Clinical trials: Propofol
Cholecystolithiasis
Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy
Laparoscopic Cholecystectomy applied to Artificial pneumoperitoneum and the extent of Surgical stimulation cause the wave of hemodynamics increase vigorously, which make it difficult to judge the depth of anesthesia according to…
- Trial name
- CLTCI (NCT02114437)
- Testing
- Closed-loop TCI, Opened-loop TCI
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Anesthesia
Intermittent Boluses Versus Infusion of Propofol During Gastroscopy
It is unclear whether continuous infusion or intermittent bolus injection of propofol is better for achieving adequate sedation during a standard upper endoscopy.
- Trial name
- NCT06378879
- Testing
- Propofol 100 MG in 10 ML Injection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al-Balqa Applied University
Anesthesia
Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy
the frequency of tussis, nausea and vomiting, and/or body movements observed at the insertion of the endoscope into the pharyngeal cavity or within 5 min of endoscope insertion.
- Trial name
- NCT05497492
- Testing
- propofol, propofol and sufentanil, propofol and esketamine
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
General Anesthesia
Monitoring Exhaled Propofol to Individualize General Anesthesia
This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia.
- Trial name
- EPIGA (NCT01191021)
- Testing
- Propofol Anesthesia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain on Injection of Propofol,Lidocaine, Alkalinized Lidocaine
Pain on Injection of Propofol: a Comparison of Lidocaine and Alkalinized Lidocaine
Aim: The aim of this study was to compare the efficacy of pretreatment 0.5 mg/kg lidocaine and 0.5 mg/kg alkalinized lidocaine for prevention of propofol induced pain.
- Trial name
- NCT01773044
- Testing
- alkalinized lidocaine, Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Inonu University
Induction of Anaesthesia
Explore the Clinical Application Value of Ciprofol in Painless Colonoscopy
This study used propofol as a positive control, and adopted a large-sample, multi-center, randomized, double-blind, positive parallel controlled trial design to explore the clinical application value of ciprofol in painless…
- Trial name
- NCT05294679
- Testing
- Propofol, Ciprofol
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Electroencephalography
EEG Analysis During Light Propofol Sedation
The hypothesis of this study is that propofol sedation does not affect the detectability of a movement intention in the EEG motor cortex signal.
- Trial name
- MOTANA (NCT03362775)
- Testing
- Propofol
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Digestive System Diseases, Disorientation
Opioid Effects on Cognitive Function Following Colonoscopy
This study aims to compare the effects of fentanyl and alfentanil on postprocedural cognitive function in elective endoscopy. 150 patients will be enrolled in the study.
- Trial name
- NCT02267681
- Testing
- Fentanyl, Alfentanil, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Perihan Ekmekçi
ERCP
Benzydamine Hydrochloride Gargle in Reducing Propofol for ERCP
It was a study aimed to determine the effectivity of benzydamine hydrochloride gargling in reducing propofol consumption in the Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure.
- Trial name
- ERCP (NCT04167592)
- Testing
- Benzydamine Hydrochloride 0.15% Oral Rinse, Water
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Propofol Pharmacokinetics
Propofol Pharmacokinetics in Children After Single Bolus Dose
The principle objective of this study is to evaluate pharmacokinetics of propofol after single iv bolus dose in 12 Indian children and to develop a simple pharmacokinetic model of propofol.
- Trial name
- NCT02303223
- Testing
- Propofol
- Where
- India
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sedation
Intravenous Infusion of Lidocaine in ERCP
Intravenous infusion of lidocaine significantly reduces propofol dose for ERCP and improve patients' recovery after ERCP.
- Trial name
- NCT03996577
- Testing
- Lidocaine
- Where
- 2 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shandong University
Nausea and Vomiting, Postoperative
Propofol Versus Dexmedetomidine on the Incidence of Postoperative Nausea and Vomiting
Post-operative nausea and vomiting are a leading cause of recovery room delays and low patient satisfaction. Complications such as suture line tension, wound hemorrhage and dehiscence, elevated intracranial pressure, pulmonary…
- Trial name
- NCT05875077
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dream, Day, Ketamine Adverse Reaction
The Impact of Preoperative Suggestion on Dreaming
Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.
- Conditions
- Dream, Day, Ketamine Adverse Reaction, Propofol Adverse Reaction
- Trial name
- NCT06609538
- Testing
- Control Group, Suggestion Group
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Colonoscopy
Effects of Intravenous Lidocaine During Sedation for Colonoscopy.
This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the…
- Trial name
- NCT02784860
- Testing
- Lidocaine, normal saline
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Liege
One-Lung Ventilation, Thoracic Surgery
The Effect of Anesthesia on Cerebral Oxygenation
One-lung ventilation (OLV) may cause negative changes in the oxygenation of cerebral tissue which results in postoperative cognitive dysfunction.
- Conditions
- One-Lung Ventilation, Thoracic Surgery, Postoperative Cognitive Complications
- Trial name
- NCT04760262
- Testing
- Sevoflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Controlled Hypotension for Nasal Surgeries
Comparison of Two Sedative Agents in Terms of Controlled Hypotension
Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention.
- Trial name
- NCT07460050
- Testing
- Propofol, Isoflurane
- Where
- Pakistan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Anesthesia, Psychomotor Status
Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy
This is a prospective cohort study that will analyze psychomotoric recovery using a commercially available driving simulator following sedation for endoscopic procedures in subjects undergoing elective outpatient endoscopic…
- Trial name
- NCT04350424
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Anesthesia
EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation
The investigators are performing this research study to find out if intravenous (IV) methylphenidate (commonly known as Ritalin) can help people recover faster from propofol sedation.
- Trial name
- NCT03610282
- Testing
- IV Methylphenidate, Propofol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ketamine, Sedation
Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case
Comparison of fentanyl-propofol and ketamine-propofol combination for sedation in brief gynecological cases Our study aimed to evaluate ketamine-propofol and fentanyl-propofol combinations in short-term gynecological cases in…
- Conditions
- Ketamine, Sedation, Gynecologic Disease
- Trial name
- NCT06412861
- Testing
- Ketamine, Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Etomidate Combined With Propofol, Hypertension
Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol for total intravenous anesthesia in elderly patients undergoing abdominal surgery.
- Trial name
- NCT07019246
- Testing
- EP mixture, Propofol
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital