Clinical trials: Propofol Dosage
Hypothyroidism, Anesthesia, General
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Introduction: GABAergic synaptic transmigration in the anterior cingulate (ACC) cortex of hypothyroid rats has been demonstrated by electrophysiologic recordings.
- Conditions
- Hypothyroidism, Anesthesia, General, Propofol Dosage, Magnetic Resonance Imaging (MRI)
- Trial name
- BrainGABA (NCT06649318)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Anesthesia
Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application
Cystoscopy is a simple, effective and reliable method in current urological practice. Anesthesia may be required in cystoscopy for therapeutic purpose, however it may not be necessary for diagnostic cystoscopy.
- Trial name
- NCT03424356
- Testing
- Rocuronium Bromide, Saline Solution, Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Anesthesiology, Anesthesiology Management
Machine Learning-Based Model for Individualized Drug Dose Prediction for Propofol
The goal of this observational study is to develop an individualized prediction model for drug dosage during propofol-induced loss of consciousness in anticipation of advances in research in this area.
- Trial name
- NCT06703879
- Testing
- Anesthesia induction with propofol
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Thyroidectomy
The Effect of Preoperative Anxiety Level on the Induction Dose of Propofol and Minimum Alveolar Concentration (MAC) Hour of Sevoflurane During Thyroidectomy
This study is to evaluate the level of anxiety, and to check the correlation of induction dose and the amount of sevoflurane to keep anesthetic depth in in female patients undergoing thyroidectomy.
- Trial name
- NCT01149239
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Anesthesia, General
Automated Anesthesia During Bronchoscopy
The purpose of this study is to compare manual administration of propofol and remifentanil and dual closed-loop using bispectral index as the control variable during rigid bronchoscopy.
- Trial name
- NCT00571181
- Testing
- Closed-loop system, TCI (Infusion Toolbox)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Hopital Foch
General Anesthesia With Propofol, Closed-Loop
Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine
The propofol-remifentanil closed-loop TCI system based on EEG guidance has been clinically verified, which enables more precise anesthetic dosing.
- Trial name
- NCT06729892
- Testing
- Esketamine at low dose, new BIS baseline, an equivalent dose of saline
- Volunteers
- 120 people
- Sponsor
- bo xu
Anesthesia
Ketamine and Propofol for Upper Endoscopy
The purpose of this study is to examine the dose-response relationship of ketamine in combination with propofol.
- Trial name
- NCT02295553
- Testing
- Ketamine, Propofol
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- The Hospital for Sick Children
Patients Requiring Ambulatory Surgery Under General Anesthesia
Propofol for Supreme LMA Insertion With and Without Remifentanil
The aims of this study were to determine the clinically required concentration of propofol for LMA Supreme insertion, and to examine to what extent remifentanil reduces the dose of propofol and improves conditions for it's…
- Trial name
- SC50 (NCT01974648)
- Testing
- propofol, propofol and remifentanil
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Anesthesia, Ringer's Lactate
Ringer Lactate Preloading on Induction Dose Requirement of Propofol
To compare the effect (heart rate and mean arterial pressure) of Ringer Lactate preloading and without preloading on induction dose requirement of Propofol.
- Trial name
- NCT05777135
- Testing
- Ringer Lactate prior to surgery and Propofol
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Medical College Birgunj
Analgesia
The Influence of Genetic Polymorphism on Dose- Dependent Analgesic Response and Safety to Propofol in General Anesthesia
This study investigates the influence of genetic polymorphisms in key drug-metabolizing enzymes-CYP2B6, CYP2C9, and UGT1A9-on the individual response to propofol, a widely used intravenous anesthetic, in patients undergoing…
- Trial name
- NCT07543523
- Testing
- Propofol Group, Isoflurane Group
- Where
- Pakistan
- Volunteers
- 159 people
- Sponsor
- Superior University
Propofol Overdose, EEG
Dose-response Curves Between Propofol and Intraoperative Electroencephalographic Patterns
In the world, 230 million surgeries are performed per year and a significant part is performed in patients over 65 years of age.
- Trial name
- NCT04345926
- Testing
- Propofol, Electroencephalogram recording
- Where
- 2 sites in Chile
- Volunteers
- 15 people
- Sponsor
- University of Chile
Remifentanil, Analgesia
Optimal Dosage of Remifentanil for Vertebroplasty
Percutaneous vertebroplasty has become a mainstay in the management of osteoporotic and malignant vertebral fractures. Procedural analgesia and sedation (PAS) with propofol and remifentanil may provides optimal hypnotic and…
- Trial name
- NCT05876039
- Testing
- Initial remifentanil effect-site concentration
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Esketamine, Loop Electrosurgical Excision
Anesthesia for Loop Electrosurgical Excision Procedure (LEEP).
The goal of this prospective, randomized controlled study study is to investigate the efficacy and safety of propofol combined with different doses of esketamine (ESK) for anesthesia during loop electrosurgical excision procedure…
- Conditions
- Esketamine, Loop Electrosurgical Excision, Propofol
- Trial name
- ESK，LEEP (NCT06574945)
- Testing
- intravenous injection of propofol only, intravenous injection of propofol +esketamine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Qian Wu
Anesthesia
Determine the ED50 of Dexmedetomidine to Facilitate LMA Insertion During Anaesthesia Induction
Dexmedetomidine can be used as a co-induction agent to facilitate laryngeal mask airway (LMA) insertion with minimal effect on respiratory function.
- Trial name
- NCT02386462
- Testing
- Dexmedetomidine, Propofol
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Healthy Subjects
Pilot Study of Bioequivalence of Cudafol(R) and Diprivan(R) Administered as Single Intravenous Doses in Healthy Subjects
Evaluate pharmacokinetic/pharmacodynamic equivalence and safety and tolerability of single doses of Cudafol(R) and Diprivan(R) in healthy subjects.
- Trial name
- NCT02713802
- Testing
- Cudafol(R) (propofol, 1% [10 mg/mL]), Diprivan(R) (propofol, 1% [10 mg/mL])
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cuda Anesthetics, LLC
Intubation; Difficult
Intubation Time With Low Dose Rocuronium
The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation.
- Trial name
- NCT01464489
- Testing
- Atropine, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Gachon University Gil Medical Center
Cerebral Palsy
Optimal Dose of Propofol for Induction of Deep Sedation for Brain MRI Scanning in Children With Cerebral Palsy
The children with CP has been shown different drug responses from the normal population of children and it may related with a various oral medications such as baclofen, tizanidine, diazepam, dantrolene, or anticonvulsant drugs.
- Trial name
- NCT01244113
- Testing
- propofol
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Lactating Women
A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure
The purpose of this study is to assess the transfer of fospropofol and its active metabolite, propofol, to breast milk following administration of LUSEDRA® to lactating women undergoing a needed procedure.
- Trial name
- NCT01309984
- Testing
- Lusedra, Propofol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eisai Inc.
Patients Undergoing Elective Craniotomy
Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia
Efficacy of adding low dose ketamine or fentanyl to propofol-dexmedetomidine as total intravenous anesthesia for patients undergoing craniotomy in supra tentorial brain tumor
- Trial name
- TIVA (NCT06031883)
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University