Clinical trials: Prostaglandin E2
Periodontitis, Type 2 Diabetes
Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment
Diabetes and periodontal disease are the most common chronic multifactorial and inflammatory diseases in humans, and there is a bidirectional relationship between type 2 diabetes and periodontitis.
- Trial name
- NCT05454059
- Testing
- Non-surgical periodontal treatment, ELISA Test, Periodontal Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Ocular Inflammation
PGE2 Levels in Patient Treated With NSAIDs
The aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (NSAIDs) and prostaglandinE2 (PGE2) in eyes scheduled for vitrectomy. All patients received the study drugs for 3 days before surgery.
- Trial name
- NCT03597867
- Testing
- Dicloftil, Nevanac, Indom
- Where
- Italy
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Induced Labor, Cervical Ripening
Low-dose Vaginal Misoprostol Versus Vaginal Dinoprostone Insert for Induction of Labor
Purpose: To compare the efficacy and safety of low-dose protocol of vaginal misoprostol and vaginal dinoprostone insert for induction of labor in women with post-term pregnancies.
- Conditions
- Induced Labor, Cervical Ripening, Obstetric Labor, Pregnancy
- Trial name
- MADUTER (NCT03744364)
- Testing
- Misoprostol 25 mcg, Dinoprostone 10mg
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Labor, Induced
A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction
A randomized controlled trial comparing labor induction with vaginal PGE2 tablets and foley catheter for cervical ripening.
- Trial name
- NCT02486679
- Testing
- Prostin (PGE2) tablets, Foley catheter
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Preterm Premature Rupture of Fetal Membranes, Induction of Labor Affected Fetus / Newborn
A Randomized Trial of Induction Methods in Premature Rupture of Membranes
This study evaluates the addition of transcervical Foley catheter balloon and vaginal prostaglandin E2 induction in premature rupture of membranes.
- Trial name
- NCT03744078
- Testing
- Foley balloon catheter
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Medical Induction of Labor Affecting Fetus
Titrated Oral Misoprostol Compared to Vaginal Dinoprostone for Induction of Labor
To test the safety and efficacy of titrated oral misoprostol compared to vaginal dinoprostone for labor induction.
- Trial name
- NCT02036437
- Testing
- Misotac® Sigma Pharmaceutical Industries, Dinoprostone 3 mg
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Missed Abortion, Periodontitis
Periodontal Pathogens and Inflammatory Biomarkers in Missed Abortion
This observational case-control study will investigate whether periodontal infection and inflammation are associated with missed abortion in pregnancies without detected major fetal chromosomal abnormalities.
- Trial name
- NCT07864220
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Healthy, Third Molar Extraction Surgery
Evaluation of the Effect of Antibiotic Prophylaxis (2g Amoxicillin One Hour Before Surgery) on an Inflammatory Factor (PGE2) in Salivary Samples After Third Molars Surgery
This clinical trial aims to evaluate the impact of antibiotics on inflammation and pain in patients who have undergone mandibular third molar surgery. The primary research questions are: 1.
- Conditions
- Healthy, Third Molar Extraction Surgery, Antibiotic Prophylaxis, Amoxicillin
- Trial name
- NCT06613776
- Testing
- Amoxicillin
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Unfavorable Cervix, Cervical Ripening
Combined Foley Catheter Balloon and PGE2 Vaginal Ovule for Induction of Labor at Term: A Randomized Study
This study evaluates the addition of transcervical Foley catheter balloon and vaginal prostaglandin E2 in induction of labor at term.
- Trial name
- NCT02861079
- Testing
- Foley catheter, PGE2
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Apical Periodontitis, Inflammatory Markers
The Efficacy of Two Different Irrigation Methods on PGE2, NO and IL-6 Levels
Today, debates about the effectiveness of Passive Ultrasonic Irrigation (PUI) and Sonically Activated Irrigation (SAI) techniques used to increase the success of endodontic treatment in chronic apical periodontitis (AP) are still…
- Trial name
- NCT06629545
- Testing
- irrigation activation with PUI, irrigation with sonic activation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Headache, Migraine
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model
The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.
- Trial name
- NCT00957983
- Testing
- BGC20-1531
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Induction of Labor Affected Fetus / Newborn, Prostaglandins Causing Adverse Effects in Therapeutic Use
Induction of Labor in Term Pregnancies With Unfavourable Cervix
This is a prospective randomized trial comparing two prostaglandin E2 (dinoprostone) agents used for labor induction in pregnant women with term pregnancies and unfavorable cervix.
- Trial name
- RAND (NCT04280874)
- Testing
- Dinoprostone 0.5 MG, Dinoprostone 2 MG/2.5 ML Vaginal Gel/Jelly
- Where
- Croatia
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Merkur
Cataract
Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects
The purpose of this study is to compare the ability of two different topical NSAIDs (non-steroidal anti-inflammatory medications used for pain relief) to reach the back of the eye and to stop inflammation.
- Trial name
- NCT00469690
- Testing
- Acular, Xibrom
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Missed Abortion, Medical; Abortion, Fetus
Gemeprost Versus Dinoprostone in First Trimester Miscarriages
Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.
- Conditions
- Missed Abortion, Medical; Abortion, Fetus, Incomplete Abortion
- Trial name
- NCT05342467
- Testing
- Gemeprost 1 Mg Vaginal Pessary, Dinoprostone 3 mg
- Where
- 2 sites in Malaysia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Cervical Ripening
Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy
Comparison of intravaginal misoprostol and dinoprostol for the purpose of cervical ripening before diagnostic hysteroscopy in the women at the reproductive age:RANDOMİSED,CONTROLLED PROSPECTİVE TRİAL Objective.
- Trial name
- NCT01620814
- Testing
- Dinoprostone, misoprostol, control
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
GYN Disorders
Cervical Preparation in Hysteroscopy
The hysteroscopy was performed in the proliferativephase of the menstrual cycle. The patients were given generalintravenous anesthesia (propofol/fentanyl) after the vulvar and the vaginal area had been disinfected with a 7.5%…
- Trial name
- NCT03675802
- Testing
- misoprostol, dinoprostone
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Contraception
Comparative Efficacy of Lidocaine Spray Versus Vaginal Dinoprostone in IUD Insertion
the aim of this study is to compare the safety and Efficacy of Lidocaine Spray Versus Vaginal dinoprostone in relieving pain during levonorgestrel IUD Insertion in nulliparous women
- Trial name
- NCT04339361
- Testing
- lidocaine spray, vaginal dinoprostone
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myoma;Uterus
Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy
Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy
- Trial name
- NCT05761418
- Testing
- Dinoprostone, Misoprostol
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Early Amniotomy, Unfavorable Cervix
Early Amniotomy After Vaginal Prostaglandin E2 for Induction of Labor at Term: a Randomized Clinical Trial
This study evaluates the effectiveness and safety of early amniotomy after vaginal prostaglandin E2 for induction of labor at term.
- Trial name
- PGE2 (NCT02856724)
- Testing
- PGE2
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Labor Induction
Foley Catheter Versus Cervidil for Induction of Labor at Term
OBJECTIVE: To assess the efficacy of transcervical Foley catheter compared to controlled release prostaglandin (Cervidil™) for cervical ripening in term and near term women presenting for labor induction.
- Trial name
- NCT01402050
- Testing
- CERVIDIL (Dinoprostone), FOLEY BALLOON
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Pediatrix