Clinical trials: Propionibacterium Acnes
Acne Vulgaris
Facial Skin Microbiome in Patients With Moderate-to-Severe Acne Vulgaris Treated With Isotretinoin
Acne vulgaris is associated with changes in the facial skin microbiome, but longitudinal microbiome changes during isotretinoin therapy remain incompletely understood.
- Trial name
- FACEMICRO (NCT07834138)
- Testing
- ISOtretinoin 10 MG
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Joint Arthroplasty, Shoulder
Reduction of Bacterial Seeding in Total Shoulder Arthroplasty
The purpose of this study is to compare the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus Prontosan wound gel applied to the skin…
- Conditions
- Joint Arthroplasty, Shoulder, Cutibacterium Acnes, Prosthetic Joint Infection
- Trial name
- NCT07406893
- Testing
- Prontosan Wound Gel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Disc Degeneration
Low-grade Infections of the Intervertebral Discs
The purpose of this prospective, observational study was to evaluate frequency and characteristics of low-grade infections of the intervertebral discs in an unselected real-life patient population undergoing surgery for…
- Trial name
- NCT04712487
- Testing
- Microbiological culture, viral PCR, histopathological analysis
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Kepler University Hospital
Cutibacterium Acnes Contamination
Wound Irrigation Comparative Effectiveness Study
The primary objective of this study is to compare the presence of C acnes in bacteriologic cultures taken from participant samples of subcutaneous and deep tissue prior to deep surgical irrigation using either Normal Saline…
- Trial name
- NCT06379919
- Testing
- Irrisept Irrigation, Saline Irrigation Solution Delivery
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Education and Research Institute (dba Hoag Orthopedics)
Acne Vulgaris
Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris
To evaluate and compare the anti-biofilm activity of Salicylic acid, Isotretinoin, and N-acetylcysteine against C. acne . To assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the…
- Trial name
- NCT06179056
- Testing
- assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Acne Vulgaris, Acne
Safety and Efficacy of MBI 226 1.25% and 2.5% Topical Acne Solutions in the Treatment of Acne
This is a Phase II, randomized, vehicle-controlled, double-blind, multi center study to evaluate the efficacy and safety of topically applied MBI 226 1.25% and 2.5% Acne Solutions as anti-acne preparations in human subjects with…
- Conditions
- Acne Vulgaris, Acne, Propionibacterium Acnes
- Trial name
- NCT00211497
- Testing
- MBI 226 Acne Solutions
- Volunteers
- 255 people
- Sponsor
- BioWest Therapeutics Inc
Infections Joint Prosthetic
Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections
Cutibacterium acnes is involved in nearly 40% of shoulder prosthetic joint infections (PJI). After shoulder prothesis, C. acnes mainly affects hip prosthesis.
- Trial name
- RIFACute (NCT05902221)
- Testing
- amoxicillin or moxifloxacin, amoxicillin or moxifloxacin + rifampicin
- Where
- 13 sites in France
- Volunteers
- 235 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Surgery, Surgical Site Infection
SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty
Comparing the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus antimicrobial wound gel versus betadine applied to the skin layer after…
- Conditions
- Surgery, Surgical Site Infection, Cutibacterium Acnes, Prosthetic-joint Infection
- Trial name
- NCT05919888
- Testing
- Povidone-Iodine, SURGX Wound Gel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Prosthesis and Bone Infections, Cutibacterium Acnes
Cutibacterium Acnes in Bone and Joint Infections
Prosthetic Joint Infections (PJIs) are increasing with the use of orthopedic devices on an ageing population. Cutibacterium acnes is a commensal organism that plays an important role in the ecosystem healthy human skin, yet this…
- Trial name
- CaBJI (NCT03950063)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Acne
Evaluation of the Role of Propionibacterium Acnes in the Inflammatory Lesions Associated With Acne Vulgaris
The purpose of this study is to determine the response of acne patients and healthy control patients to the P. acnes bacteria. Half a tube of blood will be drawn from all participants to determine whether or not they have…
- Trial name
- NCT01929057
- Testing
- Skin biopsy, Blood draw
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Propionibacterium Acnes
BPO vs Hibiclens Soap for Surgical Preparation
This is a randomized trial of benzoyl peroxide soap versus Hibiclens soap for surgical preparation. The objective is to determine whether benzoyl peroxide soap, commonly available in drug stores for over-the-counter acne…
- Trial name
- NCT04021524
- Testing
- Benzoyl Peroxide 10% Bar, Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Acne
Blue Light Therapy of C. Acnes
This proposal aims to investigate a novel light-based treatment to reduce morbidity in shoulder surgical patients. This has potential to improve outcomes and reduce health care utilization associated with infectious complications…
- Trial name
- NCT04300010
- Testing
- 5% Topical Benzoyl Peroxide Gel, Blue Light Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Rotator Cuff Tears of the Shoulder
Acne Face Wash for Reducing the Contamination Rate in Arthroscopic Rotator Cuff Repair Surgery
Previous studies have shown that even when following standard sterilization protocols, the positive culture rate of Cutibacterium acnes can still be as high as 30%.
