Clinical trials: Proof of Concept
Cough
Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients
The primary objectives of this study: To investigate the safety and tolerability of ascending repeated oral doses of BAY1902607 in healthy subjects (Part 1).
- Trial name
- NCT03535168
- Testing
- BAY1902607, Midazolam
- Where
- 8 sites in Netherlands, United Kingdom
- Volunteers
- 59 people
- Sponsor
- Bayer
HIV Infections
A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients Between Ages 4 and 22 With 7 Drugs, Some at Higher Than Usual Doses
The purpose of this study is to see if 7 drugs, some of them given at higher doses than normal, are safe and tolerated by young patients with AIDS who have failed to respond to other treatments.
- Trial name
- NCT00001108
- Testing
- Ritonavir, Nelfinavir mesylate, Saquinavir
- Where
- 19 sites in United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sensorineural Hearing Loss, Cognitive Decline
Healthy heaAring for Healthy Ageing: Data-driven Hearing Rehabilitation Intervention to Promote Healthy Hearing
The goal of the HAHA trial is to prove that the treatment of HI and prevention of HI-related cognitive decline are most likely to be effective if HI is approached as a broader neurodegenerative entity with multifaceted…
- Trial name
- HAHA (NCT06495268)
- Testing
- Individualised data-driven hearing rehabilitation, Standard care hearing rehabilitation
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Kuopio University Hospital
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Non-alcoholic Steatohepatitis, Fatty Liver
An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosis
To evaluate the safety and tolerability of Nitazoxanide (NTZ) 500mg Twice Daily (BID) after 24 weeks of treatment in patients with NASH induced Stage 2 or Stage 3 fibrosis
- Conditions
- Non-alcoholic Steatohepatitis, Fatty Liver, Fibrosis, Liver, Compensated Cirrhosis
- Trial name
- NCT03656068
- Testing
- Nitazoxanide 500mg BID
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Pinnacle Clinical Research, PLLC
Osteoarthritis of the Small Joints of the Hand
Clinical Validation Study of Personalized Orthopedic Splints With 3D Technology in Patients With Rhizarthrosis
Osteoarthritis of the hand is a chronic joint disease that usually affects one or more of the finger joints and it is a major cause of disability.
- Trial name
- NCT04678622
- Testing
- Bioferula3D
- Where
- 2 sites in Spain
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Optimus3D S.L.
Nail Psoriasis
Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails
The trial is conducted to investigate the clinical efficacy of a combination product containing calcipotriol and betamethasone formulated as an aerosol foam (Enstilar ©) for the treatment of nail psoriasis in conjunction with…
- Trial name
- LAsED (NCT04580537)
- Testing
- Enstilar, Ablative fractional laser
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Bispebjerg Hospital
Musical Performance, Neuromodulation
tDCS and Musical Performance in Young Orchestra Musicians
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) can improve the technical, expressive, and stage aspects of musical performance in young orchestra musicians aged 18 to 30 years.
- Conditions
- Musical Performance, Neuromodulation, Performance Anxiety
- Trial name
- NCT06958081
- Testing
- Active transcranial direct current stimulation (tDCS)
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta
Breast Cancer
Monoclonal Antibodies Elimination in Breast Cancer Patient
This Study evaluates covariables being able to potentially influence the elimination of the monoclonal antibodies (trastuzumab, bevacizumab and denosumab).
- Trial name
- PK-MAB (NCT02855775)
- Testing
- additional blood sample
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Type 2 Diabetes Mellitus
Randomized, Double-Blind, Placebo-Controlled, With PHX1149 in Patients With Type 2 Diabetes Mellitus
This will be a 4-week, multicenter, randomized, double-blind, parallel group, placebo-controlled, safety, tolerability, and efficacy study.
- Trial name
- NCT00530881
- Testing
- PHX1149
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Phenomix
Sleep Apnea, Sleep Apnea, Obstructive
Evaluation of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea
This proof-of-concept study is being performed to evaluate whether the hypoglossal nerve can be stimulated using a small series of electrodes placed surgically via a percutaneous approach.
