and functional capacity and more…
- Trial name
- NCT05154786
- Testing
- Early Mobilization and endurance training, Usual Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Mechanical Ventilation Complication
Mechanical Ventilator Weaning in Chronically Ventilated Patients
Mechanical ventilation is a commonly used life-saving hospital procedure for patients with severe breathing difficulty. Some patients have difficulty separating from the ventilator and need to be removed gradually.
- Trial name
- NCT06976554
- Testing
- weaning
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Outcome
Outcome and Predictors of Mortality of Patients on Prolonged Mechanical Ventilation
Prolonged mechanical ventilation (PMV) and weaning failure are factors associated with prolonged hospital length of stay and increased morbidity and mortality.
- Trial name
- NCT06087939
- Testing
- Mechanical ventilation
- Volunteers
- 323 people
- Sponsor
- Wollo University
Prolonged Mechanical Ventilation, Respiratory Failure
EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Respiratory Failure, Critical Illness
- Trial name
- PMV (NCT07372794)
- Testing
- EIT-Guided Respiratory Physiotherapy, Conventional Respiratory Physiotherapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Anxiety, Prolonged Mechanical Ventilation
Effects of Music Therapy on Anxiety Symptoms in Patients With Prolonged Mechanical Ventilation: A Randomized Controlled Trial
The purpose of this study is to evaluate the effects of music therapy on anxiety symptoms in patients requiring prolonged mechanical ventilation (PMV).
- Trial name
- NCT07560384
- Testing
- Patient-Directed Music Therapy (PDMT), Environmental Control and Matched Interaction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Prolonged Mechanical Ventilation
Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation
This project will conduct a series of analysis of physiological and clinical data on tracheostomy patients who receive prolonged mechanical ventilation, hoping to find out the different manifestations of patients through the…
- Trial name
- NCT05634135
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
Tracheostomy Patients, Tracheostomy Decannulation
Tracheostomy Practice in Adult Intensive Care Units
ON TRACH is an international, multicentre, observational study with the aim of characterising the timing and practice of tracheostomy insertion, management, weaning and longer-term outcomes of these patients, in intensive care…
- Conditions
- Tracheostomy Patients, Tracheostomy Decannulation, Intensive Care (ICU)
- Trial name
- ON TRACH (NCT07769021)
- Where
- 13 sites in United States, Brazil and 6 more
- Volunteers
- 2,500 people
- Sponsor
- Royal College of Surgeons, Ireland
Weaning Failure
The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function
While the high flow oxygen therapy (HFOT) respiratory support system, delivered through nasal cannulas, has demonstrated clinical benefits on respiratory function, limited data exist on whether such effects are also present in…
- Trial name
- NCT04758910
- Testing
- High Flow Oxygen Therapy, T-piece
- Volunteers
- 30 people
- Sponsor
- Evangelismos Hospital
Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG)
Mechanical Power and Pulmonary Complications in CABG Surgery
This prospective observational study evaluates the association between intraoperative mechanical power (MP) - a composite measure of the total energy delivered to the lungs during mechanical ventilation - and postoperative…
- Conditions
- Postoperative Pulmonary Complications, Coronary Artery Bypass Graft Surgery (CABG), Prolonged Mechanical Ventilation
- Trial name
- MP-CABG (NCT07639489)
- Testing
- Intraoperative Mechanical Ventilation Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fusun Gozen
Chronic Critical Illness, Prolonged Mechanical Ventilation
Prediction of Functional Outcomes From Chronic Critical Illness
The purpose of the study is to establish clinical determinants of poor cognitive and physical functional outcome of CCI patients so that the investigators may develop and validate a multi-dimensional clinical prediction model to…
- Trial name
- NCT03159208
- Where
- 6 sites in United States
- Volunteers
- 589 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Respiratory Distress Syndrome
Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS
Prone position (placing the patient on his abdomen) has been shown to be an effective intervention to decrease mortality in adults connected to mechanical ventilation for moderate to severe Acute Respiratory Distress Syndrome…
- Trial name
- ePRONE (NCT06854627)
- Testing
- Daily prone position sessions, Prolonged prone position sessions
- Where
- 38 sites in Argentina, Chile and 4 more
- Volunteers
- 780 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Mechanical Ventilation Pressure High, Intensive Care Unit
Risk Factors for Prolonged Mechanical Ventilation in Elevated Mean Airway Pressure
This multicentric prospective clinical practice study aims at evaluating risk factors associated with a prolonged mechanical ventilation and other outcomes such as barotrauma and ICU length of stay in patients with elevated…
- Trial name
- NCT05902403
- Testing
- invasive mechanical ventilation
- Where
- 4 sites in China
- Volunteers
- 400 people
- Sponsor
- Peking Union Medical College Hospital
Mechanical Ventilation
Prognostic Estimates Among ICU Clinicians
One challenge with decision making for mechanically ventilated is that their prognosis is often uncertain. The ProVent-14 score incorporates clinical variables measured on the 14th day of mechanical ventilation to predict risk of…
- Trial name
- NCT06452797
- Testing
- ProVent-14 score
- Where
- 3 sites in United States
- Volunteers
- 238 people
- Sponsor
- Rush University Medical Center
Critically Ill
Towards RECOVER: Outcomes and Needs Assessment in Intensive Care Unit (ICU) Survivors of Prolonged Mechanical Ventilation and Their Caregivers
Advances in critical care medicine have dramatically improved the survival of critically ill patients requiring prolonged mechanical ventilation.
- Trial name
- RECOVER (NCT00896220)
- Where
- 5 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto