Clinical trials: Propofol Pharmacodynamics
Target Controlled Infusion of Propofol
Validation Study of Covariates Model (VaSCoM) for Propofol
Anaesthesia for surgical procedures can be provided using a continuous infusion of intravenous drug. The most commonly used drug for this technique is propofol.
- Trial name
- VaSCoM (NCT01492712)
- Testing
- Propofol
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Golden Jubilee National Hospital
Healthy
Population Pharmacokinetics/Pharmacodynamics (PK/PD) of Microemulsion Propofol in Healthy Volunteers
AquafolTM (Daewon Pharmaceutical Co., Ltd., Seoul, Korea) is a microemulsion propofol that has been developed for eliminating lipid solvent-related adverse events of long chain triglyceride emulsion (LCT) propofol (Diprivan®…
- Trial name
- NCT00908726
- Testing
- propofol
- Where
- South Korea
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Morbid Obesity
Population PK/PD of Propofol in the Morbidly Obese Patient
Rationale: The extreme increase of obesity in the last years had led to this study. There is no consensus about how to anaesthetise morbidly obese patients.
- Trial name
- NCT00395681
- Testing
- Diprivan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Obesity
Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response
The aim of this study is to characterize the Pharmacokinetic/Pharmacodynamic relationship of a single bolus dose of propofol in obese patients and to extract a time to peak effect (t-peak) from the estimated model parameters.
- Trial name
- NCT01665079
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Morbid Obesity
A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects
This study will determine how morbid obesity affects the distribution and metabolism of the drug propofol. The investigators hypothesize that propofol will be distributed and metabolized differently in morbidly obese subjects as…
- Trial name
- NCT01591148
- Testing
- propofol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Pain
Pharmacodynamic Differences Between Branded and Unbranded Remifentanil Molecules
Unbranded drug molecules are produced after the patent of a given drug has expired. Unbranded molecules of Remifentanil have been marketed in Colombia, and several reports by anesthesiologist indicate that there are differences…
- Trial name
- NCT02048293
- Testing
- Remifentanyl, Ultiva®, Remifentanil Laboratorios Chalver de Colombia S.A., Fada Remifentanilo
- Where
- Colombia
- Volunteers
- 90 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Anesthesia
Genetic Differences in Propofol Pharmacodynamics in Children
Propofol is an extensively utilized intravenous sedative and general anesthetic. However, propofol has a narrow therapeutic index, and this means that there is only a small difference in the dose required to produce loss of…
- Trial name
- NCT04164264
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- University of British Columbia
General Anesthesia
Exploratory Study of Propofol and Fentanyl Pharmacodynamics
Exploration of the hypothesis that general anesthesia is not a singular threshold but is a continuum of central nervous system depression dependent on interpretation of nociceptive stimuli.
- Trial name
- NCT01550770
- Testing
- propofol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ethicon Endo-Surgery
Deep Sedation
Prospective Validation of the Eleveld Model of Propofol for Procedural Sedation in Adults.
The goal of this prospective observational study is to identify effect site concentrations (CET) of propofol using the Eleveld model for different levels of procedural sedation.
- Trial name
- NCT06325033
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Anesthesia for Elective Surgery Patients, Anesthesia Brain Monitor
Reevaluation Prediction of the Effect Site Propofol Eleveld Model Using Slow and Fast Induction
Patients ASA1-2, 18 to 70 years old, scheduled for elective surgery with personal conset to participate, will be randomised into two groups using different induction mode.
- Conditions
- Anesthesia for Elective Surgery Patients, Anesthesia Brain Monitor, Pharmacodynamics
- Trial name
- fast or slow E (NCT07237477)
- Testing
- Evaluation of the prediction of from the propofol PKPD model including in TCI pumps using fast (Effect site mode TCI) or slow (plasma TCI mode) induction
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- Pablo O. Sepulveda
Surgery Related to Lower Extremity Under Spinal Anesthesia
Population Pharmacodynamic Modeling of the Sedative and Side Effects of Propofol
Sedation during spinal anesthesia is very useful for patients' comfort. However, intermittent bolus of sedative frequently results in inappropriate sedation which comes with various side effects such as patients' discomfort and…
- Trial name
- NCT02173340
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Healthy
the Effect Site Equilibration Time of Propofol is Age Dependant
This study obtains an effect site model for White (Modified Marsh) pharmacokinetic propofol model. The plasma effect-site rate constant (ke0) obtained is affected by age.
- Trial name
- ke0agedep (NCT01586013)
- Testing
- evaluation of propofol effect using BIS
- Where
- Chile
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Anesthesia
Remifentanil and Midazolam on Propofol for Loss of Consciousness
Propofol in combination with remifentanil or midazolam can result in synergistic or additive effect. The patients who are scheduled to undergo general anesthesia are enrolled in this study.
- Trial name
- NCT02536690
- Testing
- Propofol, Remifentanil, Midazolam
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Severance Hospital
Aged
Development of a Pharmacodynamic Model for Propofol in Older Adults
The goal of this pharmacodynamic study is to develop a model for Propofol administration for older adults (>65 years). The main objective is to create a model based on a new pharmacodynamic parameter, derived from frontal…
- Trial name
- DROPLET (NCT05790720)
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Pharmacodynamic Interaction
Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia
The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).
- Trial name
- PIPDIA (NCT02777619)
- Testing
- 0.0ng/ml Dexmedetomidine, 0.4ng/ml Dexmedetomidine, 0.6ng/ml Dexmedetomidine
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Gender
Gender and PK-PD of Propofol and Cisatracurium
In recent years it has become clear that gender differences exist both in the pharmacokinetics and the pharmacodynamics of drugs related to the practice of anesthesia.
- Trial name
- BIS5 (NCT02588118)
- Testing
- propofol, Cisatracurium
- Where
- 2 sites in Austria, China
- Volunteers
- 120 people
- Sponsor
- Medical University of Graz
Anesthesia
Pharmacokinetic/Pharmacodynamic Model of Propofol in Children
By measuring plasmatic concentration of propofol at different intervals during surgery of children aged 1 to 12 years old and measuring Bispectral Index (BIS) as a surrogate for cerebral activity, the investigators aim to create…
- Trial name
- NCT02544854
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Sedation and Analgesia, Cholangiopancreatography, Endoscopic Retrograde
EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives
Recording and analyzing electroencephalogram (EEG) and continuous pain monitor data under anesthesia in order to investigating the pharmacodynamic effects of opioids and sedatives.
- Conditions
- Sedation and Analgesia, Cholangiopancreatography, Endoscopic Retrograde, Anesthesia, General
- Trial name
- SED-ERCP (NCT07211828)
- Testing
- high dose of alfentanil, low dose of alfentanil with propofol
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chi Kwan Fung
Anesthesia
Remifentanil and Midazolam on Propofol for Loss of Consciousness in Elderly Patients
Propofol is a well-known induction agent which can provide sound and quick hypnosis with anti-emetic effects. However, dose dependent hypotension or bradycardia have reported while using this agent.
- Trial name
- NCT02818387
- Testing
- Propofol, Remifentanil, Midazolam
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Gangnam Severance Hospital
Obesity, Elective Surgery
Development of PK/PD Model for Individualized Propofol Dosing
The U.S. National Health and Nutrition Examination Survey of 1994 indicated that 59% of American men and 49% of women have body mass indexes (BMIs) over 25.
- Trial name
- NCT00948597
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati