Clinical trials: Prospective Study
Pain, Injection Site Reaction
Safety of Pediatric COVID-19 Vaccination
This is a prospective, observational study. During the study, children and adolescents (ages ≥ 5 to < 16) will be followed post administration of mRNA COVID-19 vaccines.
- Conditions
- Pain, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05157191
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Duke University
Skin Aging
A Clinical Study to Evaluate the Efficacy and Safety of Monopolar Radiofrequency Combined With SkinCeuticals A.G.E and Skinceuticals CE FERULIC for Improving Facial Skin Elasticity, Tightening and Fading Fine Lines
A Prospective, Single-center, Single-blind, Randomized split-face, controlled trial will be conducted. The goal of this clinical trial is to evaluate the efficacy and safety of monopolar radiofrequency combined with SkinCeuticals…
- Trial name
- NCT06228833
- Testing
- monopolar radiofrequency, SkinCeuticals A.G.E and Skinceuticals CE FERULIC, Standard Cream
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yes Skin Medical Group
Anesthesia, Block
Evaluating the Effectiveness of Bilateral ESPB in Addition to Standard Analgesia at Reducing Opioid Consumption
Study the benefits of a Erector Spinae nerve block for pain control and decrease narcotics usage after mammoplasty in an ambulatory setting
- Trial name
- NCT03954249
- Testing
- Erecto Spinae nerve block, Multimodal Analgesia
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Diabetes Mellitus Without Complication
Prevent Diabetic Kidney Disease Among Egyptians
Study of the possibility to prevent the development of Diabetic kidney disease in type 2 diabetic patients
- Trial name
- NCT06071208
- Testing
- Gliflozin
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Postpartum Anxiety, Postpartum Depression
Postpartum Screening for Anxiety and Comorbid Conditions
The goal of this project is to facilitate the design of individualized postpartum anxiety (PPA) screening strategies in British Columbia (BC), Canada.
- Conditions
- Postpartum Anxiety, Postpartum Depression, Postpartum Disorder, Postoperative Pain
- Trial name
- PPA (NCT06242717)
- Where
- Canada
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
COVID-19
Multisite Observational Maternal and Infant Study for COVID-19
This is an observational, non-interventional, prospective cohort study designed to collect clinical information and specimens to evaluate the immune responses from pregnant individuals and postpartum individuals and their infants…
- Trial name
- MOMI-Vax (NCT05031468)
- Testing
- Licensed or EUA SARS-CoV-2 vaccine
- Where
- 10 sites in United States
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Emory University
High-Normal Blood Pressure, Mild Essential Hypertension
Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension
Aspirin (ASA) has been shown to provide marked benefits in the prevention of cardiovascular events, although the potential direct effects of ASA on cardiovascular function remain uncertain.
- Trial name
- NCT00449618
- Testing
- Aspirin 100 mg, Ambulatory blood pressure monitoring, Chronotherapy, timing of medication
- Where
- 5 sites in Spain
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Healthy
Immune Health Biomarkers and Fecal Microbiota in Filipino Breastfed Infants
This will be a prospective observational study aiming to investigate immune health biomarkers and fecal microbiota in 48-60 Filipino breastfed infants from birth to 12 months of age.
- Trial name
- NCT06708559
- Testing
- Breast-fed infants
- Where
- Philippines
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Breast Cancer
The Efficacy and Safety of Abraxane Combined With Epirubicin as Neoadjuvant Chemotherapy in Breast Cancer
Some studies have demonstrated the efficacy of Abraxane in treating breast cancer in both adjuvant and metastatic settings. Few data is available on Abraxane in neoadjuvant treatment for breast cancer.