- Conditions
- Sleep Apnea, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Sleep Disorder
- Trial name
- NCT06283030
- Testing
- Hypoglossal nerve stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Invicta Medical Inc.
Malaria
Studies of a Candidate Aminoquinoline Antimalarial (AQ-13)
This is an initial efficacy study of a candidate antimalarial in human subjects with uncomplicated malaria caused by the most common and most important parasite in Africa (Plasmodium falciparum).
- Trial name
- NCT01614964
- Testing
- AQ-13 Treatment, Coartem Treatment
- Where
- Mali
- Volunteers
- 66 people
- Sponsor
- Tulane University
Relapsing-remitting Multiple Sclerosis
A Proof-of-Concept Study to Correlate Retinal Nerve Fiber Layer Changes in Patients With Multiple Sclerosis Treated With Natalizumab or Interferon Beta 1-a
Phase IV, proof-of-concept, randomized, open-label, multi-center, two-arm, 9-month study to evaluate the neuroprotective effects of Natalizumab (TYSABRI®) or Interferon beta-1a (AVONEX®) treatments initiated at the time of…
- Trial name
- PRTOECT (NCT00771043)
- Testing
- TYSABRI and AVONEX
- Sponsor
- Biogen
Androgenetic Alopecia
Activated PRP for Treatment of Androgenetic Alopecia
A clinical trial to assess the effects and safety of PRP activated with pulsed electrical fields (PEFA-PRP) compared with unactivated PRP when used to treat AGA.
- Trial name
- NCT05348343
- Testing
- Autologous platelet-rich plasma
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Santiste Medical Inc.
Post COVID-19 Condition, Long COVID Syndrome
Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)
The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of…
- Conditions
- Post COVID-19 Condition, Long COVID Syndrome, Persistent COVID-19, Persistent COVID Condition
- Trial name
- THALASSA (NCT06766825)
- Testing
- Plitidepsin 1.5 mg/day
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Hypertension, Pulmonary
A Proof of Concept Study of Electrical Discharge Produced Nitric Oxide for Inhalation
Study Design: This is a two-part physiological for a device feasibility. Both studies are proof of concept descriptive pilot studies.
- Trial name
- NCT02305550
- Testing
- electrical pulsed plasma discharge synthesis of nitric oxide
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Addiction, Substance Abuse
Breathwork-assisted Treatment for Cannabis Use Disorder
The purpose of this proof-of-concept study is to evaluate the safety, feasibility and acceptability of a breathwork workshop intervention in individuals with cannabis use disorder.
- Conditions
- Addiction, Substance Abuse, Cannabis Use Disorder, Cannabis Use
- Trial name
- NCT05219825
- Testing
- Breathwork workshop
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Elias Dakwar
Widespread Chronic Pain
Chronic Widespread Pain and White Blood Cell Activation
Our goal is to conduct a proof-of-concept trial to test the efficacy of KF treatment in adolescents with severe CWP not responding to the standard of care (SOC) treatment program in a multidisciplinary tertiary care chronic pain…
- Trial name
- NCT02984397
- Testing
- Ketotifen Fumarate, Standard of Care
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Depressive Disorder, Bipolar Disorder
Nonconvulsive Electrotherapy: a Proof-of-concept Trial
This study involves pilot testing of a modified version of a proven treatment for mental illness. The treatment, electroconvulsive therapy (ECT) is used to treat more than 100,000 Americans yearly.
- Conditions
- Depressive Disorder, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT01065597
- Testing
- Nonconvulsive electrotherapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Maryland, College Park
Type 1 Diabetes Mellitus
TAK-329 Glucose Clamp Study
The purpose of this study is to compare the safety, tolerability, pharmacokinetic and pharmacodynamic properties of single doses of TAK-329 with a single dose of a subcutaneously-injected rapid-acting insulin analog in…
- Trial name
- NCT01311076
- Testing
- TAK-329, Insulin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Takeda
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