Clinical trials: Propofol Pharmacodynamics
Propofol Overdose of Undetermined Intent
Performance Evaluation of Four Pharmacokinetic-Pharmacodynamic(PKPD) Models of Propofol in Elderly Patients
Despite the wide use of propofol target-controlled infusion (TCI) in elderly patients, pharmacokinetic (PK) and pharmacodynamic (PD) models performance has not been prospectively assessed in this population.
- Trial name
- TCIGeriatric (NCT01435785)
- Where
- 2 sites in Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Hypnotic Effect
Monitoring of Hypnosis State During General Anesthesia With Propofol by Patient State Index From SEDLine®
The purpose of this study is the evaluation of possible relationships and correlation between PSI values obtained from the SEDLine® monitor and the infusion rate of propofol during general anesthesia.
- Trial name
- NCT02706665
- Testing
- SEDline monitor
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Universitario de Canarias
Intravenous Anesthetic Agent Overdose
Propofol Pharmacokinetics and Pharmacodynamics Modelling
The main purpose of this research is to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia, using BIS as a pharmacodynamic endpoint.
- Trial name
- NCT02713698
- Testing
- Propofol
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar do Porto
Propofol, Child
Time to Peak Effect of Propofol in Children
In order to determine the speed of onset of the anaesthetic propofol in children, investigators will compare the two age groups 1-6 years vs 8-13 years.
- Trial name
- TPEPC (NCT03426462)
- Testing
- Propofol
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Volunteers
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of KL0011034 Injection Administered by Continuous Infusion in Healthy Adult Subjects
This study is a randomized, double-blind, propofol position-controlled trial, evaluating the safety, tolerability, and pharmacodynamic of continuous infusion of KL0011034 injection compared with propofol injectable emulsion for…
- Trial name
- NCT07828470
- Testing
- KL0011034 injection, propofol injectable emulsion
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hunan Kelun Pharmaceutical Co., Ltd.
Anesthesia Intubation Complication, Premature Birth of Newborn
Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation
Newborns admitted to an intensive care unit often require artificial ventilation. For that purpose an endotracheal tube needs to be placed into the trachea, a procedure named endotracheal intubation.
- Conditions
- Anesthesia Intubation Complication, Premature Birth of Newborn, Other Preterm Infants, Propofol Overdose
- Trial name
- NEOPROP2 (NCT02040909)
- Testing
- Propofol
- Where
- 3 sites in Netherlands
- Volunteers
- 91 people
- Sponsor
- Erasmus Medical Center
Coronary Artery Disease, Cardiopulmonary Bypass
Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Coronary Artery Bypass Graft
- Trial name
- NCT00622791
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Anesthesia, Burned
Development of pk/pd Model of Propofol in Patients With Severe Burns
Burn injuries are a prevalent problem. Actually, in Chile the Ministry of Health has recorded 6435 hospital burns and has reported 569 deaths from this cause.
- Conditions
- Anesthesia, Burned, Operative Wound
- Trial name
- HUAPQ (NCT03704285)
- Testing
- Propofol, BIS
- Where
- Chile
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Victor Contreras, MSN
Pharmacodynamics, Obesity
Propofol in Obese Children
Obesity in children,as in adults,has rapidly become a public health concern. Studies in adults have shown that obesity, now considered to be a disease state, is a modifier of the effect of drugs on the body as well as how the…
- Trial name
- NCT01242241
- Testing
- Propofol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Anesthesia
A PK/PD Study of Fospropofol Disodium Compared With Propofol Injectable Emulsion
This study is designed to characterize the pharmacokinetic and pharmacodynamic effect of fospropofol disodium in comparison to propofol.
- Trial name
- NCT01260142
- Testing
- Fospropofol disodium, propofol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Obesity
Validation of a Pharmacokinetic Pharmacodynamic Model to Administer Propofol in Obese Patients
The purpose of this study is to validate an integrated pharmacokinetic-pharmacodynamic model to administer propofol in obese patients.
- Trial name
- NCT01596387
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Monitored Anesthesia Care
A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion
The purpose of this study is to explore the pharmacokinetics (PK) and pharmacodynamics (PD) of LUSEDRA® administered as a continuous infusion or bolus compared with continuous infusion of propofol injectable emulsion.
- Trial name
- NCT01308541
- Testing
- arm 1, LUSEDRA, Propofol (arm 3)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
General Anesthesia, Propofol Pharmacodynamics
Neuronal Inertia in Propofol Anesthesia
Loss and recovery of consciousness during propofol anesthesia seem to be mediated by different mechanisms beyond the actual effect-site concentration of anesthetic drug.
- Conditions
- General Anesthesia, Propofol Pharmacodynamics, Propofol Target Controlled Infusion, Loss of Consciousness and Recovery of Consciousness
- Trial name
- INERTIA (NCT01962285)
- Testing
- propofol targel controlled infusion
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo