Clinical trials: Propofol
Precedex Effect to Propofol Requirement
The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway
Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough…
- Trial name
- NCT02284672
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Kidney Transplant
Effects Of Propofol And Sevoflurane On Plasma Mirna Levels İn Living Kidney Donors
Surgical interventions and associated tissue trauma induce a complex systemic inflammatory stress response characterized by the activation of neuroendocrine, metabolic, and immunological systems.
- Trial name
- NCT07760402
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Propofol, Glioma
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity.
- Conditions
- Propofol, Glioma, Auditory Event-related Potential (AERP), Electroencephalogram (EEG)
- Trial name
- NCT05352685
- Testing
- Propofol Injection
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Cognitive Functioning, Propofol
The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function
This study want to observe the effects of remimazolam and propofol for general anesthesia on postoperative rhythm and cognitive function.
- Conditions
- Cognitive Functioning, Propofol, Remimazolam, Circadian Rhythm
- Trial name
- NCT06775366
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Ophthalmic
Bispectral Index Monitoring In Pediatric Cataract Surgery: A Comparative Study Using Propofol-Midazolam Versus Sevoflurane Anesthesia
Ocular alignment will be studied in children having cataract surgery that will be divided into two groups, one group will be anesthetized using sevoflurane anesthesia (group A), and the other will be anesthetized by midazolam…
- Trial name
- NCT05262205
- Testing
- measuring depth of anesthesia and its relation to the globe
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Cognitive Impairment, Mild
Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With MCI
According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups.
- Trial name
- MCI (NCT03165396)
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Third Central Clinical College of Tianjin Medical University
Pain, Acute, Analgesia
Preanesthetic Analgesia/Nociception Index (ANI) and Propofol Injection Pain
Recently, Analgesia Nociception Index (ANI) has been evaluated for objectively measuring peri-operative pain and to guide intra-operative opioid administration during various surgeries.
- Conditions
- Pain, Acute, Analgesia, Nociceptive Pain
- Trial name
- NCT05049577
- Testing
- Analgesia/Nociception Index (ANI)
- Where
- South Korea
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Patients Undergoing Rigid Bronchoscopy
A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor
Standard ASA fasting guidelines will be followed. IV 20 gauge cannula will be inserted and dedicated to the infusion drugs. Standard ASA monitors will be attached, and baseline heart rate (HR), mean arterial blood pressure (MAP)…
- Trial name
- NCT07409935
- Testing
- Propofol saline, Propofol Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neuromuscular Monitoring
Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane
Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.
- Trial name
- NCT02711917
- Testing
- MAC 0.5, MAC 0.75, MAC 1.0
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Vitreous Detachment
Comparison of Propofol Target Controlled Infusion (TCI) and Sevoflurane
This study was an experimental, single-blinded, randomized controlled trial that aimed to compare recovery time between TCI propofol and sevoflurane.
- Trial name
- NCT04865991
- Testing
- TCI Propofol, Sevoflurane
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Electroencephalography, Aging
Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.
The aim of this study is to describe the BIS values and electroencephalographic patterns during total intravenous anesthesia with propofol-remifentanyl, in patients from 18 to 85 years.
- Conditions
- Electroencephalography, Aging, Propofol, Depth of Anesthesia
- Trial name
- NCT04774120
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy Volunteer
To Study the Pharmacokinetic and Cardiovascular Effects of Propofol With Respect to Pharmacogenetics in Pakistani Population
This study aimed to determine the effects of genetic variabilities among the Pakistani population on propofol serum concentration and its adverse effects mainly cardiovascular adverse effects.
- Trial name
- NCT05383534
- Testing
- Propofol Injection
- Where
- Pakistan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Healthy Volunteers, General Anaesthesia
Neuroplasticity Induced by General Anaesthesia
The aim of this study is to use magnetic resonance imaging to explore and compare possible de novo neuroplastic changes induced by the isolated effects of the hypnotic agents sevoflurane and propofol, respectively.
- Conditions
- Healthy Volunteers, General Anaesthesia, Neuroplasticity
- Trial name
- DANA1 (NCT04125121)
- Testing
- Sevoflurane-propofol
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Signe Sloth Madsen
Preoperative Anxiety
Lavender Oil on Preoperative Anxiety and Sedation Requirement in General Anaesthesia
Assessment of how Lavender oil reduces preoperative anxiety and subsequently influences requirement of induction agents for general anesthesia.
- Trial name
- NCT03460145
- Testing
- Lavender Oil on Nasal Strip (Lx), Strip without Lavender Oil (Px), Propofol 1 % Injectable Suspension
- Where
- Malaysia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging.
Propofol Induction's Effect on Cardiac Function
Background: Propofol effects dose-dependent myocardial depression, but there is little clinical data available regarding the direct impact of propofol induction on myocardial function.
- Conditions
- This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia,, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging., This is the First Study, to Our Knowledge, Which Has Evaluated the Possible Impact of Propofol Induction on LV Function.
- Trial name
- NCT02408341
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Colonoscopy
Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
An ideal sedative for colonoscopy should have properties that include: rapid onset and offset of action, provide cardiopulmonary stability, have minimal adverse effects, and allow for smooth recovery, and early discharge.
- Trial name
- NCT03139279
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Anesthesia
Intermittent Boluses Versus Infusion of Propofol During Gastroscopy
It is unclear whether continuous infusion or intermittent bolus injection of propofol is better for achieving adequate sedation during a standard upper endoscopy.
- Trial name
- NCT06378879
- Testing
- Propofol 100 MG in 10 ML Injection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al-Balqa Applied University
Gender, Anesthesia
Dosage of Propofol Based on Lean Body Weight
Patients who will be anesthesia induced with propofol will be body analyzed with Tanita before the operation. Height, weight, age, gender and other general information of the patients will be recorded.
- Trial name
- NCT06018623
- Testing
- It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Inonu University