- Trial name
- NCT03647280
- Testing
- Abraxane, Epirubicin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Healthy
Study to Verify the Feasibility of Collecting a Broad Variety of Individual Health Data
The purpose of the OBSERVE PILOT is to verify the feasibility of collecting individual health data which is obtained through blood samples, continuous monitoring devices, medical imaging, a questionnaire, and a blood pressure…
- Trial name
- NCT03135678
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hilbert Paradox NV
Healthy Volunteers, Pharmacokinetics/Dynamics Study
A Short Term Pharmacokinetic, Pharmacodynamic and Tolerability Study to Compare AOP200704 vs. Esmolol
Pharmacokinetics, pharmacodynamics and tolerability of AOP200704 infusion is compared to that of Esmolol by measurement of plasma concentrations of AOP200704, esmolol and their metabolites, by assessing the effect of both drugs…
- Trial name
- NCT01313143
- Testing
- AOP200704, Esmolol hydrochloride, infusion
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AOP Orphan Pharmaceuticals AG
Hematologic Diseases
Clinical Study of Combined Platelet Transfusion
Platelet transfusion is an irreplaceable and important treatment method for clinical prevention and treatment of thrombocytopenia or platelet dysfunction.
- Trial name
- NCT06613425
- Testing
- Combined platelets
- Where
- China
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- The General Hospital of Western Theater Command
Lactation, Bone Diseases, Endocrine
African-American Bone Metabolism and Lactation Study
The primary aim of this study is to obtain measures of amino-terminal telopeptides of procollagen 1 (P1NP), a marker of bone formation, in lactating and non-lactating post-partum African-American women both at 6-8 and at 12-14…
- Trial name
- NCT00785824
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
POSTOPERATIVE ANALGESIA FOR TKA PARECOXIB/CFB
Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty
Combination of continuous femoral block with parEcoxib vs placebo. Investigation of morphine consumption, opioid sparing effects, VAS pain scores, haemodynamics, Anxierty scores, transfusion requirements , Range of motion and…
- Trial name
- NCT02185924
- Testing
- Parecoxib, CONTINUOUS FEMORAL BLOCK WITH ROPIVACAINE 0,2%, N/S 0.9%
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Asklepieion Voulas General Hospital
Endothelial Dysfunction, Periodontal Diseases
Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study
An association between periodontitis and endothelial dysfunction has been reported, suggesting that periodontitis presents an inflammatory burden to the cardiovascular system, that might lead to AVD.
- Trial name
- NCT05691426
- Testing
- Assessment of pulse wave amplitude (PWA), Salivary Nitric Oxide
- Where
- United Arab Emirates
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Photo-damaging
A Clinical Study to Evaluate the Efficacy and Satisfaction of the Skinceuticals Skin Care Product (CE FERULIC) for Skin Repair Post Fraxel Laser Treatment
A Prospective, Single-center, Single-blind, Randomized split-face, controlled trial will be conducted. The goal of this clinical trial is to evaluate the efficacy and satisfaction of the Skinceuticals skin care product (CE) for…
- Trial name
- NCT06026085
- Testing
- Skinceuticals skin care product(CE), fraxel laser therapy, 0.9% normal saline
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- DeYi Aesthetic Medical Clinic
Surgical Site Infection
Environmental Risk Factors of Mesh Infection After Abdominal Wall Hernia Repair
Mesh infection is the main complication in abdominal hernia repair. In case of infection, a conservative management of mesh is not always possible.
- Trial name
- NCT04174976
- Testing
- wall hernia repair
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Low Back Pain, Leg Pain
Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis
The purpose of this multi-center, randomized, clinical study is to establish the safety and effectiveness of the TOPS™ System, used following decompression, in the treatment of lower back and leg pain with, or without spinal…
- Conditions
- Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT00405691
- Testing
- "TOPS System" - Total Posterior Arthroplasty Implant
- Where
- 16 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Impliant, Ltd.
Healthy
Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ZYIL1 Following Oral Administration in Healthy Volunteers
ZYIL1 is a novel oral selective NLRP3 inflammasome inhibitor which prevents NLRP3-induced ASC oligomerization, thus inhibiting NLRP3 inflammasome pathway.
- Trial name
- NCT04731324
- Testing
- ZYIL1 capsule
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Sugammadex
Comparative Efficacy and Safety of Sugammadex and Neostigmine
Along with unconsciousness and analgesia, use a muscle relaxant (Neuromuscular blocking agent NMBA) is now part of the classic triad of anesthesia.
- Trial name
- NCT04997759
- Testing
- Neostigmine and Sugammadex
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital