Clinical trials: Propofol
Etomidate Combined With Propofol, Hypertension
Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol for total intravenous anesthesia in elderly patients undergoing abdominal surgery.
- Trial name
- NCT07019246
- Testing
- EP mixture, Propofol
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Measurement of Pupil Diameter
Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry
Null hypothesis (HO): There will be no difference in pupillometry readings when using any of the maintenance anesthetic techniques within subjects.
- Trial name
- NCT00695890
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Acute Cholecystitis
The Comparison of Hemodynamic Effects Between Remimazolam-remifentanil and Propofol-remifentanil in Patients Undergoing Laparoscopic Cholecystectomy
This study is conducted to determine whether the occurrence of hypotension is reduced by the combined use of remimazolam and remifentanil compared to the conventional combination use of propofol and remifentanil.
- Trial name
- NCT05164159
- Testing
- propofol group, remimazolam group
- Where
- South Korea
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Procedural Pain
Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain
Propofol is a commonly used intravenous anesthetic agent, but its administration is frequently associated with injection pain, causing patient discomfort and agitation.
- Trial name
- NCT07422558
- Testing
- Nalbuphine, Lidocaine
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Injection Site Coldness, Propofol Adverse Reaction
The Effect of Body Mass Index In Relation To Menstrual Cycle Phase on Propofol Injection Pain
There are suggestions from experimental pain studies that pain perception in patients with severe obesity differs compared with individuals with lower BMI values, with a tendency for patients with severe obesity to be hypoalgesic…
- Trial name
- NCT04078087
- Testing
- Non obese, Obese.
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Ketamine-dexmedetomidine Induction of Anesthesia
Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study
To compare the hemodynamic effects of Ketamine-Dexmedetomidine admixture (Ketodex) versus propofol-ketamine admixture (Ketofol) during induction of anesthesia in elderly
- Trial name
- NCT07002073
- Testing
- Intravenous Induction of Anesthesia
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Procedural Sedation
Ketofol Versus Fenofol as Procedural Sedation for Carpal Tunnel Release
There are different methods of anesthesia for CTR surgery. Procedural sedation will allow rapid recovery and fewer complications than regional or general anesthesia (GA).
- Trial name
- NCT04686448
- Testing
- propofol-ketamine, propofol-fentanyl
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Anesthesia
Pharmacokinetic/Pharmacodynamic Model of Propofol in Children
By measuring plasmatic concentration of propofol at different intervals during surgery of children aged 1 to 12 years old and measuring Bispectral Index (BIS) as a surrogate for cerebral activity, the investigators aim to create…
- Trial name
- NCT02544854
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Pain
Postoperative Analgesia in Children After Propofol Anesthesia
The investigators hypothesize that patients anesthetized with sevoflurane have more pain, postoperatively, than those anesthetized with propofol.
- Trial name
- propan (NCT01342835)
- Testing
- Propofol
- Where
- Serbia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Cholecystolithiasis
Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy
Laparoscopic Cholecystectomy applied to Artificial pneumoperitoneum and the extent of Surgical stimulation cause the wave of hemodynamics increase vigorously, which make it difficult to judge the depth of anesthesia according to…
- Trial name
- CLTCI (NCT02114437)
- Testing
- Closed-loop TCI, Opened-loop TCI
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Injection Site Irritation
Valsalva Manoeuvre and Intravenous Dexmedetomidine on Attenuating Pain During Propofol Injection in Upper GIT Endoscopy
No previous study has cited the use of the Valsalva manoeuvre for the reduction of pain on propofol injection in comparison with dexmedetomidine injection.
- Trial name
- Valsalva (NCT05225610)
- Testing
- Valsalva Manoeuvre, Dexmedetomidine Injection [Precedex], normal Saline
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tanta University
Anesthesia
Role of LIDOCAINE IN Pediatric Cochlear Implant Surgery
The stapedius reflex protects the ear from the loud noise. The measurement of the intraoperative electrically evoked stapedial reflex threshold (ESRT) during pediatric cochlear implants (CIs) is used to confirm that the implant…
- Trial name
- NCT04194294
- Testing
- Lidocaine, Na CL 0.9%
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wahba bakhet
Anesthesia, Acute Pain
Comparative Effects of Ciprofol and Propofol on Pain Intensity on the First Day After Surgery: a Retrospective, Propensity Score Matched, Cohort Study
Data intelligence platform was widely used to facilitate the process of clinical research. However, a platform that integrates natural language processing (NLP) and machine learning (ML) algorithms has not been reported in…
- Conditions
- Anesthesia, Acute Pain, Risk Reduction
- Trial name
- NCT06020469
- Where
- China
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Guangdong Second Provincial General Hospital
Colonoscopy
Effects of Intravenous Lidocaine During Sedation for Colonoscopy.
This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the…
- Trial name
- NCT02784860
- Testing
- Lidocaine, normal saline
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Liege
Anxiety Postoperative
Evaluation of the Effects Using the Combination of Sedative Agents on Dental Anxiety in Pediatric Patients
The aims of this study were firstly, to evaluate the changes in the anxiety level after deep sedation with various intravenous sedative agents using salivary cortisol level in pediatric dental patients and secondly, to compare…
- Trial name
- NCT04623970
- Testing
- Dental Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Postoperative Recovery
Ketamin Plus Propofol for Anesthesia Induction
ASA I-II 112 pediatric patients will recruit who underwent adenoidectomy-tonsillectomy surgery. Propofol 1 mg/kg + ketamin1 mg/kg (1/1 ratio) for group I; propofol 1,5 mg/kg + ketamin 0,75 mg/kg (2/1 ratio) for group II; propofol…
- Trial name
- NCT04761159
- Testing
- Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Gynecological Disorder
Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain
Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals.
- Trial name
- NCT04547608
- Testing
- The difference of the timing of rocuronium administration after propofol injection
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Pain
Minimal Effective Concentration of Lidocaine in Propofol Lidocaine Mixture for Relief of Pain on Propofol Injection
The research will be carried out in order to determine the optimal lidocaine concentration in propofol lidocaine mixture to prevent pain on propofol injection during induction of general anesthesia using a modified Dixon's…
- Trial name
- NCT05165303
- Testing
- lidocaine with propofol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Hypoxia, Anesthetics
Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
- Conditions
- Hypoxia, Anesthetics, Conscious Sedation, Hypercapnia
- Trial name
- NCT01873612
- Testing
- Hypoxic ventilatory response, Hypercapnic ventilatory response
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center