- Trial name
- NCT07239349
- Testing
- Acne face wash
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Propionibacterium
Does Preoperative Administration of Oral Doxycycline Decrease the Colonization Rate of Propionibacterium Acnes in the Dermis of the Shoulder?
The purpose of this study is to evaluate the ability of oral doxycycline to decrease the colonization of Propionibacterium acnes in the dermis of the shoulder.
- Trial name
- NCT02688738
- Testing
- Doxycycline
- Sponsor
- Rothman Institute Orthopaedics
Cutibacterium Acnes
Do Wound Protectors Reduce Contamination in Total Shoulder Arthroplasty?
Prosthetic joint infection is a devastating complication of shoulder arthroplasty. A relatively novel method of preventing PJI has been with the use of a wound protection device.
- Trial name
- NCT06513182
- Testing
- No Alexis orthopaedic protector, Alexis orthopaedic protector
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Infection, Intervertebral Disc Herniation
Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID)
Subclinical infection of the intervertebral disc after lumbar disc herniation surgery has been correlated to chronic low back pain and vertebral endplate changes. The most commonly reported agent is Propionibacterium acnes.
- Conditions
- Infection, Intervertebral Disc Herniation, Propionibacterium Infection, Spinal Diseases
- Trial name
- SPInE-ID (NCT03158766)
- Testing
- Microdiscectomy
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Hospital Israelita Albert Einstein
Surgical Site Infection
Topical Treatment and Prevalence of P. Acnes
This study is about preventing surgical site infections of the shoulder. We hope to learn if clindamycin alone, benzoyl peroxide alone, or clindamycin and benzoyl peroxide together can affect growth of Propionibacterium acnes in…
- Trial name
- NCT03257202
- Testing
- Clindamycin 1% Gel, Benzoyl peroxide 5% gel, BenzaClin 5%-1% Topical Gel
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Rotator Cuff Tear Arthropathy, Spine Degeneration
Cutibacterium Acnes in Deep Tissues in Primary Spine and Shoulder Surgery
Obtain deep tissue samples from patients undergoing primary prosthetic surgery of the shoulder and patients undergoing primary instrumented surgery of the spine.
- Trial name
- NCT05355844
- Testing
- Benzoyl peroxide
- Volunteers
- 200 people
- Sponsor
- Hospital del Mar
Dihydrotestosterone, Periprosthetic Joint Infection (PJI)
Finasteride and Cutibacterium
High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection.
- Conditions
- Dihydrotestosterone, Periprosthetic Joint Infection (PJI), Cutibacterium Acnes
- Trial name
- NCT07731802
- Testing
- Finasteride 1 mg
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cutibacterium Acnes Infection
Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients
Infections on joint replacements remain one of the most serious complications of orthopaedic surgery. Despite improvements in skin preparation and antibiotic prophylaxis procedures, the risk of infection of joint prosthesis is…
- Trial name
- OPRICA (NCT04028401)
- Testing
- 5% benzoyl peroxide
- Where
- 6 sites in France
- Volunteers
- 110 people
- Sponsor
- Nantes University Hospital