Clinical trials: Propofol
Anesthesia, Urologic Diseases
Sedation and Analgesia Using PFK Versus General Anesthesia in Urological Procedures
Anesthesia in urological surgeries might constitute a great challenge to anesthesiologists. Especially that a great proportion of these patients are elderly with a lot of comorbidities.
- Trial name
- NCT04285528
- Testing
- General anesthetia Fentanyl and Propofol, PFK
- Where
- Jordan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Total Intravenous Anaesthesia, Eleveld Model, Obes
Prospective Validation Of The Eleveld TCI Model For Propofol In The Malaysian Obese Population
This is a prospective single blinded randomized trial to validate the 2014 published and widely used Eleveld TCI model which is a universal model suitable for use in all age groups and is suitable for all patients even in the…
- Trial name
- NCT05885100
- Testing
- Eleveld Model
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
General Anesthesia
Exploratory Study of Propofol and Fentanyl Pharmacodynamics
Exploration of the hypothesis that general anesthesia is not a singular threshold but is a continuum of central nervous system depression dependent on interpretation of nociceptive stimuli.
- Trial name
- NCT01550770
- Testing
- propofol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ethicon Endo-Surgery
Perinatal
Study on the Fetal Safety of New Coronavirus Vaccination for Couples During the Peri-pregnancy Period
All the pregnant women and newborns of both or one of the couples who gave birth in Ditan hospital were collected as the observation group, and the pregnant women and newborns of both husband and wife who gave birth in our…
- Trial name
- NCT05125770
- Testing
- New crown vaccine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Ditan Hospital
Anesthesia, Surgery
Effect of Different Administrations of Propofol on Emergence Agitation in Preschool Children Undergoing Ambulatory Surgery
This study evaluates the influence of different dose and methods of propofol on emergence agitation(EA) through a randomized controlled trial when preschool children undergoing ambulatory surgery of inguinal hernia.
- Trial name
- NCT05420402
- Testing
- Propofol bolus, Propofol continuous infusion
- Where
- China
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Jiaxiang Chen
Uterus Myoma, Uterine Cancer
Effect of Anesthetic Agents on Optic Nerve Sheath Diameter
The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.
- Trial name
- NCT03701529
- Testing
- Sevoflurane, Propofol
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Deep Sedation
Prospective Validation of the Eleveld Model of Propofol for Procedural Sedation in Adults.
The goal of this prospective observational study is to identify effect site concentrations (CET) of propofol using the Eleveld model for different levels of procedural sedation.
- Trial name
- NCT06325033
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Dream, Day, Ketamine Adverse Reaction
The Impact of Preoperative Suggestion on Dreaming
Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.
- Conditions
- Dream, Day, Ketamine Adverse Reaction, Propofol Adverse Reaction
- Trial name
- NCT06609538
- Testing
- Control Group, Suggestion Group
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Hypothyroidism, Anesthesia, General
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Introduction: GABAergic synaptic transmigration in the anterior cingulate (ACC) cortex of hypothyroid rats has been demonstrated by electrophysiologic recordings.
- Conditions
- Hypothyroidism, Anesthesia, General, Propofol Dosage, Magnetic Resonance Imaging (MRI)
- Trial name
- BrainGABA (NCT06649318)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Children
Effects of Propofol and Ketofol on Core Body Temperature in MRI
Investigators researched the effect of two different types of drugs on core body temperature during magnetic resonance imaging. The hypothesis is in ketamine group, thermo disregulation is not as distinct as in propofol group…
- Trial name
- NCT02931786
- Testing
- propofol, Ketamine propofol mixture
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Smell Functions, Odor Memory
Effects of Different Anesthesia on Odor Memory
This study aimed to research the effect of different general anesthesia administration on postoperative smell functions and memory.
- Trial name
- NCT05499845
- Testing
- butanol threshold test and smell identification tests
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
The Effect of Chronic ssrı/snrı Antidepressant Treatment on Propofol Consumption in Elective Spine Surgery
The goal of this observational study is to learn whether long-term use of selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants is related to the amount of propofol…
- Trial name
- NCT07822295
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Unconsciousness
Performance of Two Different ke0s in the Same Pharmacokinetic Propofol Model
The aim of this study was to assess the clinical performance of two different ke0s (fast and slow) in terms of propofol effect-site concentration (Ce) during the loss and recovery of consciousness, using Marsh's pharmacokinetic…
- Trial name
- NCT01011192
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centro Medico Campinas
Obesity, Morbid
Pharmacokinetics of Propofol in Morbidly Obese Patients
The objectives of this study are To determine PK of propofol in bariatric patients To identify the physiological variables that induce propofol PK changes in bariatric patients, when compared to a normal-weight population.
- Trial name
- NCT01536002
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Anesthesia
Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application
Cystoscopy is a simple, effective and reliable method in current urological practice. Anesthesia may be required in cystoscopy for therapeutic purpose, however it may not be necessary for diagnostic cystoscopy.
- Trial name
- NCT03424356
- Testing
- Rocuronium Bromide, Saline Solution, Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Patient-controlled Sedation
Patient-controlled Sedation Versus Target-controlled Infusion in Orthopaedic Surgery Under Central Neuraxial Block
Orthopaedic surgeries involving the legs can be done under nerve block, where patients will be numb of pain at the operated site but awake during surgery.
- Trial name
- NCT03647735
- Testing
- patient-controlled sedation
- Where
- Malaysia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Cholecystolithiasis
Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI)
Laparoscopic Cholecystectomy applied to Artificial pneumoperitoneum and the extent of Surgical stimulation cause the wave of hemodynamics increase vigorously, which make it difficult to judge the depth of anesthesia according to…
- Trial name
- DLTCI (NCT02116985)
- Testing
- Dual-loop TCI, manual
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Complications
Thiopental Versus Propofol During Magnetic Resonance Imagining in Children: Something Old, Something New
Magnetic resonance imagining (MRI) in children requires sedation to achieve the degree of cooperation or immobilization, necessary to complete these procedures successfully.
- Trial name
- NCT01318044
- Testing
- Propofol and Thiopental
- Where
- Albania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Pain
Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation
This protocol describes a double-blind, placebo-controlled trial intended to demonstrate the effectiveness of lidocaine at reducing pain associated wiht propofol infusion for short-term deep sedation in children.
- Trial name
- NCT00786916
- Testing
- normal saline, lidocaine
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
Colon Cancer, IBS
Patient Satisfaction With Propofol for Out Patient Colonoscopy
The primary purpose of this study is to determine if patient satisfaction with propofol is better than with non-propofol anesthesia for outpatient colonoscopies.
- Conditions
- Colon Cancer, IBS, Polyps
- Trial name
- NCT02937506
- Testing
- Propofol, Fentanyl Plus Midazolam
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mount Carmel Health System