Clinical trials: Prophylactic
Chronic Pain
Prevalence of Pain Disorders in Employees of French Furniture Shop.
In France, the Direction of Research, Studies, Evaluation and Statistics, in their 2015 report on "Chronic pain: the state of health of the population in France - Indicators associated with the Public health ", shows that 34.6%…
- Trial name
- PREVADouleur (NCT03277885)
- Testing
- chronic pain
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Lyme Disease
A School-Based Intervention to Reduce Lyme Disease
Our overall purpose of this study is evaluate whether a short in-class Lyme Disease education program based on social learning theory and the Health Belief Model can impact a child's knowledge, attitude, and preventive behavior.
- Trial name
- NCT00594997
- Testing
- Education, Control (pre and post surveys)
- Volunteers
- 3,570 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Infection Control, Preventive Measures
Effectiveness of a Online Training Program With a Clinical Procedure Standardized in Units of Nursing (CPSUN)
This study evaluates if the implementation of an online platform with procedures and protocols, improve the knowledge of professionals and can have a health impact related to decreased contamination of blood cultures.
- Trial name
- CPSUN (NCT02965989)
- Testing
- Online training of a nursing technique
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ignacio Zaragoza García
Chronic Disease, Arthritis
Deep Dive Randomized Control Trial
Compare two care management support program models on medical costs and utilization.
- Conditions
- Chronic Disease, Arthritis, Uterine Diseases, Spinal Diseases
- Trial name
- NCT00793260
- Testing
- Enhanced Support, Usual-Support
- Where
- United States
- Volunteers
- 174,120 people, healthy volunteers welcome
- Sponsor
- Health Dialog
AIDS
Safety and Immunogenicity Study of AIDS Vaccine (Combined Use of DNA Vaccine and Recombinant Vaccinia Virus Tiantan)
This trial studies the safety and immunogenicity of a HIV clade B'/C DNA vaccine followed by recombinant vaccinia virus rTV boost in HIV-uninfected healthy volunteers at low or high risk of HIV infection.
- Trial name
- NCT01705223
- Testing
- DNA vaccine, DNA vaccine prime with the addition of electroporation, rTV boost
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Center for AIDS/STD Control and Prevention, China CDC
Malaria, Sickle Cell Crisis
Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease
Malaria prophylaxis is recommended for sickle cell disease patients. In Nigeria, daily proguanil or weekly pyrimethamine are the most commonly prescribed regimens, but the current policy is not effective due to poor compliance…
- Trial name
- NCT01319448
- Testing
- Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine
- Where
- Nigeria
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria in Pregnancy, Sexually Transmitted Infections
Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea
The purpose of this study is to determine whether repeated courses of sulphadoxine-pyrimethamine (SP) in combination with azithromycin given at Antenatal Clinic, leads to lower rates of low birth weight deliveries (<2.5 kg) among…
- Conditions
- Malaria in Pregnancy, Sexually Transmitted Infections, Anaemia
- Trial name
- IPTp in PNG (NCT01136850)
- Testing
- chloroquine, sulphadoxine pyrimethamine, LLIN, azithromycin, sulphadoxine pyrimethamine, LLIN
- Where
- Papua New Guinea
- Volunteers
- 2,793 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
HIV Infections
Study to Compare the Immunogenicity and Safety of Two HIV Preventive Vaccinations in Healthy Volunteers
The purpose of the trial is to evaluate the effect upon immune system of two regimens of preventive HIV vaccination in healthy adult volunteers.
- Trial name
- EV03/ANRSVAC20 (NCT00490074)
- Testing
- DNA-C, NYVAC-C
- Where
- 2 sites in France, Switzerland
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults
The purpose of this study is to determine the safety of and immune response to two experimental vaccines, designed for use in combination, for the prevention of HIV infection in healthy adults.
- Trial name
- NCT00428337
- Testing
- EP-1233, MVA-mBN32
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Drug-induced Nausea and Vomiting
Scheduled Prophylactic Antiemetics for Reduction of Emesis With Doxycycline (SPARED) Trial
Background/Purpose of the Study Doxycycline is an antibiotic used for infection prevention before surgical pregnancy termination, and a side effect of it is nausea/vomiting.
- Trial name
- SPARED (NCT02456662)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Malaria
MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention
As efforts to control malaria are stalling, and the disease is particularly severe in children under the age of two, it is imperative for countries in sub-Saharan Africa, with areas of moderate-to-high transmissions, to implement…
- Trial name
- MULTIPLY (NCT05085340)
- Testing
- Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP)
- Where
- 3 sites in Mozambique, Sierra Leone and 1 more
- Volunteers
- 94,252 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Pregnancy; HIV; Malaria
Improving PRegnancy Outcomes With PReVEntive Therapy in Africa-2 (IMPROVE-2)
2.3.3 Short technical protocol summary Background: Pregnant women represent a vulnerable population for malaria. HIV-infected women are particularly at risk.
- Trial name
- IMPROVE-2 (NCT04158713)
- Testing
- Intermittent Preventive Therapy with Dihydroartemisinin-Piperaquine
- Where
- Kenya
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
COVID-19
A Phase III Study of COVID-19 Vaccine EuCorVac-19 in Healthy Adults
This is a phase III, randomized, observer-blind, active-controlled, parallel group, multi-center study to compare the immunogenicity and safety of a preventive COVID-19 vaccine EuCorVac-19 to ChAdOx1 in healthy adults aged 18…
- Trial name
- NCT05572879
- Testing
- EuCorVac-19, ChAdOx1 nCoV-19
- Where
- Philippines
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- EuBiologics Co.,Ltd
Heart Failure, Caregivers
Heart Failure Resilience Intervention for Caregivers
Heart failure (HF) patients with supportive caregivers have better physical health, emotional health, and quality of life. But caregivers have an increased risk of caregivers' own worsening health and often feel a sense of burden…
- Trial name
- HEROIC (NCT03963583)
- Testing
- HEROIC
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infections
A Phase I Trial To Evaluate the Safety and Immunogenicity of the UBI HIV-1MN PND Peptide Immunogen, Given by IM Injection, in Combination With the UBI Microparticulate Monovalent HIV-1 MN Branched Peptide Given Orally, in HIV-1 Uninfected Volunteers.
To evaluate safety and immunogenicity of 2 different HIV-1 peptide candidate vaccines, the UBI HIV-1 MN PND peptide immunogen and the UBI microparticulate monovalent HIV-1 MN branched peptide when administered sequentially by 2…
- Trial name
- NCT00000846
- Testing
- HIV-1 Peptide Vaccine, Microparticulate Monovalent, HIV-1 Peptide Immunogen, Multivalent
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid-19
A Preventive Treatment for Migrant Workers at High-risk of COVID-19
In December 2019, a novel coronavirus, now called COVID-19, emerged as a global health threat from Wuhan, China. Within weeks, the contagious virus spread within and between communities, causing a lower respiratory tract…
- Trial name
- NCT04446104
- Testing
- Hydroxychloroquine Sulfate Tablets, Ivermectin 3mg Tab, Zinc
- Where
- Singapore
- Volunteers
- 4,257 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore